Identification of acupuncture-specific proteins in the process of electro-acupuncture after spinal cord injury

Li, Wenjie; Pan, Sanqiang; Zeng, Yuan-Shan; Bao-gui, SU; Li, Shumin; Ding, Ying; Li, Yan; Ruan, Jing-Wen

doi:10.1016/j.neures.2010.04.012

Cited by 37 publications

(32 citation statements)

References 35 publications

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“…The application of EA for the treatment of SCI has shown promising results in the alleviation of the patients' suffering [6]. Previous studies have shown that applications of EA for the treatment of SCI have been proven to contribute to neurologic and functional recoveries in SCI [7–9]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Electroacupuncture at Governor Vessel Acupoints on Neurotrophin-3 in Rats with Experimental Spinal Cord Injury

Yao

et al. 2016

Neural Plasticity

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In an effort to explore new, noninvasive treatment options for spinal cord injuries (SCI), this study investigated the effects of electroacupuncture (EA) for SCI rat models. SCI was induced by a modified Allen's weight-drop method. We investigated the response of EA at Dazhui (GV 14) and Mingmen (GV 4) acupoints to understand the effects and mechanisms of EA in neuroprotection and neuronal function recovery after SCI. BBB testing was used to detect motor function of rats' hind limbs among groups, and EA was shown to promote the recovery of SCI rats' motor function. Nissl staining showed a restored neural morphology and an increase in the quantity of neurons after EA. Also, the antiapoptosis role was exposed by TUNEL staining. Western blotting analysis was used to determine the protein expression of neurotrophin-3 (NT-3) in spinal cord tissue. Compared to the sham group, the expression levels of NT-3 were significantly decreased and EA was shown to upregulate the expression of NT-3. The present study suggests that the role of EA in neuroprotection and dorsal neuronal function recovery after SCI in rats, especially EA stimulation at GV 14 and GV 4, can greatly promote neuronal function recovery, which may result from upregulating the expression of NT-3.

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Section: Introductionmentioning

confidence: 99%

Effects of Electroacupuncture at Governor Vessel Acupoints on Neurotrophin-3 in Rats with Experimental Spinal Cord Injury

Yao

et al. 2016

Neural Plasticity

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“…According to the classical TCM literature, functional differences can be detected between acupoint/acupoint and acupoint/nonacupoint (Campbell, 2006). However, concrete, objective evidence is lacking and point specificity is still a controversial issue (Li et al, 2010b).…”

Section: Omics and Acupoint Specificitymentioning

confidence: 99%

“…Proteomic profiling in animal models showed similar results. For instance, the work suggests that ANXA5 and CRMP2 are acupuncture-specific proteins in GV-EA treatment (Li et al, 2010b).…”

Section: Omics and Acupoint Specificitymentioning

confidence: 99%

A review of Omics research in acupuncture: The relevance and future prospects for understanding the nature of meridians and acupoints

Jia

Deng

et al. 2012

Journal of Ethnopharmacology

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“…Electro-acupuncture (EA) applied at the Governor Vessel acupoints (GV) had been widely used for a range of neurological disorders, including TSCI [19,20,21,22]. Although recent studies show that EA administration during the acute phase of TSCI can contribute to neurological rehabilitation [15,23,24], the EA mechanism of action needs to be elucidated in relation to the secondary mechanisms of TCSI damage.…”

Section: Introductionmentioning

confidence: 99%

Electro-Acupuncture at GV.4 Improves Functional Recovery in paralyzed rats after a Traumatic Spinal Cord Injury

O¹,

H²,

C³

et al. 2016

acupunct electrother res

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In the present study, the effect of electro-acupuncture (EA) on the oxidative stress, the spinal cord tissue preservation and the recovery of motor function was evaluated after a traumatic spinal cord injury (TSCI). Long Evans rats were randomized into five groups: 1. Sham; 2. TSCI without treatment; 3. TSCI + EA (acupoint GV.4); 4. TSCI + EA (acupoint GV.26) and 5.TSCI + EA (GV.4 + GV.26). The EA was performed with an Electro-Acupunctoscope, AWQ-104L Digital, wave dense-dispersed, current intensity 2.5mA and frequency 2-100Hz for 30 minutes. The biochemical results showed a significant increase in the hydroxyl radical concentration in group 2 (3.1±1.4nmol) compared with groups 1 (1.8±0.5nmol) and 4 (2.4±1.1nmol) (p<0.05), whereas in group 4 (4.8±1.8nmol), there was a significant increase in lipid peroxidation when compared with group 1 (1.7±0.5nmol) (p<0.05). The BBB motor function score in the paralyzed hind limbs (normal BBB=21points) was greater in groups 3 (15.2 points) and 5 (13.5 points) in comparison with groups 2 (11.4 points) and 4 (9.3 points) (p<0.05). The quantity of preserved spinal cord tissue was greater in group 3 (6582.7±20µm 2 ) than in groups 2 (5262.4±20µm 2 ), 4 (3995.6±26µm 2 ) and 5 (4266.7±22µm 2 ). Although EA in GV.26 decreases hydroxyl radical concentration (50%), it significantly increases lipid peroxidation (45%), while stimulation of GV.4 decreases oxidative stress (15%), preserves spinal cord tissue (25%) and improves recovery of motor function 356 kARATAY, L.; UzkESER, z. 1 in the hind limbs of rats with paralysis (18.1%) compared with untreated group. These findings suggest that EA in GV.4 may be a therapeutic alternative on TSCI.

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Identification of acupuncture-specific proteins in the process of electro-acupuncture after spinal cord injury

Cited by 37 publications

References 35 publications

Effects of Electroacupuncture at Governor Vessel Acupoints on Neurotrophin-3 in Rats with Experimental Spinal Cord Injury

Effects of Electroacupuncture at Governor Vessel Acupoints on Neurotrophin-3 in Rats with Experimental Spinal Cord Injury

A review of Omics research in acupuncture: The relevance and future prospects for understanding the nature of meridians and acupoints

Electro-Acupuncture at GV.4 Improves Functional Recovery in paralyzed rats after a Traumatic Spinal Cord Injury

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