Identification and In vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH

The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility

“…Our understanding of follicle biology is currently incomplete and consequently the possibility of tailored ovarian stimulation procedures, based upon transcriptomic analysis of follicular cells, might seem like a distant prospect. However, a study carried out by Gerasimova et al (2010) demonstrates that optimization of COS, guided by the results of genetic analysis might not be far off. The authors examined the genetic constitution of the FSH receptor (FSHR) in relation to female infertility and response to COS.…”

“…The presence of these variants is indicative of a possible genetic basis for certain forms of female infertility. They also provide a potential biological explanation for some cases of ovarian hyperstimultion syndrome and other cases in which COS fails to elicit an adequate response (Gerasimova et al, 2010).…”

“…However, they also clearly show that the transcriptomic behaviour of follicular cells is influenced by a variety of factors. These include the stage of maturation of the developing oocyte (Ouandaogo et al, 2011;Feuerstein et al, 2012), the type of COS employed during ART (Adriaenssens et al, 2010;Gerasimova et al, 2010;de los Santos et al, 2012), the female age (McReynolds et al, 2012;Pacella et al, 2012) and the chromosome constitution of the enclosed oocyte (Fragouli et al, 2012).…”

Distribution of FSHR-29 polymorphism among women with polycystic ovary syndrome and association with level of its receptor expression in Granulosa cells of infertile women

“…Follicle stimulating hormone (FSH) plays a central role in oogenesis, where its main effects are related to granulosa cell proliferation, oocyte maturation, recruitment of the dominant follicle, and estrogen synthesis via activation of the aromatase gene (1,2). It is well established that the physiological action of FSH depends on the activation of its receptor (FSHR), localized in granulosa and sertoli cells (3). FSHR acts by binding to the subgroup of G-protein coupled receptor (4) and is divided by the intracellular domain, transmembrane region, and extracellular domain, which consist of ten exons and nine introns at chromosome 2p21 ( 5 .…”