Identification of anti-syntaxin 5 autoantibody as a novel serum marker of endometriosis

Nabeta, Motowo; Abe, Yasuhito; Takaoka, Yuki; Kusanagi, Yasuki; M, Ito

doi:10.1016/j.jri.2011.04.012

Cited by 25 publications

(16 citation statements)

References 20 publications

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“…CA 125 is raised in endometriosis through stimulation of coelomic epithelia and is the most investigated non‐invasive diagnosis marker. Individual studies have methodological limitations in patient selection, poor conduct of the index test, and poor conduct of the reference test . Two diagnostic reviews exist; however, the first is over 15 years old and includes studies with high risk of verification bias and the second is of poor methodological quality …”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Hirsch

Duffy

Davis

et al. 2016

BJOG

109

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Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Hirsch

Duffy

Davis

et al. 2016

BJOG

109

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“…С помощью иммуноблоттинга (переноса белков из раствора на какой-либо носитель, где их разделяют, а затем проводят анализ с использованием антител) в сыворотке крови больных с эндометриозом обнаружено по-вышение уровня антисинтаксина-5 и анти-αенолазы, которые могут быть использованы в качестве маркеров в диагностике этого заболевания [27].…”

Section: протеомный метод в диагностике гинекологических заболеванийunclassified

Proteomic analysis methods and their role in the diagnosis of obstetric and gynecological pathology

et al. 2019

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The article presents current literature on proteomic profiling and the role of proteomic technologies in the diagnosis of various obstetric and gynecological diseases. Proteomic analysis is a promising research method, as it allows for a comprehensive study of protein expression and its regulation in the biological systems, which opens up new opportunities for a more in-depth and detailed study of the etiology and pathogenesis, as well as timely diagnosis and treatment of obstetric and gynecological pathology.

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“…Recently, 2DGE and MALDI-TOF-MS data have shown significantly increased serum levels of anti-a-enolase autoantibody in endometriosis patients compared to control (Nabeta et al, 2009). The sensitivity and specificity of serum anti-aenolase autoantibody is similar to serum cancer antigen 125; their combination improves diagnostic sensitivity and accuracy (Nabeta et al, 2009). 2DGE and LC-MS/MS data demonstrate increased urinary enolase-I in endometriosis patients (Cho et al, 2012).…”

Section: B Vitamin D-binding Protein (Dbp)mentioning

confidence: 99%

A mass spectrometric insight into the origins of benign gynecological disorders

Yang

Lau

Yao

et al. 2015

Mass Spectrometry Reviews

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Applications of mass spectrometry (MS) are rapidly expanding and encompass molecular and cellular biology. MS aids in the analysis of in vivo global molecular alterations, identifying potential biomarkers which may improve diagnosis and treatment of various pathologies. MS has added new dimensionality to medical research. Pioneering gynecologists now study molecular mechanisms underlying female reproductive pathology with MS-based tools. Although benign gynecologic disorders including endometriosis, adenomyosis, leiomyoma, and polycystic ovarian syndrome (PCOS) carry low mortality rates, they cause significant physical, mental, and social detriments. Additionally, some benign disorders are unfortunately associated with malignancies. MS-based technology can detect malignant changes in formerly benign proteomes and metabolomes with distinct advantages of speed, sensitivity, and specificity. We present the use of MS in proteomics and metabolomics, and summarize the current understanding of the molecular pathways concerning female reproductive anatomy. Highlight discoveries of novel protein and metabolite biomarkers via MS-based technology, we underscore the clinical application of these techniques in the diagnosis and management of benign gynecological disorders. © 2015 Wiley Periodicals, Inc. Mass Spec Rev 36:450-470, 2017.

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Identification of anti-syntaxin 5 autoantibody as a novel serum marker of endometriosis

Cited by 25 publications

References 20 publications

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Proteomic analysis methods and their role in the diagnosis of obstetric and gynecological pathology

A mass spectrometric insight into the origins of benign gynecological disorders

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