Identification of a receptor for activated protein kinase C1 (Pm-RACK1), a cellular gene product from black tiger shrimp (Penaeus monodon) interacts with a protein, VP9 from the white spot syndrome virus

Tonganunt, Moltira; Saelee, Netnapa; Chotigeat, Wilaiwan; Phongdara, Amornrat

doi:10.1016/j.fsi.2009.02.002

Cited by 25 publications

(13 citation statements)

References 47 publications

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“…Our previous studies have shown that Pm-RACK1 is up-regulated in the hepatopancreas after WSSV-infection of shrimp [20].…”

Section: Discussionmentioning

confidence: 92%

“…We recently discovered a Pm-RACK1 gene in an EST library of the black tiger shrimp infected with WSSV [20]. We showed that the mRNA of Pm-RACK1 was expressed in all shrimp tissues but was up-regulated in the hepatopancreas, stomach and hemocytes during WSSV infection.…”

Section: Introductionmentioning

confidence: 97%

“…The importance of RACK1 is manifested by its functional roles in a variety of biological processes including signal transduction, cell development, cell growth, cell adhesion and cell survival [16]. It has also been reported to be involved in the host response to viruses such as to Epstein-Barr virus (EBV), and Adenovirus in humans, Walley dermal sarcoma virus (WDSV) in fish and White spot syndrome virus (WSSV) in shrimp [17][18][19][20]. A RACK1 ortholog, Cpc2 protein in fission yeast, is known to regulate cellular defenses against oxidative stress through the positive synthesis of stress responsive catalase, a detoxification enzyme induced by treatment with H 2 O 2 [21].…”

Section: Introductionmentioning

confidence: 99%

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Receptor for Activated C Kinase-1 protein from Penaeus monodon (Pm-RACK1) participates in the shrimp antioxidant response

Saelee

Tonganunt-Srithaworn

Wanna

et al. 2011

International Journal of Biological Macromolecules

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“…Our previous studies have shown that Pm-RACK1 is up-regulated in the hepatopancreas after WSSV-infection of shrimp [20].…”

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Receptor for Activated C Kinase-1 protein from Penaeus monodon (Pm-RACK1) participates in the shrimp antioxidant response

Saelee

Tonganunt-Srithaworn

Wanna

et al. 2011

International Journal of Biological Macromolecules

Self Cite

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“…Up regulation of PmRACK1 during WSSV infection was observed in several organs. Both yeast two-hybrid screening and GST-pull down assay proved that PmRACK1 interacts with a nonstructural protein VP9 [43]. This interaction is perhaps required for regulating the intracellular function of VP9.…”

Section: To Elucidate Wssv Replication and Multiplicationmentioning

confidence: 99%

Host and Virus Protein Interaction Studies in Understanding Shrimp Virus Gene Function

Otta

2012

Indian J. Virol.

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Protein-protein interaction studies have been widely used in several fields to characterize an unknown protein. This in turn helps to find out several pathways to understand a complex mechanism or discover a drug for treatment. Among the methods, yeast two-hybrid has widely been used in human, animal and plant research studies. This aspect of research has also been found useful in understanding the shrimp virus gene function. With respect to White spot syndrome virus, interaction studies have been applied to elucidate virus structure, understand the mode of entry of the virus, mechanism of virus replication and also to discover some of the host anti-viral proteins. Interaction studies on other shrimp viruses are scanty and only few reports available on Yellow head virus and Taura syndrome virus. All these findings are still in preliminary stage and lot more studies are necessary to have the clear picture. Protein interaction research on other shrimp viruses are still lacking. Considering all these, it appears that this field of research has a wide scope to understand the virulence mechanism of shrimp viruses where very little information is available till date.

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“…WSSV has been reported to cause harvest failure with a 100% morbidity and mortality level in three to ten days (Jeswin et al, 2013;Reddy et al, 2013). This virus is an enveloped, double-stranded DNA virus that is classified into genus Whispovirus and family Nimaviridae (Tonganunt et al, 2009). White spot disease can be detected by the appearance of white lesions inside the carapace due to abnormal calcium deposition in the cuticle (Alifuddin et al, 2003;Reddy et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Limited evidence for white spot syndrome virus susceptibility associated with expression of PmVRP15 in local population of giant tiger shrimp (Penaeus monodon)

et al. 2017

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White spot syndrome virus (WSSV) is a devastating viral disease in shrimp aquaculture. Infection of WSSV in penaeid shrimps affects immune defense and changes gene expression. PmVRP15 has been reported as a part of the WSSV propagation pathway that is highly up-regulated in hemocytes at the acute phase of WSSV infection. This study analyzed the expression of PmVRP15 in local populations of giant tiger shrimp (Penaeus monodon) to be associated with susceptibility to WSSV. Tested populations consisted of an inbreeding population (G 8 ) and outbreeding population (G 8iA ) from Jepara, Indonesia. Susceptibility was determined by cumulative mortality, median lethal time (LT 50 ), and severity of infection at time of death. Though all populations were susceptible to WSSV, the first mortality in G 8 occurred at 18 hours post-infection (hpi) with mild infection, while first mortality of G 8iA occurred at 30 hpi with severe infection. The LT 50 of G 8 was significantly lower than that of G 8iA , indicating that G 8iA was less susceptible to WSSV than G 8 . Relative PmVRP15 transcripts of G 8iA were insignificantly down-regulated, whereas relative PmVRP15 transcripts of G 8 were insignificantly upregulated. Although it's still not conclusive, the results of this study suggest that PmVRP15 has weak potential as a WSSV susceptibility marker in G 8 and G 8iA broodstock selection.

show abstract

Identification of a receptor for activated protein kinase C1 (Pm-RACK1), a cellular gene product from black tiger shrimp (Penaeus monodon) interacts with a protein, VP9 from the white spot syndrome virus

Cited by 25 publications

References 47 publications

Receptor for Activated C Kinase-1 protein from Penaeus monodon (Pm-RACK1) participates in the shrimp antioxidant response

Receptor for Activated C Kinase-1 protein from Penaeus monodon (Pm-RACK1) participates in the shrimp antioxidant response

Host and Virus Protein Interaction Studies in Understanding Shrimp Virus Gene Function

Limited evidence for white spot syndrome virus susceptibility associated with expression of PmVRP15 in local population of giant tiger shrimp (Penaeus monodon)

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