Identification and synthesis of novel biomaterials based on spider structural silk fibers

Hsia, Yang; Gnesa, Eric; Tang, Simon Y.; Jeffery, Felicia; Geurts, Paul; Zhao, Liang; Franz, Andreas H.; Vierra, Craig

doi:10.1007/s00339-011-6621-8

Cited by 3 publications

(2 citation statements)

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“…Porosity and other properties of the silk-based foams can be tailored to desired properties according to the surrounding tissues, even up to highly porous scaffolds [ 110 ]. Porous materials with a high toughness of incorporated fibers can absorb a high quantity of mechanical energy [ 18 ], which recommends them for the construction of bone tissue scaffolds.…”

Section: Spider Silk Structuresmentioning

confidence: 99%

“…In ancient times, spider silk was used to stop bleeding, where it served as an astringent [ 15 , 16 ]. The first clinical use of spider silk was in the 18th century, when it was used for suturing, whereas nowadays the application of silk as a biomaterial has been widely studied due to its excellent biocompatibility, high toughness, and ability to support tissue growth, especially for bone and ligament tissues [ 17 , 18 ]. Silk is one of the toughest natural materials and its fibers exhibit high strain at failure and very high mechanical strength [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Review of Spider Silk Applications in Biomedical and Tissue Engineering

Branković,

Zivic,

Grujovic

et al. 2024

Biomimetics

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This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems. Silk is one of the toughest natural materials, with high strain at failure and mechanical strength. Novel biomaterials with silk fibroin can mimic the tissue structure and promote regeneration and new tissue growth. Silk proteins are important in designing tissue-on-chip or organ-on-chip technologies and micro devices for the precise engineering of artificial tissues and organs, disease modeling, and the further selection of adequate medical treatments. Recent research indicates that silk (films, hydrogels, capsules, or liposomes coated with silk proteins) has the potential to provide controlled drug release at the target destination. However, even with clear advantages, there are still challenges that need further research, including clinical trials.

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Section: Spider Silk Structuresmentioning

confidence: 99%