Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized

Saiki-Macedo, Stephanie; Valverde-Ezeta, Jorge; Cornejo-Tapia, Angela; Castillo, María E.; Petrozzi-Helasvuo, Verónica; Aguilar-Luis, Miguel Ángel; Valle, Luís J. del; Cieza-Mora, Erico; Bada, Carlos; Águila, Olguita del; Silva-Caso, Wilmer; Martins-Luna, Johanna; Vasquez-Achaya, Fernando; Valle-Mendoza, Juana del

doi:10.1186/s12879-019-3671-6

Cited by 18 publications

(15 citation statements)

References 40 publications

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“…However, in clinical practice, we found that other pathogens can also cause pertussis-like cough as part of pertussis-like syndrome. Stephanie Saiki-Macedo found that in Peru, there was a high prevalence of ADV, B. pertussis, MP and IV-B infection in patients with a probable diagnosis of pertussis [10]. In our study, detailed etiological examination was performed in 281 children who had typical pertussis-like syndrome.…”

Section: Discussionmentioning

confidence: 82%

Pathogen analysis of pertussis-like syndrome in children

Wang

Zhang

et al. 2020

BMC Infect Dis

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Background: The aim of the study was to identify the pathogens, in addition to bordetella pertussis (B. pertussis), which cause pertussis-like syndrome in children and to compare clinical presentation between those with B. pertussis and pertussis-like syndrome. Methods: A cross-sectional analysis was conducted from March 2016 to September 2018. In total, 281 children with suspected pertussis infections were enrolled in this study. Multi-pathogen detection was performed. Results: In total, 281 children were enrolled including 139 males and 142 females. Among them, 149 (53.0%) were B. pertussis positive, and 72 (15.6%) children tested positive for other pathogens. Mycoplasma pneumoniae (MP, 27 cases) was the most common causative pathogen in pertussis-like syndrome, followed by human rhinovirus (HRV, 23 cases), Streptococcus pneumoniae (SP, 13 cases), Haemophilus influenzae (HI, 12 cases) and parainfluenza virus 3 (Pinf-3, 9 cases). Children in the B. pertussis group had a higher rate of vaccination and longer hospital stay (P < 0.05). B. pertussis was more likely to be detected in winter than other pathogens, but this difference was not significant (P = 0.074). The number of white blood cells, neutrophils and blood platelets was significantly higher in children in the B. pertussis than in the pertussis-like group (P < 0.05). In addition, the percentage of CD3-CD19+ cells was significantly higher in the B. pertussis group (P = 0.018). Conclusion: About half of the children with pertussis-like syndrome were B. pertussis positive. MP was the second most common causative pathogen followed by HRV, SP, HI and Pinf-3. Children infected with B. pertussis had longer hospital stay and higher numbers of white blood cells, neutrophil and blood platelets compared with other pathogens.

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Section: Discussionmentioning

confidence: 82%

Pathogen analysis of pertussis-like syndrome in children

Wang

Zhang

et al. 2020

BMC Infect Dis

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“…The differentiation of pertussis and respiratory infections with pertussis-like coughing is possible only by determining causative microorganisms. B. parapertussis, Mycoplasma pneumoniae, Chlamydia pneumoniae, RSV, influenza virus, parainfluenza virus, adenovirus, metapneumovirus, rhinovirus and bokavirus are other microorganisms which should be considered in the differential diagnosis of pertussis [4,[20][21][22][23]. In our study, influenza virus, RSV, rhinovirus, parainfluenza virus, adenovirus, bocavirus and parainfluenza were causative agents in patients in Group 3.…”

Section: Discussionmentioning

confidence: 65%

“…Although it is vaccine preventable disease, it is endemic among children all over the world almost all the time and leads to outbreaks from time to time [2][3]. Other than B. pertussis there are respiratory tract infections which cause pertussis like coughing [4]. Clinical picture is difficult to differentiate between these entities.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the clinical and laboratory characteristics of pertussis or viral lower respiratory tract infections

Selbuz

Çıftçı

Özdemir

et al. 2019

J Infect Dev Ctries

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Introduction: Whooping cough-like respiratory tract infections (WCLRTI) caused by factors other than the Bordetella pertussis are available. Clinical picture is difficult to differentiate between the B. pertussis and viral respiratory infections. Methodology: Eighty-five patients with the diagnosis of WCLRTI were divided into 3 groups. Group 1 involved patients with pertussis shown by nasopharyngeal aspirate culture (NAC) and/or PCR. Group 2 consisted of patients who B. pertussis was not detected by NAC however, clinicians still evaluated them as potential patients of pertussis. Group 3 involved patients with the diagnosis of WCLRTI and those with VRTI detected by antigen detection/PCR. Results: Patients with pertussis had longer duration of the symptoms prior to admission. Paroxysmal cough, whooping, vomiting after coughing, cyanosis, apnea, seizures and abdominal hernias were more common in patients with pertussis. Fever, wheezing, tachypnea, retraction, fine crackles and rhonchi were more common in Group 3. Chest radiographs of patients in Group 3 revealed more bronchopneumonic infiltration, increased aeration, and atelectasis. CRP (C-reactive protein) and ESR (erythrocyte sedimentation rate) were significantly higher in Group 3. Of the patients 43.6% had no pertussis vaccination due to being < 2 months in age and 29.4% had 1 dose. Conclusions: Pertussis should be thought in differential diagnosis of children with complaints of episodes of paroxysmal cough, cough accompanied by gasping, vomiting after coughing; with leukocytosis, lymphocytosis and a normal chest X-ray. The majority of children with pertussis infection are those who have not had the opportunity for vaccination.

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“…Mahmoudi et al (3) found that RSV was the most frequently detected pathogen (20%), followed by adenovirus (16%), PIV (11%), and metapneumovirus (10%). Saiki-Macedo et al (4) performed a retrospective analysis of the etiology of pertussis-like syndrome in 288 children under 5 years old. The most frequently isolated pathogen was adenovirus (49%), followed by M. pneumoniae (26%) and influenza B virus (19.8%).…”

Section: Discussionmentioning

confidence: 99%