Identification and quantitation of cis-ketoconazole impurity by capillary zone electrophoresis–mass spectrometry

Castro-Puyana, María; García-Ruiz, Carmen; Cifuentes, Alejandro; Crego, Antonio L.; Marina, Marı́a Luisa

doi:10.1016/j.chroma.2006.02.030

Cited by 23 publications

(13 citation statements)

References 17 publications

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“…When no MS signal was detected for ESI voltage lower than 1500 V, a deep increase in I MS occurred (ca. 13 times increase from 2000 to 4000 V), the general evolution of which being in accordance with literature [30][31][32]. This deep increase evidences the strong influence of ESI voltage on ionization/desorption.…”

Section: Skimmer and Esi Voltagessupporting

confidence: 89%

“…Above 2001C, a deep increase in I MS appears as compared with I UV with a maximum for 3001C, (whereas N MS presents a minimum at 3001C). This tendency was already observed [32]. Especially, upon varying temperature from 250 to 3001C, an increase in I UV by 8% and in I MS by 180% occurs, that can be mainly explained by an increase in ionization efficiency.…”

Section: Dg Temperature and Flow Ratesupporting

confidence: 51%

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New insight into suction and dilution effects in CE coupled to MS via an ESI interface. II – Dilution effect

et al. 2009

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The hyphenation of CE with MS is nowadays accepted as a powerful analytical approach. As far as ESI, the most common interface, is concerned, one challenge is to provide the most sensitive as well as quantitative information, which is quite a difficult task, as it is linked, among other factors, to suction and dilution effects. In the coaxial ESI configuration, it has been previously demonstrated that suction effect depends on many parameters inherent to the ESI interface geometry, the prevailing ones being the CE capillary protrusion from the interface needle, the sheath liquid (SL) and the overall BGE flow rates and velocity profile. In this paper, dilution effect is studied, as the CE electrolyte is mixed with SL at the interface. Considering peak intensity and efficiency, this effect was studied as a function of the various parameters of the interface (capillary protrusion from the SL tube, nebulizing gas, SL and CE electrolyte flow rates) or of the source (skimmer and ESI voltages, drying gas flow rate and temperature). It appears that the dilution effect seems slightly lower than what can be anticipated from the proportions of the liquid flow rates. This study also indicates that suction effect has to be considered first to better understand the dilution phenomenon, as suction effect leads to an increase in peak intensity, before a dilution effect appears.

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Section: Skimmer and Esi Voltagessupporting

confidence: 89%

Section: Dg Temperature and Flow Ratesupporting

confidence: 51%

New insight into suction and dilution effects in CE coupled to MS via an ESI interface. II – Dilution effect

et al. 2009

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“…Although these values could be considered high, they are the result of the poor robustness offered by the classical 3D quadrupole IT (Paul trap) analyzer used in this work [31]. Thus, similar results have been reported in other works using CE-MS with this type of analyzer [20,21,32]. The LOD and LOQ for Orn enantiomers were calculated as the minimum analyte concentration yielding an S/N ratio equal to 3 and 10 times, respectively.…”

Section: Analytical Characteristics Of the Ce-ms 2 Chiral Methodsmentioning

confidence: 56%

Development of a CE‐ESI‐ITMS method for the enantiomeric determination of the non‐protein amino acid ornithine

et al. 2009

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Unequivocal enantiomeric determination by CE-MS2 of the non-protein amino acid ornithine (Orn), previously derivatized with FITC, was carried out in this work. A CE-tandem MS system was used to combine the potential of CE in chiral separations with the sensitivity and selectivity of tandem MS detection. The electrospray-coaxial sheath flow interface conditions were optimized and an IT analyzer working in the MS2 mode was employed to provide the best sensitivity and selectivity. Satisfactory results were obtained in terms of linearity (r2 > 0.99), precision (RSD from 1.3 to 2.3% for migration times and from 11.0 to 18.6% for corrected peak areas), and LOD (2 x 10(-9) M). Interestingly, the CE-MS2 method developed allowed a sensitivity enhancement of 100 folds with respect to UV detection. The results demonstrated the feasibility for carrying out quantitative CE-ESI-MS2 determinations of Orn enantiomers in beers. Thus, L-Orn was found in the 16 beer samples analyzed at concentrations ranging from 1 x 10(-6) to 2 x 10(-5) M, whereas the percentages of D-Orn with respect to the total amount of Orn reached values between 1.5 and 10.0%.

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“…The authors used UV and MS detections and reported the impurities found in three pharmaceutical formulations [98]. Table 2).…”

Section: Chemotherapeutic Agentsmentioning

confidence: 98%

Impurity analysis of pharmaceuticals using capillary electromigration methods

Jouyban

Kenndler

2008

Electrophoresis

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This review deals with the determination of impurities in pharmaceuticals by electromigration methods in the capillary format. These separation methods are either based on the different effective mobility of the charged analytes (as in zone electrophoresis and isotachophoresis) or include hybrid methods such as micellar electrokinetic chromatography, microemulsion electrokinetic chromatography and electrochromatography. The pharmaceutically active compounds under consideration belong to chemotherapeutic agents, central nervous system drugs, histamine receptor drugs, cardiovascular drugs, anticancer drugs, anti-inflammatory drugs and some other drugs. The review discusses about 150 publications from the period between 1980 and 2007 with special emphasis on the recent trends and gives details about the experimental conditions applied for analyses and the obtained analytical performance parameters.

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Identification and quantitation of cis-ketoconazole impurity by capillary zone electrophoresis–mass spectrometry

Cited by 23 publications

References 17 publications

New insight into suction and dilution effects in CE coupled to MS via an ESI interface. II – Dilution effect

New insight into suction and dilution effects in CE coupled to MS via an ESI interface. II – Dilution effect

Development of a CE‐ESI‐ITMS method for the enantiomeric determination of the non‐protein amino acid ornithine

Impurity analysis of pharmaceuticals using capillary electromigration methods

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