A review of Omics research in acupuncture: The relevance and future prospects for understanding the nature of meridians and acupoints

Jia, Jinping; Yu, Yan; Deng, Jiahui; Robinson, Nicola; Bovey, Mark; Liu, Huirong; Ding, Wei; Wu, Huangan; Wang, Xiaomin

doi:10.1016/j.jep.2012.01.034

Cited by 39 publications

(27 citation statements)

References 69 publications

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“…This confidence was reflected by the opinions of GP-TCM members in the "Grand Issues" survey and supported by the recent research developments reviewed in this special issue Jia et al, 2012;Pelkonen et al, 2012). Nevertheless, studies using omics and systems biology approaches should be particularly good at generating new hypotheses on mechanisms for the effects of TCM and these hypotheses would need many additional approaches to substantiate them.…”

Section: Resultsmentioning

confidence: 89%

Traditional Chinese medicine research in the post-genomic era: Good practice, priorities, challenges and opportunities

Uzuner

Bauer

Fan

et al. 2012

Journal of Ethnopharmacology

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The GP-TCM consortium made great efforts to address some fundamental issues in TCM research, including developing guidelines, as well as identifying priorities, challenges and opportunities. These consortium guidelines and consensus will need dissemination, validation and further development through continued interregional, interdisciplinary and intersectoral collaborations. To promote this, a new consortium, known as the GP-TCM Research Association, is being established to succeed the 3-year fixed term FP7 GP-TCM consortium and will be officially launched at the Final GP-TCM Congress in Leiden, the Netherlands, in April 2012.

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Section: Resultsmentioning

confidence: 89%

Traditional Chinese medicine research in the post-genomic era: Good practice, priorities, challenges and opportunities

Uzuner

Bauer

Fan

et al. 2012

Journal of Ethnopharmacology

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“…More recently, it has emerged as a complementary therapeutic method for health restoration, promotion, and maintenance 1, 2 . The practice of acupuncture involves the insertion of fine needles into acupuncture points (acupoints) in the body.…”

Section: Introductionmentioning

confidence: 99%

1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation

Lin

Wei

Cheng

et al. 2017

Sci Rep

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Acupuncture is a traditional Chinese medicine therapy that has been found useful for treating various diseases. The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian specificity). This study aims to investigate the metabolic basis of meridian specificity using proton nuclear magnetic resonance (1H NMR)-based metabolomics. Electro-acupuncture (EA) stimulations were performed at acupoints of either Stomach Meridian of Foot-Yangming (SMFY) or Gallbladder Meridian of Foot-Shaoyang (GMFS) in healthy male Sprague Dawley (SD) rats. 1H-NMR spectra datasets of serum, urine, cortex, and stomach tissue extracts from the rats were analysed by multivariate statistical analysis to investigate metabolic perturbations due to EA treatments at different meridians. EA treatment on either the SMFY or GMFS acupoints induced significant variations in 31 metabolites, e.g., amino acids, organic acids, choline esters and glucose. Moreover, a few meridian-specific metabolic changes were found for EA stimulations on the SMFY or GMFS acupoints. Our study demonstrated significant metabolic differences in response to EA stimulations on acupoints of SMFY and GMFS meridians. These results validate the hypothesis that meridian specificity in acupuncture is detectable in the metabolome and demonstrate the feasibility and effectiveness of a metabolomics approach in understanding the mechanism of acupuncture.

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“…In the post-genomic era, the advances of the ''omics'' revolution and the methodology including genomics, proteomics, and metabolomics technologies have all collectively offered a natural bridge between Chinese and Western medicine (Buriani et al, 2012;Jia et al, 2012a;Ouedraogo et al, 2012). The practice of TCM is based on a ''holistic'' philosophy, where Chinese practitioners focus on the inherent balance of the body.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Compatibility art of traditional Chinese medicine: From the perspective of herb pairs

Sheng-peng

Tan

et al. 2012

Journal of Ethnopharmacology

273

158

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A review of Omics research in acupuncture: The relevance and future prospects for understanding the nature of meridians and acupoints

Abstract: This review suggest that disease-oriented studies using the approach of multi-indexed high-throughput technologies and systems biology analyses will be a preferred strategy for future acupuncture/moxibustion research.

Cited by 39 publications

References 69 publications

Traditional Chinese medicine research in the post-genomic era: Good practice, priorities, challenges and opportunities

Traditional Chinese medicine research in the post-genomic era: Good practice, priorities, challenges and opportunities

1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation

Compatibility art of traditional Chinese medicine: From the perspective of herb pairs

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