Identification of a unique <i>Staphylococcus aureus</i>
 ribosomal signature in severe atopic dermatitis

Brandwein, Michael; Fuks, Garold; Israel, Avigail; Nejman, Deborah; Straussman, Ravid; Hodak, Emmilia; Harari, Marco; Steinberg, Doron; Bentwich, Zvi; Shental, Noam; Meshner, Shiri

doi:10.1111/bjd.16936

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…B,E), consistent with previous reports . We previously leveraged the high‐resolution microbial community profiling enabled by the SMURF method and identified specific sAD‐associated S. aureus 16S sequences .…”

Section: Discussionsupporting

confidence: 87%

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Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy

Brandwein

Fuks

Israel

et al. 2019

Photochem & Photobiology

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Dead Sea climatotherapy (DSC) is a well‐established therapeutic modality for the treatment of several diseases, including atopic dermatitis. Skin microbiome studies have shown that skin microbiome diversity is anticorrelated with both atopic dermatitis severity and concurrent Staphylococcus aureus overgrowth. This study aimed to determine whether DSC induces skin microbiome changes concurrent with clinical improvements in atopic dermatitis. We sampled 35 atopic dermatitis patients and ten healthy controls on both the antecubital and popliteal fossa. High‐resolution microbial community profiling was attained by sequencing multiple regions of the 16S rRNA gene. Dysbiosis was observed in both lesional and nonlesional sites, which was partially attenuated following treatment. Severe AD skin underwent the most significant community shifts, and Staphylococcus epidermidis, Streptococcus mitis and Micrococcus luteus relative abundance were significantly affected by Dead Sea climatotherapy. Our study highlights the temporal shifts of the AD skin microbiome induced by Dead Sea climatotherapy and offers potential explanations for the success of climatotherapy on a variety of skin diseases, including AD.

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Section: Discussionsupporting

confidence: 87%

“…1B,E), consistent with previous reports (13,18,38). We previously leveraged the high-resolution microbial community profiling enabled by the SMURF method (30) and identified specific sAD-associated S. aureus 16S sequences (39). Dead Sea climatotherapy is a proven modality for the treatment of a variety of skin diseases, including AD (19).…”

Section: Discussionsupporting

confidence: 83%

Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy

Brandwein

Fuks

Israel

et al. 2019

Photochem & Photobiology

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“…Interestingly, only an increase in Staphylococcus relative abundance, and specifically Staphylococcus aureus, was observed in these studies, which also correlated positively with SCORAD [41,44,45]. S. aureus is an important pathogen in atopic dermatitis, as it is a dominant member of the cutaneous bacterial composition in most AD patients [44,46]. Although increased S. aureus abundance is strongly linked to AD severity, the role of Staphylococci in the establishment of AD had not been investigated until recently.…”

Section: The Skin Microbiome In Atopic Dermatitismentioning

confidence: 84%

Microbial interactions in the atopic march

Nibbering

Ubags

2019

Clinical and Experimental Immunology

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Summary The human body is populated by a large number of microorganisms and exist in symbiosis with these immensely diverse communities, which are suggested to influence health and disease. The microbiota plays an essential role in the maturation and function of the immune system. The prevalence of atopic diseases has increased drastically over the past decades, and the co‐occurrence of multiple allergic diseases and allergic sensitization starting in early life has gained a great deal of attention. Immune responses in different organs affected by allergic diseases (e.g. skin, intestine and lung) may be linked to microbial changes in peripheral tissues. In the current review, we provide an overview of the current understanding of microbial interactions in allergic diseases and their potential role in the atopic march.

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“…Regarding WHO region, the majority of studies were conducted in the European Region ( n = 50, 55%), followed by the Western Pacific Region ( n = 21, 23%), the Region of the Americas ( n = 16, 18%) and the African Region and the Eastern Mediterranean Region (both n = 1, 1%). Investigated characteristics included the following categories: skin barrier function ( n = 15), 19–33 serum blood cell types and markers ( n = 23), 9,18,23,34–53 serum Ig levels and sensitization ( n = 15), 20,22,25,51,54–64 microbial colonization ( n = 10), 15,65–73 DNA mutations ( n = 14), 10,51,74–85 skin parameters ( n = 8), 32,86–92 personal and family history of allergy ( n = 4), 58,93–95 comorbidities ( n = 7), 8,51,96–100 morphology ( n = 3) 51,93,101 and other characteristics ( n = 5) 51,95,102–104 (see Table a and Appendix , Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

“…Regarding WHO region, the majority of studies were conducted in the European Region (n = 50, 55%), followed by the Western Pacific Region (n = 21, 23%), the Region of the Americas (n = 16, 18%) and the African Region and the Eastern Mediterranean Region (both n = 1, 1%). Investigated characteristics included the following categories: skin barrier function (n = 15), [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] serum blood cell types and markers (n = 23), 9,18,23,[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] serum Ig levels and sensitization (n = 15), 20,22,25,51,54-64 microbial colonization (n = 10), 15,[65][66][67][68][69][70][71][72][73] DNA mutations (n = 14), 10,51,…”

Section: Phenotypes Based On Disease Severity (Phenotype Group 1)mentioning

confidence: 99%

Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics

Bosma

Ascott

Iskandar

et al. 2022

Acad Dermatol Venereol

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Atopic dermatitis is a heterogeneous disease, accompanied by a wide variation in disease presentation and the potential to identify many phenotypes that may be relevant for prognosis and treatment. We aimed to systematically review previously reported phenotypes of atopic dermatitis and any characteristics associated with them. Ovid EMBASE, Ovid MEDLINE and Web of Science were searched from inception till 12 February 2021 for studies attempting to classify atopic dermatitis. Primary outcomes are atopic dermatitis phenotypes and characteristics associated with them in subsequent analyses. A secondary outcome is the methodological approach used to derive them. In total, 8511 records were found. By focussing only on certain clinical phenotypes, 186 studies were eligible for inclusion. The majority of studies were hospital‐based (59%, 109/186) and cross‐sectional (76%, 141/186). The number of included patients ranged from seven to 526 808. Data‐driven approaches to identify phenotypes were only used in a minority of studies (7%, 13/186). Ninety‐one studies (49%) investigated a phenotype based on disease severity. A phenotype based on disease trajectory, morphology and eczema herpeticum was investigated in 56 (30%), 22 (12%) and 11 (6%) studies respectively. Thirty‐six studies (19%) investigated morphological characteristics in other phenotypes. Investigated associated characteristics differed between studies. In conclusion, we present an overview of phenotype definitions used in literature for severity, trajectory, morphology and eczema herpeticum, including associated characteristics. There is a lack of uniform and consistent use of atopic dermatitis phenotypes across studies.

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Identification of a unique Staphylococcus aureus ribosomal signature in severe atopic dermatitis

Cited by 6 publications

References 8 publications

Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy

Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy

Microbial interactions in the atopic march

Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics

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