Identification of a fish-specific NOD-like receptor subfamily C (NLRC) gene from common carp (Cyprinus carpio L.): Characterization, ontogeny and expression analysis in response to immune stimulation

Li, Ting; Shan, Shijuan; Wang, Lei; Gao, Yang; Zhu, Jianping

doi:10.1016/j.fsi.2018.08.045

Cited by 32 publications

(19 citation statements)

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“…Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a group of cytoplasmic pattern recognition receptors (PRRs), which are responsible for detecting various pathogens and generating innate immune responses. In fish, three distinct subfamilies of NLRs have been identified and characterized: NLR-A, NLR-B, and fish-specific NLR-C [52]. Expression of NLR-C subfamily (NLRCs) has been reported in many different teleost fish species such as zebrafish [53], Japanese flounder [54] and turbot [55].…”

Section: Discussionmentioning

confidence: 99%

“…Expression of NLR-C subfamily (NLRCs) has been reported in many different teleost fish species such as zebrafish [53], Japanese flounder [54] and turbot [55]. These receptors are activated by a variety of bacterial pathogens or microbial ligands, including lipopolysaccharides (LPS), peptidoglycans (PGN) and polyinosinic-polycytidylic acid (Poly (I:C)), suggesting their participation in the fish innate immune response [52]. The other signaling pathway with greater annotation was related to Chemokines, small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response.…”

Section: Discussionmentioning

confidence: 99%

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De novo assembly and characterization of the liver transcriptome of Mugil incilis (lisa) using next generation sequencing

Bertel-Sevilla

Alzate-Restrepo

Olívero-Verbel

2019

Preprint

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Background Mugil incilis (lisa) is an important commercial fish species in many countries, living along the coasts of the western Atlantic Ocean. It has been used as a model organism for environmental monitoring and ecotoxicological investigations. Nevertheless, available genomic and transcriptomic information for this organism is extremely deficient. The aim of this study was to characterize M. incilis hepatic transcriptome using Illumina paired-end sequencing. Results A total of 32.082.124 RNA-Seq read pairs were generated utilizing the HiSeq platform and subsequently cleaned and assembled into 93.947 contigs (with N50 = 2.019 bp). The analysis of species distribution revealed that M. incilis contigs had the highest number of hits to Stegastes partitus (36.6%). Using a sequence similarity search against the public databases GO and KEGG, a total of 71.271 and 16.974 contigs were annotated, respectively. KEGG showed genes related to environmental information, metabolism and organismal system pathways were highly annotated. Complete or partial coding DNA sequences for several candidate genes associated with stress responses/detoxification of xenobiotics, as well as housekeeping genes, were employed to design primers that were successfully tested and validated by RT-qPCR. Conclusions This study presents the first transcriptome resources for Mugil incilis and provides basic information for the development of genomic tools, such as the identification of RNA markers, useful to analyze environmental impacts on this fish Caribbean species.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

De novo assembly and characterization of the liver transcriptome of Mugil incilis (lisa) using next generation sequencing

Bertel-Sevilla

Alzate-Restrepo

Olívero-Verbel

2019

Preprint

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“…These PRRs can recognize the highly conserved molecular structures on the surfaces of invading pathogenic micro‐organisms, thereby activating receptor‐associated signalling pathways. There are many types of PRRs, which can be divided into multiple protein families based on differences in ligand recognition and functions: (a) peptidoglycan recognition proteins (PGRPs) 4‐6 ; (b) thioester‐containing proteins (TEPs) 7‐9 ; (c) gram‐negative bacteria‐binding proteins (GNBPs) 3,10 ; (d) scavenger receptors (SCRs) 11‐13 ; (e) lectins 14‐16 ; (f) galectins (GALEs) 17‐19 ; (g) Toll‐like receptors (TLRs) 20‐26 ; (h) retinoic acid‐inducible gene (RIG)‐like receptors (RIG‐like) 27‐29 and (i) haemoglobin 30‐32 and nucleotide‐binding oligomerization domain (NOD)‐like receptors 29,33‐35 . In general, the process by which a host cell recognizes a micro‐organism is rather complex and requires multiple opsonin receptors or non‐opsonin receptors to kill the micro‐organism 36‐38 …”

Section: Introductionmentioning

confidence: 99%

A comparative review of intelectins

Chen

Gao

2020

Scand J Immunol

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Intelectin (ITLN) is a new type of glycan‐binding lectin. It has been demonstrated to agglutinate bacteria probably due to its carbohydrate‐binding capacity, suggesting its role in an innate immune response. It is involved not only in many physiological processes but also in some human diseases such as asthma, heart disease, inflammatory bowel disease, chronic obstructive pulmonary disease and cancer. Up to now, intelectin orthologs have been identified in placozoans, urochordatas, cephalochordates and several vertebrates, such as cyclostomata, fish, amphibians and mammals. Although the sequences of intelectins in different species are conserved, their expression patterns, quaternary structures and functions differ considerably among and within species. We summarize the evolution of the intelectin gene family, the tissue distribution, structure and functions of intelectins. We conclude that intelectin plays a role in innate immune response and there are still potential functions of intelectin awaiting discovery.

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“…Viruses are noncellular life forms composed of proteins and a DNA or RNA genome wrapped in a protective protein coat. As parasites, viruses infect an organism and self‐replicate using host cellular components . The first step in this process is invasion of target cells in the host tissue, which typically comprises a layer of epithelial cells connected via intercellular junctions.…”

Section: Introductionmentioning

confidence: 99%

“…As parasites, viruses infect an organism and selfreplicate using host cellular components. [9][10][11] The first step in this process is invasion of target cells in the host tissue, which typically comprises a layer of epithelial cells connected via intercellular junctions. These junctions allow the transmission of information between cells and the surrounding environment and serve as a protective barrier against noxious stimuli.…”

Section: Introductionmentioning

confidence: 99%

Alteration of cell junctions during viral infection

2020

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Cell junctions serve as a protective barrier for cells and provide an important channel for information transmission between cells and the surrounding environment. Viruses are parasites that invade and commandeer components of host cells in order to survive and replicate, and they have evolved various mechanisms to alter cell junctions to facilitate viral infection. In this review, we examined the current state of knowledge on the action of viruses on host cell junctions. The existing evidence suggests that targeting the molecules involved in the virus‐cell junction interaction can prevent the spread of viral diseases.

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Identification of a fish-specific NOD-like receptor subfamily C (NLRC) gene from common carp (Cyprinus carpio L.): Characterization, ontogeny and expression analysis in response to immune stimulation

Cited by 32 publications

References 58 publications

De novo assembly and characterization of the liver transcriptome of Mugil incilis (lisa) using next generation sequencing

De novo assembly and characterization of the liver transcriptome of Mugil incilis (lisa) using next generation sequencing

A comparative review of intelectins

Alteration of cell junctions during viral infection

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