2018
DOI: 10.1111/tbed.13038
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Identification and characterization of vaccine candidates againstHyalomma anatolicum—Vector of Crimean‐Congo haemorrhagic fever virus

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Cited by 28 publications
(31 citation statements)
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“…Focusing on functionally relevant biological processes and proteins, such as tick attachment and feeding, proteases and protease inhibitors at the tick-host interface, water balance, blood digestion, heme and iron metabolism, detoxification, mating, vitellogenesis, and fertility, allowed the identification of candidate vaccine tick protective antigens [26,37]. Some of these antigens, such as Aquaporin [37][38][39][40], Ferritin [41][42][43][44], and 64TRP cement protein [45,46], have shown efficacy in vaccine formulations for the control of tick infestations, thus providing support for the potential of this predictive model for the identification of candidate protective antigens. Nevertheless, these experiments were conducted in mammalian animal models, which show differences in the immune response when compared to fish [47].…”
Section: Discussionmentioning
confidence: 99%
“…Focusing on functionally relevant biological processes and proteins, such as tick attachment and feeding, proteases and protease inhibitors at the tick-host interface, water balance, blood digestion, heme and iron metabolism, detoxification, mating, vitellogenesis, and fertility, allowed the identification of candidate vaccine tick protective antigens [26,37]. Some of these antigens, such as Aquaporin [37][38][39][40], Ferritin [41][42][43][44], and 64TRP cement protein [45,46], have shown efficacy in vaccine formulations for the control of tick infestations, thus providing support for the potential of this predictive model for the identification of candidate protective antigens. Nevertheless, these experiments were conducted in mammalian animal models, which show differences in the immune response when compared to fish [47].…”
Section: Discussionmentioning
confidence: 99%
“…A very low level of variation of 0.6-2.4 %, 0.3-1.8 %, 0.3 to 6.4, 0.1-0.6% and 0.1-1.3 % in the deduced amino acid sequences of various field isolates of H. anatolicum was observed in SUB, CRT, CathL, FER2 and TPM genes, respectively. Similarly, the amino acid sequence identity for the same genes in other ticks species was 77.4-99.3 %, 85.1-99.7 %, 57.5-89.5 %, 80.1-90.9 % and 98.8-99.9 % against reference H. anatolicum IVRI II strain (Kumar et al, 2017;Manjunathachar et al, 2019).…”
Section: Immunization Of Hostsmentioning
confidence: 78%
“…The functional properties of the genes were studied by RNA interference (RNAi) technology and following immunization of animals with recombinant proteins, SUB, TPM, FER2, CRT and CathL, 65.4%, 63.7%, 51.7 %, 41.3% and 30.2%, respectively, protection against larvae was observed. However, against adults, the TPM and FER2 proteins were more effective ( Kumar et al., 2017 ; Manjunathachar et al., 2019 ). The results of different immunization studies clearly indicated that the majority of the experiments were conducted using the homologous challenge system and the protective efficacy of the antigens was variable.…”
Section: Management Of Hyalomma Speciesmentioning
confidence: 99%
“…Both vaccine candidates showed partial protection of immunized cross-bred male calves against challenge tick infestations (51.2–66.4%). However, their direct effect on virus transmission by a challenge with CCHFV-infected ticks has not been assessed [94]. So far, only two candidates have been evaluated for their direct effect on virus transmission, both in connection with TBEV.…”
Section: Tick-borne Encephalitis Virus (Tbev)mentioning
confidence: 99%