Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production

Han, Ah Reum; Min, Hye Young; Nam, Joo Won; Lee, Na Youn; Wiryawan, Adam; Suprapto, Wahyu; Lee, Sang Kook; Lee, Kang Ro; Seo, Eun Kyoung

doi:10.1248/cpb.56.1314

Cited by 40 publications

(31 citation statements)

References 17 publications

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“…When evaluated in vitro , they showed satisfactory action against inflammation induced by LPS in mouse macrophage RAW 264.7 cell lines. [85] Similarly, luteolin is a newer flavone which occurs indigenously in several plants and helps a lot for its antioxidant, antinflammatory and antiallergic functions as compared to other flavonoids. [86]…”

Section: Specific Phytoconstituents With Promising Value Of Anti-inflmentioning

confidence: 99%

Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives

et al. 2011

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Many synthetic drugs reported to be used for the treatment of inflammatory disorders are of least interest now a days due to their potential side effects and serious adverse effects and as they are found to be highly unsafe for human assistance. Since the last few decades, herbal drugs have regained their popularity in treatment against several human ailments. Herbals containing anti-inflammatory activity (AIA) are topics of immense interest due to the absence of several problems in them, which are associated with synthetic preparations. The primary objective of this review is to provide a deep overview of the recently explored anti-inflammatory agents belonging to various classes of phytoconstituents like alkaloids, glycosides, terpenoids, steroids, polyphenolic compounds, and also the compounds isolated from plants of marine origin, algae and fungi. Also, it enlists a distended view on potential interactions between herbals and synthetic preparations, related adverse effects and clinical trials done on herbals for exploring their AIA. The basic aim of this review is to give updated knowledge regarding plants which will be valuable for the scientists working in the field of anti-inflammatory natural chemistry.

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Section: Specific Phytoconstituents With Promising Value Of Anti-inflmentioning

confidence: 99%

Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives

et al. 2011

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“…Although naphthoquinones have also a toxicological potential, mainly due to their ability to induce oxidative stress [8], they can be good lead compounds for new anti-inflammatory drugs, as several previous studies evidence. Bisnaphthoquinones inhibit platelet aggregation [9], plumbagin inhibits cytokines release [10], shikonin derivatives inhibit cyclooxygenase-2 expression [11], mast cell degranulation [12] and iNOS (an inducible calcium-independent isoform of nitric oxide (NO) synthases) [13], interfering with NO production [14]. However more studies are needed to confirm a really beneficial property.…”

Section: Introductionmentioning

confidence: 99%

Is Nitric Oxide Decrease Observed with Naphthoquinones in LPS Stimulated RAW 264.7 Macrophages a Beneficial Property?

et al. 2011

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The search of new anti-inflammatory drugs has been a current preoccupation, due to the need of effective drugs, with less adverse reactions than those used nowadays. Several naphthoquinones (plumbagin, naphthazarin, juglone, menadione, diosquinone and 1,4-naphthoquinone), plus p-hydroquinone and p-benzoquinone were evaluated for their ability to cause a reduction of nitric oxide (NO) production, when RAW 264.7 macrophages were stimulated with lipopolysaccharide (LPS). Dexamethasone was used as positive control. Among the tested compounds, diosquinone was the only one that caused a NO reduction with statistical importance and without cytotoxicity: an IC25 of 1.09±0.24 µM was found, with 38.25±6.50% (p<0.001) NO reduction at 1.5 µM. In order to elucidate if this NO decrease resulted from the interference of diosquinone with cellular defence mechanisms against LPS or to its conversion into peroxynitrite, by reaction with superoxide radical formed by naphthoquinones redox cycling, 3-nitrotyrosine and superoxide determination was also performed. None of these parameters showed significant changes relative to control. Furthermore, diosquinone caused a decrease in the pro-inflammatory cytokines: tumour necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6). Therefore, according to the results obtained, diosquinone, studied for its anti-inflammatory potential for the first time herein, has beneficial effects in inflammation control. This study enlightens the mechanisms of action of naphthoquinones in inflammatory models, by checking for the first time the contribution of oxidative stress generated by naphthoquinones to NO reduction.

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“…Some condensed tannins were reported to inhibit melanin formation in melanocytes such as proanthocyanidins and procyanidin [22][23][24]. E. palmifolia contains several naphthalenes, namely eleutherol, eleutherin, and isoeleuthrin [25], and some naphthalenes have been reported to act as inhibitors of lipopolysaccharideinduced nitric oxide production [26]. Moreover, the freeradical scavenging activity of this extract may be related in part to the inhibition of melanin formation.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of medicinal plants from Central Kalimantan for antimelanogenesis

Arung

Kusuma

Christy³

et al. 2009

J Nat Med

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In the course of searching for new materials to use as whitening agents, we screened 19 methanol extracts prepared from 14 medicinal plants from Central Kalimantan province, Indonesia. The screening methods used were the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, a tyrosinase inhibition assay, and a melanin formation inhibition assay using B16 melanoma cells. The extracts of Willughbeia coriacea (bark part of aerial root), Phyllanthus urinaria (root), Eleutherine palmifolia (bulb), Eusideroxylon zwageri (seed), Dendrophthoe petandra (aerial root), Passiflora foetida (stem), and Vitex pinnata (root) showed DPPH radical-scavenging activity of more than 70% at 100 microg/ml. The extracts of W. coriacea (bark part of aerial root), P. urinaria (root), and D. petandra (aerial root) showed tyrosinase inhibitory activity of more than 40% using L-tyrosine as a substrate at 500 microg/ml. The extracts of W. coriacea (bark part of aerial root) and D. petandra (aerial root) showed tyrosinase inhibitory activity of more than 40% using L-DOPA as a substrate at 500 microg/ml. The extracts of W. coriacea (bark part of aerial root, 200 microg/ml), Glochidion philippcum (aerial root, 200 and 300 microg/ml), E. palmifolia (bulb, 50 microg/ml), E. zwageri (seed, 100 microg/ml), D. petandra (aerial root, 200 microg/ml), Lansium domesticum (bark, 25 microg/ml), P. foetida (stem, fruit, 300 microg/ml), and Solanum torvum (root, 300 microg/ml) strongly inhibited the melanin production of B16 melanoma cells without significant cytotoxicity. These findings indicate that some medicinal plants from Central Kalimantan are potential ingredients for skin-whitening cosmetics if their safety can be confirmed.

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Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production

Cited by 40 publications

References 17 publications

Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives

Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives

Is Nitric Oxide Decrease Observed with Naphthoquinones in LPS Stimulated RAW 264.7 Macrophages a Beneficial Property?

Evaluation of medicinal plants from Central Kalimantan for antimelanogenesis

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