1998
DOI: 10.4049/jimmunol.161.11.6273
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Identification of a Truncated Form of the CC Chemokine CKβ-8 Demonstrating Greatly Enhanced Biological Activity

Abstract: A new CC chemokine, designated CKβ-8 or myeloid progenitor inhibitor factor-1, was recently identified in a large scale sequencing effort and was cloned from a human aortic endothelial library. CKβ-8 cDNA encodes a signal sequence of 21 amino acids, followed by a 99-amino acid predicted mature form. CKβ-8 was expressed and purified from a baculovirus insect cell expression system, which resulted in the identification of different N-terminal variants of the secreted chemokine. The three major forms (containing … Show more

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Cited by 24 publications
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