Identification and quantification of potential metabolites of Gd-based contrast agents by electrochemistry/separations/mass spectrometry

Telgmann, Lena; Faber, Helene; Jahn, Sandra; Melles, Daniel; Simon, Hannah; Sperling, Michael; Kärst, Uwe

doi:10.1016/j.chroma.2012.03.088

Cited by 38 publications

(17 citation statements)

References 48 publications

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“…[9] The use of Gd complexes as CAs in diagnostic medicine has recognized issues because free Gd 3 + is toxic; [10] for example, a connection between the use of Gd CAs and the development of potentially fatal nephrogenic systemic fibrosis (NSF) has been demonstrated. [11] It is therefore mandatory to have the capability to monitor the stability and reactions of these complexes, such as demetalation kinetics. Currently available methods, based either on the separation and analysis of the gadolinium complexes [11,12] or on relaxometry measurements of the water signal, [13] do not allow direct studies.…”

Section: Introductionmentioning

confidence: 99%

“…[11] It is therefore mandatory to have the capability to monitor the stability and reactions of these complexes, such as demetalation kinetics. Currently available methods, based either on the separation and analysis of the gadolinium complexes [11,12] or on relaxometry measurements of the water signal, [13] do not allow direct studies. On the contrary, direct detection of structurally relevant NMR signals from gadolinium complexes (i.e., those that may provide structural or dynamic information) would allow the system to be investigated under the conditions of interest.…”

Section: Introductionmentioning

confidence: 99%

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Direct Detection of ¹⁷O in [Gd(DOTA)]⁻ by NMR Spectroscopy

Fusaro

Casella

Bagno

2014

Chemistry A European J

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The (17) O NMR spectrum of the non-coordinated carboxyl oxygen in the Gd(III) -DOTA (DOTA=tetraazacyclododecanetetraacetic acid) complex has been observed experimentally. Its line width is essentially unaffected by paramagnetic relaxation due to gadolinium, and is only affected by the quadrupole pathway. The results are supported by the relevant parameters (hyperfine and quadrupole coupling constants) calculated by relativistic DFT methods. This finding opens up new avenues for investigating the structure and reactivity of paramagnetic Gd(III) complexes used as contrast agents in magnetic resonance imaging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Direct Detection of ¹⁷O in [Gd(DOTA)]⁻ by NMR Spectroscopy

Fusaro

Casella

Bagno

2014

Chemistry A European J

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“…The same mechanism was confirmed for other nucleosides and nucleotides [10]. Telgmann et al [49] investigated metabolic pathways of Gd-based contrast agents, commonly used in magnetic resonance imaging. Electrochemically generated oxidation products were separated by either CE or LC and detected by ESI-MS and ICP-MS.…”

Section: Biomolecule Modificationmentioning

confidence: 54%

Hyphenation of Electrochemistry with Mass Spectrometry for Bioanalytical Studies

Cindric

Matysik

2013

Advances in Chemical Bioanalysis

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Hyphenation of electrochemistry (EC) and mass spectrometry (MS) is a growing research field with particular importance for bioanalytical applications. It opens the way for studying reaction mechanisms and metabolic pathways of biological compounds and drugs. Electrochemical conversion of sample molecules prior to MS analysis gives rise to short-lived intermediates and products naturally occurring in biological systems, which leads to better understanding of physiological processes. Numerous interesting and attractive studies in this field have been published so far demonstrating potential of EC-MS coupling. The combination with separation system such as liquid chromatography or capillary electrophoresis widens the scope of application providing additional information about compounds of interest. The combination of EC with liquid chromatography has been the most frequently used hyphenated system due to the simplicity of coupling to mass spectrometric detection. In terms of bioanalytical applications capillary electrophoresis offers some advantages and is a complementary technique to liquid chromatography. This review summarizes recent developments in this field from both instrumental and application perspectives. A rather new approach of coupling electrochemistry-capillary electrophoresis-mass spectrometry and its potential for bioanalysis is presented.

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“…The approach reveals the speciation changes of the Ru drug bound to holo‐transferrin in simulated cancer cytosol. Since contrast agents for magnetic resonance imaging based on Gd can trigger nephrogenic systemic fibrosis, a disease exclusively observed for several hundred dialysis patients after delivery of the agents, their metabolic pathways were examined by several methods including CE‐ICP‐MS . Nguyen et al.…”

Section: Development Of Methodology and Instrumentationmentioning

confidence: 99%

Recent advances in combination of capillary electrophoresis with mass spectrometry: Methodology and theory

Klepárnı́k

2014

Electrophoresis

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This review focuses on the latest development of microseparation electromigration methods in capillaries and microfluidic devices with MS detection and identification. A wide selection of 183 relevant articles covers the literature published from June 2012 till May 2014 as a continuation of the review article on the same topic by Kleparnik [Electrophoresis 2013, 34, 70-86]. Special attention is paid to the new improvements in the theory of instrumentation and methodology of MS interfacing with capillary versions of zone electrophoresis, ITP, and IEF. Ionization methods in MS include ESI, MALDI, and ICP. Although the main attention is paid to the development of instrumentation and methodology, representative examples illustrate also applications in the proteomics, glycomics, metabolomics, biomarker research, forensics, pharmacology, food analysis, and single-cell analysis. The combinations of MS with capillary versions of electrochromatography and micellar electrokinetic chromatography are not included.

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Identification and quantification of potential metabolites of Gd-based contrast agents by electrochemistry/separations/mass spectrometry

Cited by 38 publications

References 48 publications

Direct Detection of ¹⁷O in [Gd(DOTA)]⁻ by NMR Spectroscopy

Direct Detection of ¹⁷O in [Gd(DOTA)]⁻ by NMR Spectroscopy

Hyphenation of Electrochemistry with Mass Spectrometry for Bioanalytical Studies

Recent advances in combination of capillary electrophoresis with mass spectrometry: Methodology and theory

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Identification and quantification of potential metabolites of Gd-based contrast agents by electrochemistry/separations/mass spectrometry

Cited by 38 publications

References 48 publications

Direct Detection of 17O in [Gd(DOTA)]− by NMR Spectroscopy

Direct Detection of 17O in [Gd(DOTA)]− by NMR Spectroscopy

Hyphenation of Electrochemistry with Mass Spectrometry for Bioanalytical Studies

Recent advances in combination of capillary electrophoresis with mass spectrometry: Methodology and theory

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Product

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Direct Detection of ¹⁷O in [Gd(DOTA)]⁻ by NMR Spectroscopy

Direct Detection of ¹⁷O in [Gd(DOTA)]⁻ by NMR Spectroscopy