Identification and characterization of three CXC chemokines in Asian swamp eel (Monopterus albus) uncovers a third CXCL11_like group in fish

Yuan, Hao; Li, Youshen; Han, Panpan; Tian, Guangming; Zhang, Wenbing; Zhang, Shun-cong; Xu, Qiaoqing; Wang, Tiehui

doi:10.1016/j.dci.2019.103454

Cited by 16 publications

(3 citation statements)

References 54 publications

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“…Chemokines are a family of small secreted cytokines that control the migration of white blood cells to sites of infection or tissue injury 1,3 . These molecules interact with target cells through GPCR and have been classified into four subfamilies: CXC, CC, CX3C, and XC according to specific structural characteristics 3 . Here, we identify a family of mammalian cell chemoattractants from saliva of sand flies.…”

Section: Discussionmentioning

confidence: 99%

“…hemokines are vertebrate-derived cytokines that attract immune cells and are members of the CC or CXC family of proteins 1,2 . These proteins have been identified in most vertebrates including zebra fish and mammals 3 . In insects, chemoattractant molecules are a family of proteins that attract insect cells, including hemocytes, and possess a unique structure and sequence that does not resemble vertebrate chemokines 4,5 .…”

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A sand fly salivary protein acts as a neutrophil chemoattractant

et al. 2021

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Apart from bacterial formyl peptides or viral chemokine mimicry, a non-vertebrate or insect protein that directly attracts mammalian innate cells such as neutrophils has not been molecularly characterized. Here, we show that members of sand fly yellow salivary proteins induce in vitro chemotaxis of mouse, canine and human neutrophils in transwell migration or EZ-TAXIScan assays. We demonstrate murine neutrophil recruitment in vivo using flow cytometry and two-photon intravital microscopy in Lysozyme-M-eGFP transgenic mice. We establish that the structure of this ~ 45 kDa neutrophil chemotactic protein does not resemble that of known chemokines. This chemoattractant acts through a G-protein-coupled receptor and is dependent on calcium influx. Of significance, this chemoattractant protein enhances lesion pathology (P < 0.0001) and increases parasite burden (P < 0.001) in mice upon co-injection with Leishmania parasites, underlining the impact of the sand fly salivary yellow proteins on disease outcome. These findings show that some arthropod vector-derived factors, such as this chemotactic salivary protein, activate rather than inhibit the host innate immune response, and that pathogens take advantage of these inflammatory responses to establish in the host.

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confidence: 99%

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A sand fly salivary protein acts as a neutrophil chemoattractant

et al. 2021

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“…In addition to this function in immunity, chemokines play important roles in normal development and growth, such as embryonic development, angiogenesis and organogenesis (Arenberg et al, 1997;Baoprasertkul et al, 2005;Zhou et al, 2018), and in tumour growth and metastasis (Ghadjar et al, 2009;Benkheil et al, 2018). According to the arrangement of cysteine residues in the N-terminal region, they can be divided into five subfamilies, CXC, CC, CX3C, XC and CX (fish specific) (Bacon et al, 2002;Lally et al, 2003;Nomiyama et al, 2008;Chen et al, 2013;Yuan et al, 2019). The CC and CXC subfamilies represent the two largest groups of chemokines.…”

Section: Introductionmentioning

confidence: 99%

Expansion of fish CCL20_like chemokines by genome and local gene duplication: Characterisation and expression analysis of 10 CCL20_like chemokines in rainbow trout (Oncorhynchus mykiss)

Liu

Wang

et al. 2020

Developmental & Comparative Immunology

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Transcriptome Analysis of the Spleen Provides Insight into the Immune Regulation of GCRV Resistance in Grass Carp (Ctenopharyngodon idella)

Jiang

et al. 2023

Mar Biotechnol

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Identification and characterization of three CXC chemokines in Asian swamp eel (Monopterus albus) uncovers a third CXCL11_like group in fish

Cited by 16 publications

References 54 publications

A sand fly salivary protein acts as a neutrophil chemoattractant

A sand fly salivary protein acts as a neutrophil chemoattractant

Expansion of fish CCL20_like chemokines by genome and local gene duplication: Characterisation and expression analysis of 10 CCL20_like chemokines in rainbow trout (Oncorhynchus mykiss)

Transcriptome Analysis of the Spleen Provides Insight into the Immune Regulation of GCRV Resistance in Grass Carp (Ctenopharyngodon idella)

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