Identification of a New Group of Bovine Viral Diarrhea Virus Strains Associated with Severe Outbreaks and High Mortalities

Pellerin, Charles; Hurk, Jan van den; Lecomte, Jacqueline; Tijssen, Peter

doi:10.1006/viro.1994.1483

Cited by 450 publications

(319 citation statements)

References 0 publications

Supporting

Mentioning

275

Contrasting

Unclassified

Order By: Relevance

“…More recently, severe acute outbreaks of BVDV-associated disease in young and adult cattle have been documented in Northeastern United States [21] and in the provinces of Québec [13,22] and Ontario [7] in Canada. In general, the disease was characterized by thrombocytopenia, leukopenia, fever, hemorrhages, diarrhea and death, and was attributed to ncp BVDV isolates.…”

Section: Introductionmentioning

confidence: 99%

“…In general, the disease was characterized by thrombocytopenia, leukopenia, fever, hemorrhages, diarrhea and death, and was attributed to ncp BVDV isolates. These isolates, on the basis of sequence comparison in the 5' untranslated region of the viral genome and antigenic analysis with panels of monoclonal antibodies, were determined to be BVDVs type 2 isolates [7,22,26], as opposed to the BVDV type 1 isolates.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical response and immunomodulation following experimental challenge of calves with type 2 noncytopathogenic bovine viral diarrhea virus

et al. 2000

View full text Add to dashboard Cite

-Eight calves between 16 and 18 weeks of age that were seronegative to bovine viral diarrhea virus (BVDV), bovine leucosis virus and bovine immunodeficiency-like virus were infected (day 0) intranasally with the type 2 noncytopathogenic Canadian 24515 field isolate of BVDV in order to evaluate the effect of BVDV infection on certain clinical, hematological and immunological parameters. All virus-exposed animals developed fever and showed a significant (P < 0.05, 0.01 or 0.001) drop in the number of circulating leucocytes (neutrophils, lymphocytes and monocytes) by day 3 or 5 post-exposure (PE), which continued to the end of the experiment at day 12 PE. BVDV was consistently isolated from the peripheral blood buffy coat cells from day 5 PE, and also from selected tissues (spleen, thymus, mesenteric and submaxillary lymph nodes, small intestine, lungs and thyroid gland) that were collected at the time of euthanasia of the animals at day 12 PE. Diminished significant (P < 0.05) percentages of peripheral blood mononuclear cells (PBMCs) expressing at their surface either B7 and MHC II molecules were observed in virus-exposed calves at days 7, 10 and/or 12 PE, when compared to virus-nonexposed control calves (n = 5). However, no changes in the percentages of PBMCs expressing either B4 or MHC I molecules were observed throughout the experiment. Finally, a significant (P < 0.05 or 0.01) enhanced phagocytic capability of the PBMCs, as analyzed by flow cytometry, was observed in virus-exposed animals at days 3, 5, 7, 10 and 12 PE, when compared to control calves. These results demonstrated the virulence of the 24515 isolate of BVDV in 4 to 4.5 month-old calves, and suggest that type 2 BVDV infection in calves is associated with dysregulation of certain immunological functions. bovine viral diarrhea virus type 2 / clinical response / immunomodulation Vet. Res. 31 (2000) 215-227 215

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical response and immunomodulation following experimental challenge of calves with type 2 noncytopathogenic bovine viral diarrhea virus

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Furthermore, the inability to characterise subgroups with BVDV-1 shown by Pellerin et al, (1994), suggests that although nucleotide variation was observed in the nucleotide sequences of this study it is unlikely that there is significance antigenic variation with these viruses.…”

Section: Nucleotide Sequence Analysismentioning

confidence: 63%

“…However, characterisation of subgroups within the two genotypes was not observed (Pellerin et al 1994). This indicates that nucleotide sequence analysis provides greater clarification when characterising BVDV strains.…”

Section: Nucleotide Sequence Analysismentioning

confidence: 93%

“…Therefore successful vaccination strategies must provide naïve animals with adequate protection against acute infection, as well as providing protection to susceptible foetuses in order to prevent the development of a PI calf (Fulton et al 2003). BVDV-1 and BVDV-2 stains also identified a significant difference in reactivity which questions the efficacy of BVDV-1 vaccines to provide adequate protection to animals challenged with a BVDV-2 virus (Pellerin et al 1994). This could have serious implications for Irish herds as both Bovilis and Bovidec only contain a BVDV-1a strain while Rispoval contains a BVDV-1a strain and an unknown strain (Vilcek et al 1999;Fulton et al 2003;this study).…”

Section: Genotyping and Vaccine Efficacymentioning

confidence: 99%

See 1 more Smart Citation

Genetic typing of bovine viral diarrhoea virus in cattle on Irish farms

O’Brien

Garvey

Walsh

et al. 2017

Research in Veterinary Science

View full text Add to dashboard Cite

The genotype and subgenotype was established for 325 field viruses and one commercial vaccine viral strain based on the analysis of at least one genomic region. BVDV-1a was the prominent subgenotype (n=317) with BVDV-1b (n=6), BVDV-1d (n=1) and BVDV-1e (n=1) also observed. A number of nucleotide sequence alignments and phylogenetic trees were constructed to represent the relationship between Irish field viruses and reference strains representative of all known BVDV genotypes and subgenotypes. Evidence of both herd specific clustering and circulation of multiple strains within herds was observed; however no evidence of county specific clustering was observed. A number of completely conserved nucleotide regions were observed and the 5'UTR was found to be more conserved than the N pro fragment analysed. The results of this study provide a detailed and comprehensive insight into the genetic diversity of BVDV in circulation within Irish cattle herds and will act as a baseline reference for future BVDV genotyping studies.

show abstract

Introduction and History

Deregt¹

2005

Bovine Viral Diarrhea Virus

View full text Add to dashboard Cite

Identification of a New Group of Bovine Viral Diarrhea Virus Strains Associated with Severe Outbreaks and High Mortalities

Cited by 450 publications

References 0 publications

Clinical response and immunomodulation following experimental challenge of calves with type 2 noncytopathogenic bovine viral diarrhea virus

Clinical response and immunomodulation following experimental challenge of calves with type 2 noncytopathogenic bovine viral diarrhea virus

Genetic typing of bovine viral diarrhoea virus in cattle on Irish farms

Introduction and History

Contact Info

Product

Resources

About