Identification of a Novel Ran Binding Protein 2 Related Gene (RANBP2L1) and Detection of a Gene Cluster on Human Chromosome 2q11–q12

Nothwang, Hans Gerd; Rensing, Christopher; Kübler, Matthias; Denich, Dagmar; Brandl, Birgit; Stubanus, Mike; Haaf, Thomas; Kurnit, David M.; Hildebrandt, Friedhelm

doi:10.1006/geno.1997.5119

Cited by 33 publications

(24 citation statements)

References 30 publications

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“…These domains in the structure of BS-63 gene suggest that it is related to components of NPC. A recent study [19] showed that RanBP2 related gene has 99% identity with BS-63 over 1913 bp. Also, both BS-63 and RanBP2 sequences were localized to 2 q11-q12 by FISH analysis, showing that they are probably the same entity.…”

Section: Discussionmentioning

confidence: 99%

Molecular Cloning and Characterization of a Novel Testis-Specific Nucleoporin-Related Gene

Hd²,

Sy³

et al. 1999

Archives of Andrology

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Section: Discussionmentioning

confidence: 99%

Molecular Cloning and Characterization of a Novel Testis-Specific Nucleoporin-Related Gene

Hd²,

Sy³

et al. 1999

Archives of Andrology

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“…Secondly, ubiquitous expression has been assessed for a short variant encoding the first 18 exons of RGP5, 6, or 7 (they are 100% identical in this part of their sequence; RANBP2L1 isoform 2, RefSeq accession no. NP_115636) (Nothwang et al 1998). Thirdly, ESTs unambiguously matching all of the copies are detectable.…”

Section: Novel Functions Through Genetic Rearrangementsmentioning

confidence: 96%

Complex genomic rearrangements lead to novel primate gene function

Ciccarelli¹,

Mering²,

Suyama³

et al. 2005

Genome Res.

110

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Orthologous genes that maintain a single-copy status in a broad range of species may indicate a selection against gene duplication. If this is the case, then duplicates of such genes that do survive may have escaped the dosage control by rapid and sizable changes in their function. To test this hypothesis and to develop a strategy for the identification of novel gene functions, we have analyzed 22 primate-specific intrachromosomal duplications of genes with a single-copy ortholog in all other completely sequenced metazoans. When comparing this set to genes not exposed to the single-copy status constraint, we observed a higher tendency of the former to modify their gene structure, often through complex genomic rearrangements. The analysis of the most dramatic of these duplications, affecting ∼10% of human Chromosome 2, enabled a detailed reconstruction of the events leading to the appearance of a novel gene family. The eight members of this family originated from the highly conserved nucleoporin RanBP2 by several genetic rearrangements such as segmental duplications, inversions, translocations, exon loss, and domain accretion. We have experimentally verified that at least one of the newly formed proteins has a cellular localization different from RanBP2's, and we show that positive selection did act on specific domains during evolution.

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“…This localization may increase the efficiency with which the RanGAP can hydrolyze Ran-GTP that is exported with karyopherins from the nucleus. However, Nup358/RanBP2, and a closely related gene product, RanBP2L1, are not expressed ubiquitously, so it remains to be established that targeting is the only function of the SUMO modification (63,174). Clearly it is not essential in budding yeast, which does not SUMO modify its RanGAP.…”

Section: Rangapmentioning

confidence: 99%

Transport into and out of the Nucleus

Macara

2001

Microbiol Mol Biol Rev

832

797

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A defining characteristic of eukaryotic cells is the possession of a nuclear envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments occurs through nuclear pore complexes that span the double membrane of this envelope. The molecular basis for transport has been revealed only within the last few years. The transport mechanism lacks motors and pumps and instead operates by a process of facilitated diffusion of soluble carrier proteins, in which vectoriality is provided by compartment-specific assembly and disassembly of cargo-carrier complexes. The carriers recognize localization signals on the cargo and can bind to pore proteins. They also bind a small GTPase, Ran, whose GTP-bound form is predominantly nuclear. Ran-GTP dissociates import carriers from their cargo and promotes the assembly of export carriers with cargo. The ongoing discovery of numerous carriers, Ran-independent transport mechanisms, and cofactors highlights the complexity of the nuclear transport process. Multiple regulatory mechanisms are also being identified that control cargo-carrier interactions. Circadian rhythms, cell cycle, transcription, RNA processing, and signal transduction are all regulated at the level of nucleocytoplasmic transport. This review focuses on recent discoveries in the field, with an emphasis on the carriers and cofactors involved in transport and on possible mechanisms for movement through the nuclear pores

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Identification of a Novel Ran Binding Protein 2 Related Gene (RANBP2L1) and Detection of a Gene Cluster on Human Chromosome 2q11–q12

Cited by 33 publications

References 30 publications

Molecular Cloning and Characterization of a Novel Testis-Specific Nucleoporin-Related Gene

Molecular Cloning and Characterization of a Novel Testis-Specific Nucleoporin-Related Gene

Complex genomic rearrangements lead to novel primate gene function

Transport into and out of the Nucleus

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