Identification of animal hosts of Fort Sherman virus, a New World zoonotic orthobunyavirus

Oliveira-Filho, Edmilson F.; Carneiro, Ianei de Oliveira; Ribas, Jorge Raimundo Lins; Fischer, Carlo; Marklewitz, Marco; Junglen, Sandra; Netto, Eduardo Martins; Franke, Carlos Roberto; Drexler, Jan Felix

doi:10.1111/tbed.13499

Cited by 11 publications

(9 citation statements)

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“…Besides, BUNV was also proved to infect free ranging birds (Tauro et al, 2009). In humans, BUNV, Germiston virus (GERV), Ilesha virus (ILEV), Fort Sherman virus (FSV), and Guaroa virus (GROV) are known to cause disease with symptoms such as febrile illness (Schwartz and Allen, 1970;Aguilar et al, 2010;Pachler et al, 2013;Dutuze et al, 2018;de Oliveira Filho et al, 2020), and encephalitis caused by Tensaw virus (TENV; Calisher et al, 1988). Thus, Bunyamwera serogroup viruses are a cause for concern in public and veterinary health (Rogers et al, 2017;Dutuze et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis and Immune Response of Ebinur Lake Virus: A Newly Identified Orthobunyavirus That Exhibited Strong Virulence in Mice

et al. 2021

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Orthobunyaviruses are a group of viruses with significant public and veterinary health importance. These viruses are mainly transmitted through mosquito-, midge-, and tick-vectors, and are endemic to various regions of the world. Ebinur Lake virus (EBIV), a newly identified member of Orthobunyavirus, was isolated from Culex mosquitoes in Northwest China. In the present study, we aimed to characterize the pathogenesis and host immune responses of EBIV in BALB/c mice, as an animal model. Herein, we determined that BALB/c mice are highly susceptible to EBIV infection. The infected mice exhibited evident clinical signs including weight loss, mild encephalitis, and death. High mortality of mice was observed even with inoculation of one plaque-forming unit (PFU) of EBIV, and the infected mice succumbed to death within 5–9 days. After EBIV challenge, rapid viremic dissemination was detected in the peripheral tissues and the central nervous system, with prominent histopathologic changes observed in liver, spleen, thymus, and brain. Blood constituents’ analysis of EBIV infected mice exhibited leukopenia, thrombocytopenia, and significantly elevated ALT, LDH-L, and CK. Further, EBIV infection induced obvious cytokines changes in serum, spleen, and brain in mice. Collectively, our data describe the first study that systematically examines the pathogenesis of EBIV and induced immune response in an immunocompetent standard mouse model, expanding our knowledge of this virus, which may pose a threat to One Health.

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Section: Introductionmentioning

confidence: 99%

Pathogenesis and Immune Response of Ebinur Lake Virus: A Newly Identified Orthobunyavirus That Exhibited Strong Virulence in Mice

et al. 2021

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“…[ 11 – 13 ] to establish a comprehensive list of pathogens that are known to be transmitted by mosquitoes and that cause documented human illness (e.g., fever, death). In one case, Fort Sherman virus, although this pathogen can cause human illness and has been identified as mosquito-borne, no data exist to specify which species are involved (although Aedes are implicated [ 14 ]). All four serotypes of dengue were consolidated to a single pathogen group, as were all species of Plasmodium .…”

Section: Methodsmentioning

confidence: 99%

Robust network stability of mosquitoes and human pathogens of medical importance

et al. 2022

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Background The exact number of mosquito species relevant to human health is unknown, posing challenges in understanding the scope and breadth of vector–pathogen relationships, and how resilient mosquito vector–pathogen networks are to targeted eradication of vectors. Methods We performed an extensive literature survey to determine the associations between mosquito species and their associated pathogens of human medical importance. For each vector–pathogen association, we then determined the strength of the associations (i.e., natural infection, lab infection, lab dissemination, lab transmission, known vector). A network analysis was used to identify relationships among all pathogens and vectors. Finally, we examined how elimination of either random or targeted species affected the extinction of pathogens. Results We found that 88 of 3578 mosquito species (2.5%) are known vectors for 78 human disease-causing pathogens; however, an additional 243 species (6.8%) were identified as potential or likely vectors, bringing the total of all mosquitos implicated in human disease to 331 (9.3%). Network analysis revealed that known vectors and pathogens were compartmentalized, with the removal of six vectors being enough to break the network (i.e., cause a pathogen to have no vector). However, the presence of potential or likely vectors greatly increased redundancies in the network, requiring more than 41 vectors to be eliminated before breaking the network. Conclusion Although < 10% of mosquitoes are involved in transmitting pathogens that cause human disease, our findings point to inherent robustness in global mosquito vector–pathogen networks. Graphical Abstract

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“…In a later study conducted between 2009 and 2012 in North Eastern Kenya, presence of NRIV-neutralizing antibodies was reported among febrile patients ( 21 ), indicating circulation of an understudied virus. With regard to animal infections, NRIV has only been isolated from small ruminants in Mauritania during the 2010 and 2015 Rift Valley Fever (RVF) outbreaks ( 14 , 16 , 22 ), both confirming cocirculation with rift valley fever virus (RVFV) and other orthobunyaviruses, BATV and BUNV.…”

Section: Introductionmentioning

confidence: 99%

Circulation of Ngari Virus in Livestock, Kenya

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Tchouassi

Venter

et al. 2022

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Identification of animal hosts of Fort Sherman virus, a New World zoonotic orthobunyavirus

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 11 publications

References 32 publications

Pathogenesis and Immune Response of Ebinur Lake Virus: A Newly Identified Orthobunyavirus That Exhibited Strong Virulence in Mice

Pathogenesis and Immune Response of Ebinur Lake Virus: A Newly Identified Orthobunyavirus That Exhibited Strong Virulence in Mice

Robust network stability of mosquitoes and human pathogens of medical importance

Circulation of Ngari Virus in Livestock, Kenya

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