Identification of a potential inhibitor for New Delhi metallo-β-lactamase 1 (NDM-1) from FDA approved chemical library- a drug repurposing approach to combat carbapenem resistance

Shailaja, S.; Harshitha, N; Fasim, Aneesa; More, Sunil S.; Mitra, Susweta Das

doi:10.1080/07391102.2022.2123402

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2024

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Cited by 2 publications

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Discovery of adjuvants with antibacterial potentiation activity against carbapenemase-producing Enterobacterales based on in silico virtual screening

Zheng,

Chen,

Song

et al. 2024

International Journal of Antimicrobial Agents

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Discovery of adjuvants with antibacterial potentiation activity against carbapenemase-producing Enterobacterales based on in silico virtual screening

Zheng,

Chen,

Song

et al. 2024

International Journal of Antimicrobial Agents

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Big Data to Expand the Antimicrobial Therapeutic Arsenal

Tarín-Pelló¹,

Suay-García

Falcó

et al. 2024

Advances in Information Quality and Management

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The current big data era has vast amounts of biomedical data that present great interest in processes related to the search of new drugs. Due to the information available in open access databases, many efforts have been directed towards the application of in silico discovery strategies aimed at drug discovery and drug repurposing. These approaches could be useful in finding solutions for antimicrobial resistance, which already causes 700,000 deaths every year. Mathematical prediction models provide a time- and cost-effective solution to this global health threat, as they save all the resources necessary for the development of the molecule. The literature provides computational techniques that have been successfully used in the discovery and repurposing of drugs. For this reason, the aim of this article is to present the different types of prediction models that have been used for the discovery and repurposing of new antimicrobial drugs and to prove the efficiency of these strategies to provide new molecules and therapeutic opportunities to drugs found in biomedical datasets.

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Identification of a potential inhibitor for New Delhi metallo-β-lactamase 1 (NDM-1) from FDA approved chemical library- a drug repurposing approach to combat carbapenem resistance

Cited by 2 publications

References 50 publications

Discovery of adjuvants with antibacterial potentiation activity against carbapenemase-producing Enterobacterales based on in silico virtual screening

Discovery of adjuvants with antibacterial potentiation activity against carbapenemase-producing Enterobacterales based on in silico virtual screening

Big Data to Expand the Antimicrobial Therapeutic Arsenal

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