Identification of a glucocorticoid response element in the human transforming growth factor beta 1 gene promoter

AP-1 overexpression impairs corticosteroid inhibition of collagen production by fibroblasts isolated from asthmatic subjects

“…We found that TGF-␤ induced procollagen mRNA expression, protein levels, and promoter activity from NBF and ABF but cannot be antagonized by Dex treatment. A GR response element is present in the TGF-␤ gene promoter and is thus susceptible to CS treatment (31,35). We found that the expression of TGF-␤ was reduced by CS in normal cells but not in cells from asthmatics.…”

Plasma transforming growth factor-ß1 level in inflammatory bowel disease

“…It is known that plasma TGF-ß1 levels are affected by steroid use, and there are also studies implying that the plasma level of TGF-ß1 is affected by sulfasalazine and other anti-inflammatory drugs (22,23). For this reason, the patients included in our study were those who for various reasons including patient noncompliance, economic factors or social security problems had not received any kind of treatment at all.…”

Serum IL-17 level predicts inflammatory activity in patients with autoimmune hepatitis

“…Moreover, such medications inhibit TGF--β1 activation by weakening the protein binding activating the cytokine with its membrane receptor. 26 These observations indicate that by blocking TGF -β1 function while inhibiting the inflammatory cascade this drug class exerts the antifibrotic effect in patients with AIH.…”