Identification and Characteristics of Co-isolation of Multiple Nontuberculous Mycobacteria

Asaoka, Masato; Hagiwara, Eri; Etori, Satoshi; Higa, Katsuyuki; Ikeda, Satoshi; Sekine, Akimasa; Kitamura, Hideya; Baba, Tomohisa; Komatsu, Shigeru; Ogura, Takashi

doi:10.2169/internalmedicine.5300-20

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…Our study, because we did not rely on multiple respiratory specimens for definition of coinfection, was not able to differentiate intermittent and chronic coinfection. Another retrospective study of 213 patients in Japan with non-MAC pulmonary disease found that 26.0% had multiple NTM species, which is a much higher rate of coinfection with other NTM [ 15 ] than seen in our study. The reason why some PMAC patients develop coinfection is not completely clear.…”

Section: Discussioncontrasting

confidence: 45%

Clinical Features and Treatment Outcomes of Pulmonary Mycobacterium avium-intracellulare Complex With and Without Coinfections

Wang

Stapleton

Baker

et al. 2022

Open Forum Infectious Diseases

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Section: Discussioncontrasting

confidence: 45%

Clinical Features and Treatment Outcomes of Pulmonary Mycobacterium avium-intracellulare Complex With and Without Coinfections

Wang

Stapleton

Baker

et al. 2022

Open Forum Infectious Diseases

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“…M.intrcellulare has been reported causing disease in a capybara subjected to stressful conditions and causing lesions similar to other pathogenic Mycobacteria ( 5 ). M. gordonae and M. terrae have been isolated from sputum samples in human patients with respiratory disease ( 3 , 57 ), but there are no reports of these agents' causing disease in domestic and wild animals. M. kumamotonense has been documented in immunocompetent individuals with latent tuberculosis and patients with multiple spiculated pulmonary nodules without respiratory symptoms ( 58 , 59 ).…”

Section: Discussionmentioning

confidence: 99%

Detection of non-tuberculous mycobacteria in native wildlife species at conservation risk of Argentina

Barandiaran,

Ponce,

Piras

et al. 2024

Front. Vet. Sci.

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IntroductionNon-tuberculous Mycobacteria (NTM) are mainly environmental but can cause opportunistic infections and diseases in humans and animals. Livestock and wild animals can be infected with NTM. In Argentina, there are native wild species facing conservation risks, and they are the focus of protection and reintroduction projects designed to preserve biodiversity in various ecoregions. The aim of this study was to report the presence of NTM in samples collected from four endangered native wild species from nine Argentine provinces, as part of their pre-release health assessment.MethodsA total of 165 samples from giant anteater, peccary, tapir and pampas deer were obtained, these included either bronchoalveolar or endotracheal lavages, or oropharyngeal, nasopharyngeal or tracheal swabs. Bacteriological culture followed by molecular identification and sequencing were performed.ResultsA total of 27 NTM were detected, including Mycobacterium avium subsp. hominissuis, M. intracellulare, M. terrae, M. gordonense, M. kumamotonense, M. fortuitum, M. saskatchewanense, and M. genavense. Results revealed a 16,36% NTM recovery rate, with the giant anteater showing the highest prevalence among the mammals under study.DiscussionIn Argentina, due to extensive production systems, the interaction between domestic and wild species sharing the same environment is frequent, increasing the exposure of all the species to these NTM. In this way, the transmission of infectious agents from one to another is feasible. Moreover, NTMs might interfere with the diagnosis of bovine tuberculosis and paratuberculosis. These findings emphasize the importance of active health surveillance in conservation programs. It highlights the need to address NTM epidemiology in wildlife and its impact on conservation and public health.

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“…For instance, chronic obstructive PD and age ≥ 65 years were associated with the isolation of multiple NTM species in a Singapore study. 15 Asaoka et al 27 observed 55 (26%) cases of multiple NTM species isolated from 213 non-MAC-PD patients, in which co-identification was more prevalent in women, never-smokers, and those with fewer cavitary presentations. Meanwhile, another study reported single and mixed infections in 120 patients with MAC; however, mixed NTM infections were associated with male sex and a history of asthma.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Treatment Outcomes of Pulmonary Diseases Caused by Coinfections With Multiple Nontuberculous Mycobacterial Species

Kim,

Woo,

Yong

et al. 2024

J Korean Med Sci

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Background Coinfections with multiple nontuberculous mycobacterial (NTM) species have not been widely studied. We aimed to evaluate the clinical characteristics and treatment outcomes in patients with NTM-pulmonary disease (PD) caused by coinfection with multiple NTM species. Methods We retrospectively reviewed patients with NTM-PD at a tertiary referral hospital in Korea between March 2012 and December 2018. Coinfection was defined as two or more species of NTM pathogens isolated from the same respiratory specimen or different specimens within three months. Results Among 1,009 patients with NTM-PD, 147 (14.6%) NTM coinfections were observed (average age 64.7 years, 69.4% women). NTM species were identified more frequently (median 6 vs. 3 times, P < 0.001) in the coinfection group than in the single species group, and follow-up duration was also longer in the coinfection group (median 44.9 vs. 27.1 months, P < 0.001). Mycobacterium avium complex (MAC) and M. abscessus and M. massiliense (MAB) were the dominant combinations (n = 71, 48.3%). For patients treated for over six months in the MAC plus MAB group (n = 31), sputum culture conversion and microbiological cure were achieved in 67.7% and 41.9% of patients, respectively. We divided the MAC plus MAB coinfection group into three subgroups according to the target mycobacteria; however, no statistical differences were found in the treatment outcomes. Conclusion In NTM-PD cases, a significant number of multiple NTM species coinfections occurred. Proper identification of all cultured NTM species through follow-up is necessary to detect multispecies coinfections. Further research is needed to understand the nature of NTM-PD in such cases.

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Identification and Characteristics of Co-isolation of Multiple Nontuberculous Mycobacteria

Cited by 6 publications

References 13 publications

Clinical Features and Treatment Outcomes of Pulmonary Mycobacterium avium-intracellulare Complex With and Without Coinfections

Clinical Features and Treatment Outcomes of Pulmonary Mycobacterium avium-intracellulare Complex With and Without Coinfections

Detection of non-tuberculous mycobacteria in native wildlife species at conservation risk of Argentina

Clinical Characteristics and Treatment Outcomes of Pulmonary Diseases Caused by Coinfections With Multiple Nontuberculous Mycobacterial Species

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