Idebenone Acts against Growth of
            <i>Helicobacter pylori</i>
            by Inhibiting Its Respiration

Inatsu, Sakiko; Ohsaki, Ayumi; Nagata, Kumiko

doi:10.1128/aac.01118-05

Cited by 15 publications

(27 citation statements)

References 20 publications

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“…Previously, we reported [12] that furanonaphthoquinone and other quinones specifically inhibited the growth of H. pylori at low concentrations (1.6-3.2 lg ⁄ mL). pylori appears to be sensitive to quinone analogs.…”

Section: Discussionmentioning

confidence: 98%

“…Cockeysville, MD, USA) containing 5% horse serum (Donor Horse Serum manufactured by Thermo Trace Ltd., Melbourne, Australia) under a microaerobic atmosphere, at 37°C [12,25]. Clinical isolates of H. pylori were obtained from gastric biopsies of H. pylori-infected patients who were being treated at the Hyogo College of Medicine Hospital.…”

Section: Materials and Bacterial Strainsmentioning

confidence: 99%

“…The MICs of DHNA and clarithromycin related to H. pylori were determined as previously described [12,25,26]. Briefly, the inhibitors were dissolved in 100% dimethyl sulphoxide (DMSO) and diluted with 10 mmol ⁄ L HEPES buffer, pH 7.2 containing 0.9% NaCl, and then were transferred into 24-well tissue culture plates (Becton Dickinson Labware, Franklin Lakes, NJ, USA).…”

Section: Determination Of Mic Of Dhna and Clarithromycinmentioning

confidence: 99%

“…Respiration of whole cells (1-2 · 10 8 cells ⁄ mL) was monitored polarographically by using a Clark-type oxygen electrode (YSI Inc., Yellow Springs, OH, USA) in a semiclosed cell containing 10 mmol ⁄ L HEPES buffer and 0.9% NaCl, at 37°C [12,20]. Respiration of whole cells (1-2 · 10 8 cells ⁄ mL) was monitored polarographically by using a Clark-type oxygen electrode (YSI Inc., Yellow Springs, OH, USA) in a semiclosed cell containing 10 mmol ⁄ L HEPES buffer and 0.9% NaCl, at 37°C [12,20].…”

Section: Measurement Of Whole Cell H Pylori Respiration In the Presementioning

confidence: 99%

“…The ATP level in H. pylori cells was determined by using a luciferin-luciferase-based bioluminescence assay kit, Lucifier LU plus (Kikkoman Corporation, Chiba, Japan), and fluorescence activity was measured by using a Luminometer BLR-201 (ALOKA, Tokyo) as described previously [12,25].…”

Section: Measurement Of Cellular Atp Levelmentioning

confidence: 99%

See 4 more Smart Citations

The Bifidogenic Growth Stimulator Inhibits the Growth and Respiration of Helicobacter pylori

Nagata

Inatsu

Tanaka³

et al. 2010

Helicobacter

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show abstract

Section: Discussionmentioning

confidence: 98%

Section: Materials and Bacterial Strainsmentioning

confidence: 99%

Section: Determination Of Mic Of Dhna and Clarithromycinmentioning

confidence: 99%

Section: Measurement Of Whole Cell H Pylori Respiration In the Presementioning

confidence: 99%

Section: Measurement Of Cellular Atp Levelmentioning

confidence: 99%

See 3 more Smart Citations

The Bifidogenic Growth Stimulator Inhibits the Growth and Respiration of Helicobacter pylori

Nagata

Inatsu

Tanaka³

et al. 2010

Helicobacter

Self Cite

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Recent Advances in Inhibitors of Bacterial Fatty Acid Synthesis Type II (FASII) System Enzymes as Potential Antibacterial Agents

Wang

2013

ChemMedChem

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Bacterial infections are a constant and serious threat to human health. With the increase of multidrug resistance of clinically pathogenic bacteria, common antibiotic therapies have been less effective. Fatty acid synthesis type II (FASII) system enzymes are essential for bacterial membrane lipid biosynthesis and represent increasingly promising targets for the discovery of antibacterial agents with new mechanisms of action. This review highlights recent advances in inhibitors of bacterial FASII as potential antibacterial agents, paying special attention to the activities, mechanisms, and structure-activity relationships of those inhibitors that mainly target β-ketoacyl-ACP synthase, β-ketoacyl-ACP reductase, β-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase. Although inhibitors with low nanomolar and selective activity against various bacterial FASII have entered clinical trials, further research is needed to expand upon both available and yet unknown scaffolds to identify new FASII inhibitors that may have antibacterial potential, particularly against resistant bacterial strains.

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Anti-acne activities of pulsaquinone, hydropulsaquinone, and structurally related 1, 4-quinone derivatives

2009

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Quinone type compound, pulsaquinone 1, isolated from the aqueous ethanol extract of the roots of Pulsatilla koreana exhibited antimicrobial activities against an anaerobic non-spore-forming gram-positive bacillus, Propionibacterium acnes, which is related with the pathogenesis of the inflamed lesions in a common skin disease, acne vulgaris. Compound 1 was unstable on standing and thus converted to more stable compound 2, namely hydropulsaquinone by hydrogenation, whose activity was comparable to mother compound 1 (MIC for 1 and 2 against P. acnes: 2.0 and 4.0 microg/mL, respectively). Other structurally-related quinone derivatives (3-13) were also tested for structure-activity relationship against anaerobic and aerobic bacteria, and fungi. The antimicrobial activity was fairly good when the quinone moiety was fused with a nonpolar 6- or 7-membered ring on the right side whether or not conjugated (1,4-naphtoquinone derivatives 3-5), while simple quinone compounds 6-9 showed poor activity. It seems that the methoxy groups at the left side of the quinone function deliver no considerable antimicrobial effect.

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Idebenone Acts against Growth of Helicobacter pylori by Inhibiting Its Respiration

Cited by 15 publications

References 20 publications

The Bifidogenic Growth Stimulator Inhibits the Growth and Respiration of Helicobacter pylori

The Bifidogenic Growth Stimulator Inhibits the Growth and Respiration of Helicobacter pylori

Recent Advances in Inhibitors of Bacterial Fatty Acid Synthesis Type II (FASII) System Enzymes as Potential Antibacterial Agents

Anti-acne activities of pulsaquinone, hydropulsaquinone, and structurally related 1, 4-quinone derivatives

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