Identification, characterization, and developmental profile of a high molecular weight, juvenile hormone‐binding protein in the hemolymph of the migratory grasshopper, <i>Melanoplus sanguinipes</i>

Ismail, Sheikh M.; Gillott, Cedric

doi:10.1002/arch.940290408

Cited by 20 publications

(14 citation statements)

References 45 publications

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“…This JHBP is a minor protein in the hemolymph (1-2% of total hemolymph protein), but the concentration of binding sites in the hemolymph is high (11-26 pM), due to its hexameric structure. A JHBP with similar characteristics was recently described for the grasshopper, Melanoplus sanguinipes (Ismail and Gillott, 1995). These two independent studies suggest that orthopterans have a distinct class of JHIII-specific binding protein.…”

Section: Juvenile Hormone Binding Proteinssupporting

confidence: 71%

Regulation of JH titers: The relevance of degradative enzymes and binding proteins

Kort

Granger

1996

Arch. Insect Biochem. Physiol.

112

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Juvenile hormones play a crucial role in development, metamorphosis, and reproduction of insects. This mini‐review discusses the nature of the juvenile hormones identified in insects and their changes in concentration in the hemolymph during development and reproduction. The hemolymph titer is largely determined by the rate at which juvenile hormones are synthesized and released by the corpora allata, but other factors are also involved in titer regulation, such as the affinity and concentration of juvenile hormone binding proteins in the hemolymph and the rate of juvenile hormone degradation in hemolymph and tissues. Juvenile hormone specific esterases occur in hemolymph and tissues, whereas epoxide hydrolases, which may degrade the hormone, are exclusively tissue bound. The activities of these degradative enzymes and the concentration of binding proteins change during the insect life cycle and these changes are related to fluctuations in hormone titer. However, we are still a long way from understanding the subtle interactions between these components in regulation of juvenile hormone titers. In particular, our knowledge is hampered by lack of information about the types, concentrations, and affinities of intracellular juvenile hormone receptors. © 1996 Wiley‐Liss, Inc.

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Section: Juvenile Hormone Binding Proteinssupporting

confidence: 71%

Regulation of JH titers: The relevance of degradative enzymes and binding proteins

Kort

Granger

1996

Arch. Insect Biochem. Physiol.

112

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“…Manual annotation showed that these PPO-like sequences consist of three conserved domains, Hemocyanin_N, Hemocyanin_C and the copper-containing Hemocyanin_M. But NCBI blast results suggested that they were more homologous to hexamerin storage protein, which are hemocyanin-derived proteins with functions in amino acid storage 55 56 , juvenile hormone (JH) binding 57 and in reproduction and metamorphosis 58 . Functional analysis needs to be performed to identify the actual roles of these proteins in P. xylostella .…”

Section: Resultsmentioning

confidence: 99%

Genome-wide characterization and expression profiling of immune genes in the diamondback moth, Plutella xylostella (L.)

Xia

Xue

et al. 2015

Sci Rep

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The diamondback moth, Plutella xylostella (L.), is a destructive pest that attacks cruciferous crops worldwide. Immune responses are important for interactions between insects and pathogens and information on these underpins the development of strategies for biocontrol-based pest management. Little, however, is known about immune genes and their regulation patterns in P. xylostella. A total of 149 immune-related genes in 20 gene families were identified through comparison of P. xylostella genome with the genomes of other insects. Complete and conserved Toll, IMD and JAK-STAT signaling pathways were found in P. xylostella. Genes involved in pathogen recognition were expanded and more diversified than genes associated with intracellular signal transduction. Gene expression profiles showed that the IMD pathway may regulate expression of antimicrobial peptide (AMP) genes in the midgut, and be related to an observed down-regulation of AMPs in experimental lines of insecticide-resistant P. xylostella. A bacterial feeding study demonstrated that P. xylostella could activate different AMPs in response to bacterial infection. This study has established a framework of comprehensive expression profiles that highlight cues for immune regulation in a major pest. Our work provides a foundation for further studies on the functions of P. xylostella immune genes and mechanisms of innate immunity.

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“…In male M. sanguinipes, JH I11 is the sole identifiable product of the corpora allata (Couche et al, 1985). As in other insects, JH is transported through the hemolymph to its site of action bound to a hexameric, 480 kDa protein (Ismail and Gillott, 1995b). On reaching the long hyaline tubule, JH becomes associated with a 40 kDa, high affinity, cytosolic binding protein (Ismail and Gillott, 1994).…”

Section: Endocrine Control Of Mag Secretory Activitymentioning

confidence: 99%

Male insect accessory glands: Functions and control of secretory activity

Gillott

1996

Invertebrate Reproduction & Development

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Paralleling the diversity of the class Insecta, the male accessory glands (MAG) exhibit a wide range of form, and their secretion serves a variety of finctions, including spermatophore and mating plug formation, sperm activation, provision of nutrients to females, and, through production of fecundity-enhancing andlor receptivity-inhibiting substances, modification of female reproductive behavior. In most insects, juvenile hormone (JH) is important in the regulation of MAG secretory activity; specifically, JH controls the production of particular proteins in the secretion. However, the production of some proteins appears not to be influenced by JH; rather, their synthesis is regulated by ecdysteroids. During sexual maturation, JH and ecdysteroids seem to interact to bring about a specified temporal sequence of protein synthesis in the MAG.

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Identification, characterization, and developmental profile of a high molecular weight, juvenile hormone‐binding protein in the hemolymph of the migratory grasshopper, Melanoplus sanguinipes

Cited by 20 publications

References 45 publications

Regulation of JH titers: The relevance of degradative enzymes and binding proteins

Regulation of JH titers: The relevance of degradative enzymes and binding proteins

Genome-wide characterization and expression profiling of immune genes in the diamondback moth, Plutella xylostella (L.)

Male insect accessory glands: Functions and control of secretory activity

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