Identification of a class of
            <i>Saccharomyces cerevisiae</i>
            mutants defective in fatty acid repression of gene transcription and analysis of the
            <i>frm2</i>
            Gene

McHale, Michael W.; Kroening, K. Dubear; Bernlohr, David A.

doi:10.1002/(sici)1097-0061(19960330)12:4<319::aid-yea914>3.0.co;2-#

Cited by 23 publications

(4 citation statements)

References 38 publications

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“…However, none of the nfo1 to nfo4 mutations were suppressed by single or multicopies of the RGR1 gene (our unpublished results). Neither nfo3‐1 nor nfo4‐1 mutations were suppressed by either FRM2 [18], ROX1 , TUP1 or SSN6 [21, 22, 50] gene (our unpublished results), suggesting that NFO3 and NFO4 are likely unidentified genes encoding global repressors.…”

Section: Resultsmentioning

confidence: 87%

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Isolation and characterization of mutations affecting expression of the Δ9‐ fatty acid desaturase gene, OLE1, in Saccharomyces cerevisiae

et al. 1997

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Section: Resultsmentioning

confidence: 87%

“…ACBP , and FAA1 and FAA4 genes have been involved in activation and UFA‐mediated repression of OLE1 gene expression [13]. McHale et al isolated the frm2 mutant which is defective in UFA‐mediated repression of OLE1 gene expression and suggested that the FRM2 protein is involved in the fatty acid signal transduction pathway [18].…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of mutations affecting expression of the Δ9‐ fatty acid desaturase gene, OLE1, in Saccharomyces cerevisiae

et al. 1997

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“…NR-like BluB found in R. capsulatus, Sinorhizobium meliloti, and Selenomonas ruminantium is found to be involved in the biosynthetic pathway of cobalamin, which is in turn, a cofactor in several enzymatic reactions [47]. The NR-like Frm2p of S. cerevisiae has been observed to be involved in the lipidsignaling pathway [48]. The NR FRaseI in Vibrio fischeri can produce reduced flavin needed in the luciferase reaction involving in the bioluminescence process [49][50][51].…”

Section: Physiological Functions Of Nitroreductasesmentioning

confidence: 99%

Microbial nitroreductases: A versatile tool for biomedical and environmental applications

Boddu

Perumal

Divakar³

2020

Biotechnology and Applied Biochemistry

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Nitroreductases, enzymes found mostly in bacteria and also in few eukaryotes, use nicotinamide adenine dinucleotide (NADH) or nicotinamide adenine dinucleotide phosphate (NADPH) as a cofactor for their activity and metabolize an enormous list of a diverse nitro group-containing compounds. Nitroreductases that are capable of metabolizing nitroaromatic and nitro heterocyclic compounds have drawn great attention in recent years owing to their biotechnological, biomedical, environmental, and human impact. These enzymes attracted medicinal chemists and pharmacologists because of their prodrug selectivity for activation/reduction of nitro compounds that wipe out pathogens/cancer cells, leaving the host/normal cells unharmed. It is applied in diverse fields of study like prodrug activation in treating cancer and leishmaniasis, designing fluorescent probes for hypoxia detection, cell imaging, ablation of specific cell types, biodegradation of nitro-pollutants, and interpretation of mutagenicity of nitro compounds. Keeping in view the immense prospects of these enzymes and a large number of research contributions in this area, the present review encompasses the enzymatic reaction mechanism, their role in antibiotic resistance, hypoxia sensing, cell imaging, cancer therapy, reduction of recalcitrant nitro chemicals, enzyme variants, and their specificity to substrates, reaction products, and their applications.

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“…The expression of the gene encoding this protein is only dependent on Yap2 in the presence of cadmium. Frm2 shares high identity with type 4 nitrore-ductases, shown to be involved in the fatty acid signalling pathway and required for unsaturated fatty acid control of the stearoyl-CoA desaturase gene ( OLE1 ) expression [64]. FRM2 was also identified in a screen for mutants defective in OLE1 repression by unsaturated fatty acids, and the fact that the frm2 mutant is sensitive to arachidonic acid led to the hypothesis that FRM2 participates in lipid metabolism [62].…”

Section: Yap2/cad1 Involvement In Cadmium and Oxidatve Stressmentioning

confidence: 99%

Yeast AP-1 like transcription factors (Yap) and stress response: a current overview

Rodrigues-Pousada¹,

Devaux²,

Caetano³

et al. 2019

Microb Cell

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Yeast adaptation to stress has been extensively studied. It involves large reprogramming of genome expression operated by many, more or less specific, transcription factors. Here, we review our current knowledge on the function of the eight Yap transcription factors (Yap1 to Yap8) in Saccharomyces cerevisiae , which were shown to be involved in various stress responses. More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds. Yap3 and Yap7 seem to be involved in hydroquinone and nitrosative stresses, respectively. The data presented in this article illustrate how much knowledge on the function of these Yap transcription factors is advanced. The evolution of the Yap family and its roles in various pathogenic and non-pathogenic fungal species is discussed in the last section.

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Identification of a class of Saccharomyces cerevisiae mutants defective in fatty acid repression of gene transcription and analysis of the frm2 Gene

Cited by 23 publications

References 38 publications

Isolation and characterization of mutations affecting expression of the Δ9‐ fatty acid desaturase gene, OLE1, in Saccharomyces cerevisiae

Isolation and characterization of mutations affecting expression of the Δ9‐ fatty acid desaturase gene, OLE1, in Saccharomyces cerevisiae

Microbial nitroreductases: A versatile tool for biomedical and environmental applications

Yeast AP-1 like transcription factors (Yap) and stress response: a current overview

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