Identification and analysis of toxic phytochemicals

Salem, Mohamed A.; Serag, Ahmed; El‐Seedi, Hesham R.; Hamdan, Dalia I.; Ezzat, Shahira M.; Zayed, Ahmed

doi:10.1016/b978-0-12-821556-2.00015-3

Cited by 6 publications

(3 citation statements)

References 218 publications

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“…In experimental animals, lectins impair host resistance to infection, induce failure to flourish, and even cause death [ 216 ]. In addition to organ toxicities [ 217 ] and gastrointestinal tract discomfort [ 218 ], a number of these plants and their chemicals induce genotoxicity, which could result in carcinogenesis [ 219 ]. Similarly, a marine glycoprotein known as shrimp tropomyosin was demonstrated to induce serious allergic reaction in an animal model, which can be abolished by glycation [ 220 ] It is therefore important to be cautious in selecting only natural products which are validated to be safe and patients are not allergic to, as the consumption of natural products whose safety is not substantiated could pose risks to human health.…”

Section: Safety Concerns Of Applying Some Natural Products For Clinic...mentioning

confidence: 99%

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases

Okagu

Ezeorba

Aguchem

et al. 2022

IJMS

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The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects that include certain types of cancers and strokes, hence the ongoing quest for the discovery of alternatives with little or no side effects. Natural products (NPs), mainly of plant origin, have shown compelling promise in the treatments of BDs, with little or no side effects. However, the paucity in knowledge of the mechanisms behind their activities on bone remodeling has remained a hindrance to NPs’ adoption. This review discusses the pathological development of some BDs, the NP-targeted components, and the actions exerted on bone remodeling signaling pathways (e.g., Receptor Activator of Nuclear Factor κ B-ligand (RANKL)/monocyte/macrophage colony-stimulating factor (M-CSF)/osteoprotegerin (OPG), mitogen-activated protein kinase (MAPK)s/c-Jun N-terminal kinase (JNK)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), Kelch-like ECH-associated protein 1 (Keap-1)/nuclear factor erythroid 2–related factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1), Bone Morphogenetic Protein 2 (BMP2)-Wnt/β-catenin, PhosphatidylInositol 3-Kinase (PI3K)/protein kinase B (Akt)/Glycogen Synthase Kinase 3 Beta (GSK3β), and other signaling pathways). Although majority of the studies on the osteoprotective properties of NPs against BDs were conducted ex vivo and mostly on animals, the use of NPs for treating human BDs and the prospects for future development remain promising.

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Section: Safety Concerns Of Applying Some Natural Products For Clinic...mentioning

confidence: 99%

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases

Okagu

Ezeorba

Aguchem

et al. 2022

IJMS

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“…The protective effects of polydatin on damaged macrophages were also highlighted by Liu et al [ 37 ]. A more recent study also reviewed the pharmacological effects of polydatin in some diseases [ 38 ]. In the current mechanistic review, the therapeutic targets, pharmacological mechanisms, biological activities, and health benefits of polydatin are highlighted for all related biological/pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits

2022

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Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in inflammation, oxidative stress, and apoptosis. Various imperative biological activities have been suggested for polydatin towards promising therapeutic effects, including anticancer, cardioprotective, anti-diabetic, gastroprotective, hepatoprotective, neuroprotective, anti-microbial, as well as health-promoting roles on the renal system, the respiratory system, rheumatoid diseases, the skeletal system, and women’s health. In the present study, the therapeutic targets, biological activities, pharmacological mechanisms, and health benefits of polydatin are reviewed to provide new insights to researchers. The need to develop further clinical trials and novel delivery systems of polydatin is also considered to reveal new insights to researchers.

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“…These toxins are capable of damaging nerve cells even at low concentrations. As a result, there is a set consumption limit for glycoalkaloids in potatoes, which must be less than 200 mg/kg fresh weight or 1000 mg/kg dry weight (Salem et al, 2021). When the concentration of GAs in potatoes is higher than 100 mg/kg fresh weight, bitter taste, and throat, and mouth burning is reported.…”

mentioning

confidence: 99%

Use of magnetic fields reduces α‐chaconine, α‐solanine, and total glycoalkaloids in stored potatoes ( Solanum tuberosum L.)

Irungu

Tanga

Ndiritu

et al. 2022

Food Processing Preservation

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This work aimed to assess the suitability of magnetic fields (MF) to reduce glycoalkaloids (GAs) in stored potatoes. The effects of the source of magnetic fields (direct current [DC] and alternating current [AC]), magnetic field intensity (1, 2, and 3 mT), and storage type (dark store—herein referred to as the control store and a commercial store with varying light intensity) on quantities of GAs were investigated. Subjecting tubers to increasing levels of MF intensities and placing them in the control store led to a significant (p < .05) decrease in α‐chaconine and an increase in α‐solanine. However, storage of potatoes in the commercial store after exposure to increasing MF intensities led to a significant (p < .05) decrease in α‐solanine and an increase in α‐chaconine. The use of AC MF with an intensity of 2 mT resulted in a significant (p < .05) reduction in α‐chaconine, α‐solanine, and TG. Novelty impact statement Magnetic fields are an emerging non‐thermal technology that has wide potential in food processing applications. The findings in the current work revealed that magnetic fields can be used to reduce quantities of toxic glycoalkaloids in potatoes during storage, and thus improve their postharvest quality. The results offer practical insights on postharvest management of potatoes to ensure reduction of losses and thus positively impact food and nutritional security.

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Identification and analysis of toxic phytochemicals

Cited by 6 publications

References 218 publications

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases

Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits

Use of magnetic fields reduces α‐chaconine, α‐solanine, and total glycoalkaloids in stored potatoes ( Solanum tuberosum L.)

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