Identification and diversity of Y‐chromosome haplotypes in Qinghai yak populations

J., Z.; Xia, Xiaoting; Chen, S. M.; Zhao, Xiaomin; Zeng, Lingfeng; Xie, Yangjie; Chao, Steven; Xu, Jin; Sun, Yonggang; Li, R. Z.; Guanque, Z. X.; Han, Jianlin; Lei, Chuzhao

doi:10.1111/age.12723

Cited by 18 publications

(15 citation statements)

References 17 publications

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“…There is a special climate, comprised of a lower average annual temperature and rainfall that fluctuates, therefore, a variety of unique livestock are grazed there [25]. Among these livestock, the yak (Bos grunniens), which belongs to the bovine species, can survive in extreme environmental conditions, such as cold, harsh, and oxygen-poor [26]. The Qinghai plateau, located on the northeastern side of the QTPA, has a unique and vigorous natural ecosystem because of its high altitude, cold climate, and oxygen deficiency [27].…”

Section: Introductionmentioning

confidence: 99%

Human Spotted Fever Group Rickettsia Infecting Yaks (Bos grunniens) in the Qinghai-Tibetan Plateau Area

Jian

Moumouni

et al. 2020

Pathogens

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The Qinghai-Tibetan Plateau Area (QTPA) is a plateau with the highest average altitude, located in Northwestern China. There is a risk for interspecies disease transmission, such as spotted fever rickettsioses. However, information on the molecular characteristics of the spotted fever group (SFG) Rickettsia spp. in the area is limited. This study performed screenings, and detected the DNA of human pathogen, SFG Rickettsia spp., with 11.3% (25/222) infection rates in yaks (Bos grunniens). BLASTn analysis revealed that the Rickettsia sequences obtained shared 94.3–100% identity with isolates of Rickettsia spp. from ticks in China. One Rickettsia sequence (MN536161) had 100% nucleotide identity to two R. raoultii isolates from Chinese Homo sapiens, and one isolate from Qinghai Dermacentor silvarum. Meanwhile, another Rickettsia sequence (MN536157) shared 99.1–99.5% identity to one isolate from Dermacentor spp. in China. Furthermore, the phylogenetic analysis of SFG Rickettsia spp. ompA gene revealed that these two sequences obtained from yaks in the present study grouped with the R. slovaca and R. raoultii clades with isolates identified from Dermacentor spp. and Homo sapiens. Our findings showed the first evidence of human pathogen DNA, SFG Rickettsia spp., from animals, in the QTPA.

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Section: Introductionmentioning

confidence: 99%

Human Spotted Fever Group Rickettsia Infecting Yaks (Bos grunniens) in the Qinghai-Tibetan Plateau Area

Jian

Moumouni

et al. 2020

Pathogens

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“…It has been used to explore the paternal genetic diversity, origin and population genetic structure of domestic animals. In recent years, two kinds of molecular markers including Y chromosome microsatellites (Y-STRs) and single nucleotide polymorphisms (Y-SNPs) had been used to study the yak paternal population genetics which showed that Chinese yak breeds/populations own rich paternal genetic diversity with two different lineages [6][7][8][9][10] . In our recent maternal genetic study, we found that each of three Chinese white yak breeds/populations (Menyuan, Huzhu and Tianzhu) owned special maternal genetic information with relatively rich genetic diversity 11 .…”

Section: Introductionmentioning

confidence: 99%

Paternal genetic diversity, differentiation and phylogeny of three white yak breeds/populations in China

Luo

Wei

Liu

et al. 2022

Preprint

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The white yak, a unique and valuable farm animal of the Qinghai-Tibetian Plateau, is mainly distributed in Tianzhu (County of Gansu Province), Menyuan, Huzhu and Ledu (three Counties of Qinghai Province) in China. In the present study, the Y-chromosomal based genetic diversity, differentiation and phylogeny of three Chinese white yak breeds/populations (Tianzhu, Huzhu and Menyuan) were comprehensively explored using five Y-SNPs (SRY4, USP9Y, UTY19, AMELY3 and OFD1Y10) and one Y-STR (INRA189) markers. The results of this study showed that six Y-haplotypes (H1Y1, H9Y1, H10Y1, H11Y2, H12Y2 and H13Y2) were identified in 97 male yaks from three white yak breeds/populations. Among haplotypes, H1Y1, H10Y1 and H11Y2 were shared haplotypes for all of breeds/populations and H12Y2 was shared by Tianzhu and Huzhu populations. However, H9Y1 and H13Y2 haplotypes were only detected in Menyuan and Tianzhu white yak populations, respectively. The Y-haplotype diversity was maximum in Huzhu white yak (0.7500±0.0349), the medium in Tianzhu white yak (0.6881±0.0614) and lowest in Menyuan white yak (0.5720±0.0657), respectively. The total Y-haplotype diversity of three white yak breeds/populations was 0.7567±0.0233, indicating rich paternal genetic diversity in white yak. The FST values showed a moderate differentiation between Tianzhu and Menyuan (FST =0.0763, P<0.05) populations, weak differentiation between Huzhu and Tianzhu white yak breeds/populations (FST =0.0186, P>0.05) and Huzhu and Menyuan (FST =-0.005, P>0.05) populations. The clustering analysis showed a close genetic relationship between Huzhu and Menyuan white yaks and far from Tianzhu white yak breed. The phylogenetic analyses showed that white yak had two Y-haplogroups/lineages (Y1 and Y2) with two potential paternal origins. The data of present study could contribute to the conservation and utilization of special white yak genetic resources.

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“…Qinghai province is located in the northern QTP and is home to abundant yak genetic resources. Archeological analyses and assessments of mitochondrial DNA (mtDNA) sequences suggest that Qinghai province may be the origin or site of yak domestication [10]. However, further research is warranted to better clarify the maternal origins, phylogenetic structure, and diversity of domestic yak populations by studying the yak mitochondrial genome.…”

Section: Introductionmentioning

confidence: 99%

Mitogenomic Diversity and Maternal Origins of Yak (Bos Grunniens)

Wang¹,

Pei²,

Bao³

et al. 2021

Preprint

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Background and aim: Mitochondrial genome has the characteristics of simple structure, no recombination, maternal inheritance, high conservation, fast evolution, and high copy number. It is easy to sequence, contains high resolution phylogenetic information, and exists in a wide range of taxa. Theref ore, it is widely used in the study of biological phylogeny. At present, phylogenetic studies focus mainly on D loop region, cytochrome b gene, and protein coding sequence; phylogenetic studies using the mitochondrial complete sequence are rare. Therefore, this study aimed to conduct phylogenetic experiments using the mitochondrial complete sequence and compare the results with previous findings obtained using partial sequences. Results: Complete mitochondrial sequences of five yak populations from Qinghai and Xinjiang were obtained. The haplotype diversity of the five populations were Xueduo yak (0.992 ± 0.015), Pamir yak (0.990 ± 0.014), Yushu yak (0.963 ± 0.033), Qilian yak (0.948 ± 0.036), and Huanhu yak (0.905 ± 0.048), which showed a higher haplotype diversity compared with other breeds. A total of 78 haplotypes were obtained from 111 individuals. Among these, Yushu yak, Huanhu yak, Xueduo yak, and Qilian yak all shared haplotypes, but the Pamir yak did not share haplotypes with these four populations. Phylogenetic analysis showed that yak populations were separable into three distinct branches. The analysis identified a new phylogenetic branch with both wild and domestic yaks being represented in the new branch. The 155 haplotypes were divided into 6 haplotype groups by haplotype clustering. The haplotype group had nothing to do with the morphological group of yaks, and yaks from the same population or the same ecological group were distributed in different haplotype groups. The four haplotype groups A, B, C, and D, showed a star-shaped distribution of haplotypes. The central haplotypes were widely distributed and had a high frequency Conclusions: T he genetic diversity of yaks in Qinghai was high. Both domestic and wild yaks exhibited three different mat ernal origins. Three different maternal origins existed in ancient wild yaks before domestication, with haplogroup A being the primary haplogroup associated with yak domestication.

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Identification and diversity of Y‐chromosome haplotypes in Qinghai yak populations

Cited by 18 publications

References 17 publications

Human Spotted Fever Group Rickettsia Infecting Yaks (Bos grunniens) in the Qinghai-Tibetan Plateau Area

Human Spotted Fever Group Rickettsia Infecting Yaks (Bos grunniens) in the Qinghai-Tibetan Plateau Area

Paternal genetic diversity, differentiation and phylogeny of three white yak breeds/populations in China

Mitogenomic Diversity and Maternal Origins of Yak (Bos Grunniens)

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