2021
DOI: 10.3389/fcell.2020.604627
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Identification of a Gene Signature for Renal Cell Carcinoma–Associated Fibroblasts Mediating Cancer Progression and Affecting Prognosis

Abstract: Background: Cancer-associated fibroblasts (CAFs) are mainly involved in cancer progression and treatment failure. However, the specific signature of CAFs and their related clinicopathological parameters in renal cell carcinoma (RCC) remain unclear. Here, methods to recognize gene signatures were employed to roughly assess the infiltration of CAFs in RCC, based on the data from The Cancer Genome Atlas (TCGA). Weighted Gene Coexpression Network Analysis (WGCNA) was used to cluster transcriptomes and correlate wi… Show more

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Cited by 38 publications
(30 citation statements)
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“…This is a novel method to explore the relationship between numerous genes and clinical phenotypes. WGCNA has been applied to identify CAF markers, such as in gastric cancer (13), bladder cancer (14), and renal cell carcinoma (15). However, to date, CAFs have not been analyzed by WGCNA in large-sample multicenter OC cohorts.…”
Section: Introductionmentioning
confidence: 99%
“…This is a novel method to explore the relationship between numerous genes and clinical phenotypes. WGCNA has been applied to identify CAF markers, such as in gastric cancer (13), bladder cancer (14), and renal cell carcinoma (15). However, to date, CAFs have not been analyzed by WGCNA in large-sample multicenter OC cohorts.…”
Section: Introductionmentioning
confidence: 99%
“…We first calculated the CAFs score for each patient based on 56 CAFs markers reported in literature through the GSVA algorithm. Subsequently, WGCNA was applied to construct gene co-expression networks, which has the potential to identify CAFs-related genes ( 59 ),and the green module from networks was of the highest correlation with the CAFs score. By intersecting green module genes and the DEGs, we obtained 27 response-associated CDEGs for anti-PD-1 therapy.…”
Section: Discussionmentioning
confidence: 99%
“…The EPIC (http://epic.gfellerlab.org/) tool was used to estimate the fraction of CAFs and explore the changes in the matrix components of PeCa and normal tissues (internal set) (31). EPIC establishes reference gene expression profiles for major tumorinvasive immune cell types (CD4+ T, CD8+ T, B, natural killer, and macrophages) and further deduces the reference spectra of CAFs and endothelial cells (32).…”
Section: Cancer-associated Fibroblast Scorementioning
confidence: 99%