Identification of a 55 kDa <i>Haemonchus contortus</i> excretory/secretory glycoprotein as a neutrophil inhibitory factor

Anbu, K. A.; Joshi, Pallavi

doi:10.1111/j.1365-3024.2007.00995.x

Cited by 35 publications

(36 citation statements)

References 36 publications

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“…Neutrophil inhibitory factor (NIF) is a glycoprotein from the ES of the canine hookworm A. caninum (130). NIF selectively binds the CD11b/CD18 complex, a pattern recognition receptor found on polymorphonuclear leukocytes.…”

Section: Immune Modulating Excretory Secretory Productsmentioning

confidence: 99%

Helminth Immunomodulation in Autoimmune Disease

et al. 2017

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Helminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating “talents” of helminths to treat inflammatory human diseases is receiving intensive interest. Here, we review therapies using live parasitic worms, worm secretions, and worm-derived synthetic molecules to treat autoimmune disease. We review helminth therapy in both mouse models and clinical trials and discuss what is known on mechanisms of action. We also highlight current progress in characterizing promising new immunomodulatory molecules found in excretory/secretory products of helminths and their potential use as immunotherapies for acute and chronic inflammatory diseases.

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Section: Immune Modulating Excretory Secretory Productsmentioning

confidence: 99%

Helminth Immunomodulation in Autoimmune Disease

et al. 2017

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“…It appears that helminths are no less able to also modulate these innate populations. For example, both the dog hookworm Ancylostoma caninum and the livestock parasite Haemonchus contortus export factors which inhibit neutrophil activation 101,102. Moreover, human hookworm products also cleave eotaxin, suppressing recruitment of eosinophils 103.…”

Section: Early and Late In The Immune Responsementioning

confidence: 99%

Helminths in the hygiene hypothesis: sooner or later?

Maizels

McSorley

Smyth

2014

Clinical and Experimental Immunology

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SummaryThere is increasing recognition that exposures to infectious agents evoke fundamental effects on the development and behaviour of the immune system. Moreover, where infections (especially parasitic infections) have declined, immune responses appear to be increasingly prone to hyperactivity. For example, epidemiological studies of parasite-endemic areas indicate that prenatal or early-life experience of infections can imprint an individual’s immunological reactivity. However, the ability of helminths to dampen pathology in established inflammatory diseases implies that they can have therapeutic effects even if the immune system has developed in a low-infection setting. With recent investigations of how parasites are able to modulate host immune pathology at the level of individual parasite molecules and host cell populations, we are now able to dissect the nature of the host–parasite interaction at both the initiation and recall phases of the immune response. Thus the question remains – is the influence of parasites on immunity one that acts primarily in early life, and at initiation of the immune response, or in adulthood and when recall responses occur? In short, parasite immunosuppression – sooner or later?

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“…ESPs contain various proteins and are capable to induce the depression or instigation of the host immune response and are related to the pathogenesis of the parasites [5–7]. Binding to the host cell is a prerequisite for ESP function [3, 8–11]. Some ESP molecules react to the molecules on the surface of the host cell to form receptor-ligand complexes, similar to many other receptor-ligand systems.…”

Section: Introductionmentioning

confidence: 99%

“…A 55kDa secretory glycoprotein was identified with the ability to inhibit host neutrophils [8]. The purified 66-kDa adult H. contortus excretory/secretory (E/S) antigen was confirmed to suppress monocyte function in vitro by decreasing the production of hydrogen peroxide and nitric oxide in the culture medium of the cells [3].…”

Section: Introductionmentioning

confidence: 99%

Haemonchus contortusexcretory and secretory proteins (HcESPs) suppress functions of goat PBMCsin vitro

Gadahi

Ehsan

et al. 2016

Oncotarget

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Excretory and secretory products (ESPs) of nematode contain various proteins which are capable of inducing the instigation or depression of the host immune response and are involved in the pathogenesis of the worms. In the present study, Haemonchus contortus excretory and secretory products (HcESPs) were collected from the adult worms. Binding of HcESPs to goat peripheral blood mononuclear cells (PBMCs) was confirmed by immune-fluorescence assay. Effects of the HcESPs on cytokine production, cell proliferation, cell migration and nitric oxide (NO) production of PBMCs were checked by co-incubation of HcESPs with goat PBMCs. The results indicated that the production of IL-4 and IFN-γ were significantly decreased by HcESPs in dose dependent manner. On the contrary, the production of IL-10 and IL-17 were increased. Cell migration was significantly enhanced by HcESPs, whereas, HcESPs treatment significantly suppressed the cell proliferation and NO production. These results indicated that the HcESPs played important suppressive regulatory roles on PBMCs and provided highlights to the understanding of the host-parasite interactions.

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Identification of a 55 kDa Haemonchus contortus excretory/secretory glycoprotein as a neutrophil inhibitory factor

Cited by 35 publications

References 36 publications

Helminth Immunomodulation in Autoimmune Disease

Helminth Immunomodulation in Autoimmune Disease

Helminths in the hygiene hypothesis: sooner or later?

Haemonchus contortusexcretory and secretory proteins (HcESPs) suppress functions of goat PBMCsin vitro

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