Compatibility art of traditional Chinese medicine: From the perspective of herb pairs

Stereoselective metabolism of amygdalin-based study of detoxification of Semen Armeniacae Amarum in the Herba Ephedrae–Semen Armeniacae Amarum herb pair

“…Herb pairs are based on established principles known as the ''seven compatibilities'': single action, mutual reinforcement, mutual assistance, mutual restraint, mutual detoxification, mutual inhibition and mutual antagonism (Wang et al, 2012). Although composed of only 2 herbs, herb pairs are the basis of more complex multi-herb formulations and possess most of the basic therapeutic features of such derived formulations (Liu et al, 2012).…”

Proliferative Activity and Neuroprotective Effect of Ligustrazene Derivative by Irritation of Vascular Endothelial Growth Factor Expression in Middle Cerebral Artery Occlusion Rats

“…It has been suggested that some herbal medicines, or their products, may have the functions of improving microcirculation in the brain, protecting against ischemic injury, improving cerebrovascular properties, and inhibiting neuron apoptosis [2][3][4]. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain the growing interest in discovering drugs derived from traditional medicines [5].…”

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AbstractPurpose: To investigate the proliferative activity and neuroprotective effect of a newly identified ligustrazine derivative 5,5, and the possible mechanism related to vascular endothelial growth factor (VEGF) in cerebral ischemic injury.

Methods:The pharmacological activity of T-VA was evaluated using MTT ((3-(4,5-dimethylthiazolyl2-yl

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Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography–tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction

“…So far, the research has faced many obstacles due to the unimaginable complexity of multiherb formula. This applies also to decoctions, the most widely used preparation in clinical practice [1][2][3][4].…”