2008
DOI: 10.1073/pnas.0802203105
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Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

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Cited by 1,726 publications
(2,475 citation statements)
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References 34 publications
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“…We saw evidence for early sequence evolution in the infant. Replication after sexual transmission revealed the stochastic incorporation of neutral mutations within the viral population (24). Beyond these stochastic sequence changes we were able to detect mutations becoming fixed and also examples of clustered mutations.…”
Section: Discussionmentioning
confidence: 57%
“…We saw evidence for early sequence evolution in the infant. Replication after sexual transmission revealed the stochastic incorporation of neutral mutations within the viral population (24). Beyond these stochastic sequence changes we were able to detect mutations becoming fixed and also examples of clustered mutations.…”
Section: Discussionmentioning
confidence: 57%
“…This estimate of 3 T/F genomes responsible for productive clinical infection is a minimum estimate, whose accuracy and precision are based on the numbers of sequences determined at the earliest sampling time points. In this subject, we determined 65 sequences in the initial 46 days of infection; previously described statistical power calculations (35) indicate that this provides a >95% probability of detecting minor variant sequences present at a frequency of at least 5%. Two of these viral lineages, T/F 1 and T/F 2, persisted and diversified over the next two sampling time points before they were apparently extinguished.…”
Section: Resultsmentioning
confidence: 99%
“…In many cases, a single transmitted/founder virus establishes infection and then evolves within the host resulting in a diverse virus population 38. The earliest changes to the virus population are driven by the CD8 + T‐cell response that is induced as viremia increases39 and places strong selection pressure on the virus, resulting in complete turnover of the virus pool within the first few weeks of infection 40.…”
Section: Development Of Broadly Neutralizing Antibodies In Hiv‐1 Infementioning
confidence: 99%