Identification and assessment of genetic diversity among Sargassum species from Egypt

Soliman, Mahmoud; Tawfik, Eman

doi:10.1007/s13237-020-00336-x

Cited by 4 publications

(1 citation statement)

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“…The algae was previously identified, according to Soliman and Tawfik ( Soliman and Tawfik, 2021 ), by the 18S rRNA gene as Sargassum subrepandum var. rueppellii by a homologous identity of 99% and deposited in Genbank with the accesssion number CH004439.…”

Section: Methodsmentioning

confidence: 99%

Phyto-synthesized silver nanoparticles from Sargassum subrepandum: anticancer, antimicrobial, and molluscicidal activities

El-Sayed,

Abdelsalam,

Morad

et al. 2024

Front. Plant Sci.

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In the realm of nanotechnology, the use of algae to produce nanoparticles is an environmentally friendly, sustainable, and economically viable strategy. In the present study, the brown macroalgae Sargassum subrepandum was utilized to effectively produce silver nanoparticles (AgNPs). Through various characterization techniques, the AgNPs’ structural integrity was confirmed. AgNPs exhibited significant antimicrobial activity against Pseudomonas aeruginosa and Fusarium equiseti. AgNPs showed cytotoxic effects on the MCF-7 breast adenocarcinoma cell line with an IC50 of 12.5 µg/ml. Treatment with AgNPs resulted in a marked reduction in cell viability, alongside evident apoptotic and necrotic morphological changes in the cancer cells. Through molecular docking studies, a deeper understanding of the interaction between AgNPs and crucial proteins related to cancer has been achieved, AgNPs showed a promising molluscicidal action on Biomphalaria alexandrina snails, a Schistosoma mansoni intermediate host. The half-lethal dose (LC50) of AgNPs was determined to be 0.84 mg/L. The potential consequences of its administration include potential disruptions to the glycolysis profile, as well as potential impacts on the steroidal hormone’s estrogen and testosterone and certain kidney function tests. This study highlights the diverse uses of algae-synthesized AgNPs, ranging from healthcare to environmental management, demonstrating their importance in advancing nano-biotechnological solutions.

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Section: Methodsmentioning

confidence: 99%