Identification of a New HIV-1 Circulating Recombinant Form
CRF112_01B Strain in Baoding City, Hebei Province, China

In recent years, many new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) of human immunodeficiency virus type one (HIV-1) have been discovered among men who have sex with men (MSM) in China. In this study, we report two HIV-1 URFs (BDL154 and BDL161) identified in the MSM population in Hebei Province, China. The phylogenetic tree and recombination analysis based on the near-full-length genome (NFLG) sequences showed that BDL154 was a recombination form originated from CRF01_AE and subtype B, whereas BDL161 consisted of subtypes C ,B and CRF01_AE. BDL154 and BDL161 contained three and eight fragments, respectively. The analysis of recombination breakpoints showed that the recombination pattern of BDL154 sequence was the insertion of one B gene fragment into the backbone of CRF01_AE, whereas the recombination pattern of BDL161 sequence was the insertion of two CRF01_AE and two B gene fragments into the backbone of subtype C. The emergence of CRF01_AE/B and C/B/CRF01_AE suggests that we should continuously monitor the recombinant forms of HIV-1 among MSM population, which can provide the data for the controlling of HIV-1 epidemic.

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Identification of two near-identical novel HIV-1 unique recombinant forms (CRF01_AE/B) among men who have sex with men in baoding, hebei, China

Zhang

Chen²,

Meng³

et al. 2023

Front. Genet.

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Men who have sex with men (MSM) are the most frequent infection route of the human immunodeficiency virus (HIV) in Baoding, China, creating chances for the occurrence of unique recombinant forms (URFs) of the virus, i.e., recombination of different subtypes caused by co-circulation of multiple subtypes. In this report, two near-identical URFs (BDD002A and BDD069A) isolated from MSM in Baoding were identified. Phylogenetic tree analysis based on nearly full-length genomes (NFLGs) revealed that the two URFs formed a distinct monophyletic cluster with a bootstrap value of 100%. Recombinant breakpoints analysis identified that the NFLGs of BDD002A and BDD069A were both composed of CRF01_AE and subtype B, with six subtype B mosaic segments inserted into the CRF01_AE backbone. The CRF01_AE segments of the URFs clustered closely with the CRF01_AE reference sequences, and the B subregions clustered with the B reference sequences. The recombinant breakpoints of the two URFs were almost identical. These results suggest that effective interventions are urgently needed to prevent the formation of complex HIV-1 recombinant forms in Baoding, China.

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Identification of a New HIV-1 Circulating Recombinant Form CRF112_01B Strain in Baoding City, Hebei Province, China

Cited by 3 publications

References 48 publications

Genomic Characterization of a Novel HIV-1 Second-Generation Recombinant (CRF01_AE/CRF07_BC) Identified from a Men Who Have Sex with Men (MSM) Patient in Hebei, China

Genomic Characterization of a Novel HIV-1 Second-Generation Recombinant (CRF01_AE/CRF07_BC) Identified from a Men Who Have Sex with Men (MSM) Patient in Hebei, China

Characterization of two novel HIV-1 recombinant forms (CRF01_AE/B and C/B/CRF01_AE) Among Men Who Have Sex with Men in Hebei Province, China

Identification of two near-identical novel HIV-1 unique recombinant forms (CRF01_AE/B) among men who have sex with men in baoding, hebei, China

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