Identification of Biomarkers of Stent Restenosis With Serum Metabolomic Profiling Using Gas Chromatography/Mass Spectrometry

Hasokawa, Minoru; Shinohara, Masakazu; Tsugawa, Hiroshi; Bamba, Takeshi; Fukusaki, Eiichiro; Nishiumi, Shin; Nishimura, Kunihiro; Yoshida, Masaru; Ishida, Tatsuro; Hirata, Ken Ichi

doi:10.1253/circj.cj-11-0622

Cited by 29 publications

(16 citation statements)

References 34 publications

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“…Elevated sarcosine levels in urine (Sreekumar et al, 2009) and serum (Koutros et al, 2013) have been associated with prostate cancer progression, although this relation has not been observed in other reports (de Vogel et al, 2014; Jentzmik et al, 2011). Elevated urine sarcosine levels were also associated with incident type 2 diabetes (Svingen et al., 2016), while low levels of sarcosine in blood have been linked with advanced arteriosclerosis (Hasokawa et al, 2012) and several neurological disorders, including neuropathic pain (Barthel et al, 2014), cerebral ischemia (Pinto et al, 2014), seizure (Socała et al, 2010), and Parkinson disease (Tsai et al, 2014). More recently, serum sarcosine was shown to be increased by a 10-week aerobic exercise training program in previously untrained male subjects (Felder et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

et al. 2018

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SUMMARY A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of the rat metabolome than age in plasma and tissues. A comparative metabolomic screen in rodents and humans identified circulating sarcosine as being similarly reduced with aging and increased by DR, while sarcosine is also elevated in long-lived Ames dwarf mice. Pathway analysis in aged sarcosine-replete rats identify this biogenic amine as an integral node in the metabolome network. Finally, we show that sarcosine can activate autophagy in cultured cells and enhances autophagic flux in vivo, suggesting a potential role in autophagy induction by DR. Thus, these data identify circulating sarcosine as a biomarker of aging and DR in mammalians and may contribute to age-related alterations in the metabolome and in proteostasis.

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Section: Discussionmentioning

confidence: 99%

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

et al. 2018

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“…Third, besides CKD, new biomarkers that can predict the CHD risk are emerging [55][56][57] . However, our study could not access their importance as have other existing prediction tools for Japanese subjects.…”

Section: Discussionmentioning

confidence: 99%

Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the Framingham Risk Score: The Suita Study

Nishimura

Okamura

Watanabe

et al. 2014

JAT

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183

103

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Aim:The Framingham risk score (FRS) is one of the standard tools used to predict the incidence of coronary heart disease (CHD). No previous study has investigated its efficacy for a Japanese population cohort. The purpose of this study was to develop new coronary prediction algorithms for the Japanese population in the manner of the FRS, and to compare them with the original FRS. Methods: Our coronary prediction algorithms for Japanese were based on a large population-based cohort study (Suita study). The study population comprised 5,521 healthy Japanese. They were followed-up for 11.8 years on average, and 213 cases of CHD were observed. Multiple Cox proportional hazard model by stepwise selection was used to construct the prediction model.

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“…Indolelactic acid is an indole‐containing intermediate of tryptophan metabolism. Although indolelactic acid has not been reported to be related to cardiovascular disease, tryptophan has been shown to be one of eight predictors of major restenosis after PCI . The plasma kynurenine‐to‐tryptophan ratio has been demonstrated to be positively associated with the occurrence of acute coronary events in a Norwegian community .…”

Section: Discussionmentioning

confidence: 99%

Fasting but not changes of plasma metabolome during oral glucose tolerance tests improves the diagnosis of severe coronary arterial stenosis

Hung

Kuo

et al. 2015

Clinical Endocrinology

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Identification of Biomarkers of Stent Restenosis With Serum Metabolomic Profiling Using Gas Chromatography/Mass Spectrometry

Cited by 29 publications

References 34 publications

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the Framingham Risk Score: The Suita Study

Fasting but not changes of plasma metabolome during oral glucose tolerance tests improves the diagnosis of severe coronary arterial stenosis

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