Identification of antibiotics using small molecule variable ligand display on gold nanoparticles

Bresee, Jamee; Maier, Keith E.; Melander, Christian; Feldheim, Daniel L.

doi:10.1039/c0cc02663h

Cited by 31 publications

(35 citation statements)

References 17 publications

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“…Gold nanoparticles display a variety of properties [7] and have important applications as diverse as cosmetics [8], electronics [9], therapeutics [10][11][12], imaging [13,14], drug delivery [15,16], and pollution remediation [17,18]. The mentioned applications often call for monodisperse nanoparticles of a particular size in large quantities and/or at high concentrations [19,20].…”

Section: Introductionmentioning

confidence: 99%

Effect of high gold salt concentrations on the size and polydispersity of gold nanoparticles prepared by an extended Turkevich–Frens method

et al. 2012

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The Turkevich-Frens synthesis starting conditions are expanded, ranging the gold salt concentrations up to 2 mM and citrate/gold(III) molar ratios up to 18:1. For each concentration of the initial gold salt solution, the citrate/gold(III) molar ratios are systematically varied from 2:1 to 18:1 and both the size and size distribution of the resulting gold nanoparticles are compared. This study reveals a different nanoparticle size evolution for gold salt solutions ranging below 0.8 mM compared to the case of gold salt solutions above 0.8 mM. In the case of [Au 3+ ]<0.8 mM, both the size and size distribution vary substantially with the citrate/gold(III) ratio, both displaying plateaux that evolve inversely to [Au 3+ ] at larger ratios. Conversely, for [Au 3+ ]≥0.8 mM, the size and size distribution of the synthesized gold nanoparticles continuously rise as the citrate/gold(III) ratio is increased. A starting gold salt concentration of 0.6 mM leads to the formation of the most monodisperse gold nanoparticles (polydispersity index< 0.1) for a wide range of citrate/gold(III) molar ratios (from 4:1 to 18:1). Via a model for the formation of gold nanoparticles by the citrate method, the experimental trends in size could be qualitatively predicted: the simulations showed that the destabilizing effect of increased electrolyte concentration at high initial [Au 3+ ] is compensated by a slight increase in zeta potential of gold nanoparticles to produce concentrated dispersion of gold nanoparticles of small sizes.

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Section: Introductionmentioning

confidence: 99%

Effect of high gold salt concentrations on the size and polydispersity of gold nanoparticles prepared by an extended Turkevich–Frens method

et al. 2012

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“…Thus, it is essential to evaluate their safety. Previous studies have demonstrated AuNPs are well tolerated in vivo [15], and in vitro toxicity may be primarily related to moieties attached to the nanoparticle, rather than the gold particle itself [12,13,18,24–26]. Here, when administered to mice, no symptoms of toxicity were seen over 24 h. In vitro toxicity was preliminarily evaluated by measuring a marker of early apoptosis over 3 days of exposure, and we found no evidence of toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…P-mercaptobenzoic acid (pMBA) coated AuNPs were synthesized according to our previous publications [12,13]. A solution of 20 mM HAuCl 4 (Strem, MA, USA) dissolved in 20 ml of methanol was combined with 85.0 mM pMBA dissolved in pH 12 ultrapure water.…”

Section: Methodsmentioning

confidence: 99%

Gold Nanoparticles to Improve HIV Drug Delivery

et al. 2015

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Background Antiretroviral therapy (ART) has improved lifespan and quality of life of patients infected with the HIV-1. However, ART has several potential limitations, including the development of drug resistance and suboptimal penetration to selected anatomic compartments. Improving the delivery of antiretroviral molecules could overcome several of the limitations of current ART. Results & Conclusion Two to ten nanometer diameter inorganic gold crystals serve as a base scaffold to combine molecules with an array of properties in its surface. We show entry into different cell types, antiviral activity of an HIV integrase inhibitor conjugated in a gold nanoparticle and penetration into the brain in vivo without toxicity. Herein, gold nanoparticles prove to be a promising tool to use in HIV therapy.

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“…[ 126 ] Examples include analysis of the neurotransmitter dopamine using ferrocene-capped gold nanoparticle/streptavidin conjugates, [ 127 ] identification of anti-biotics [ 128 ] and aflatoxin B1, [ 129 ] as well as application in live-cell imaging. [130] The 3MBA-derived Os3 cluster [Os3(CO)10(µ-H)(3MBA)] 26a has been used to modify silver nanoparticles; TEM analysis showed the presence of spherical particles with an average size of 2.9 ± 0.6 nm.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Coordination chemistry of 3- and 4-mercaptobenzoate ligands: Versatile hydrogen-bonding isomers of the thiosalicylate (2-mercaptobenzoate) ligand

Tiekink

Henderson

2017

Coordination Chemistry Reviews

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This review summarises the coordination chemistry of the isomeric 3-and 4-mercaptobenzoate ligands, derived from HSC6H4COOH, being analogues to the widely-studied 2-mercaptobenzoate (thiosalicylate) ligand. The 3-and 4-mercaptobenzoate ligands show a wide range of coordination modes, including monodentate (through either S or less commonly O), chelation through the carboxylate group alone, as well as a wide range of bridging modes.However, S,O-chelation, which is prevalent for thiosalicylate complexes, is not found in the 3MBA and 4MBA analogues. In the solid-state, complexes of 3MBA and 4MBA ligands containing protonated carboxylic acid groups typically undergo aggregation through formation of classical hydrogen-bonded carboxylic acid dimer motifs, which can be supplemented by additional interactions such as aurophilic (Au···Au) interactions in the case of gold (I) complexes. The hybrid hard-soft nature of 3MBA and 4MBA ligands facilitates the use of these ligands in the construction of early-late heterobimetallic complexes. These ligands also find numerous applications (such as the protection of metallic gold and silver nanoparticles), which are especially prevalent for 4MBA where the para carboxylate/carboxylic acid group is remote from the sulphur coordination site.

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Identification of antibiotics using small molecule variable ligand display on gold nanoparticles

Cited by 31 publications

References 17 publications

Effect of high gold salt concentrations on the size and polydispersity of gold nanoparticles prepared by an extended Turkevich–Frens method

Effect of high gold salt concentrations on the size and polydispersity of gold nanoparticles prepared by an extended Turkevich–Frens method

Gold Nanoparticles to Improve HIV Drug Delivery

Coordination chemistry of 3- and 4-mercaptobenzoate ligands: Versatile hydrogen-bonding isomers of the thiosalicylate (2-mercaptobenzoate) ligand

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