1993
DOI: 10.1128/iai.61.6.2408-2418.1993
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Identification of B-cell epitopes on the S4 subunit of pertussis toxin

Abstract: The main purpose of the present study was to identify B-cell epitopes on the S4 subunit of pertussis toxin (PT) by the synthetic peptide approach. Two strategies were followed: (i) screening of two series of overlapping peptides (12and 25-residue peptides) covering the entire S4 sequence by a panel of murine monoclonal anti-PI antibodies and various polyclonal anti-PT antisera in an enzyme-linked immunosorbent assay (ELISA), and (ii) analysis of the S4 amino acid sequence by a predictive algorithm followed by … Show more

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Cited by 9 publications
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