Identification of bursts in spike trains

Cocatre-Zilgien, J.H.; Delcomyn, Fred

doi:10.1016/0165-0270(92)90120-3

Cited by 104 publications

(70 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the histogram method, ISI histograms are used to determine the distribution of burst ISIs when compared with other ISIs in a given spike train (Cocatre-Zielgien and Delcomyn, 1992). However, this method, often used for detecting regular bursting patterns seen in tonically firing neurons, does not detect bursts with highly variable ISIs (Kaneoke and Vitek, 1996).…”

Section: Burst Firing Parametersmentioning

confidence: 99%

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Stevenson

Halliday

Marsden

et al. 2007

Synapse

View full text Add to dashboard Cite

The medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) coordinate various stress responses. Although the effects of stressors on mPFC and BLA activity have been previously examined, it remains unclear to what extent stressors affect functional interactions between these regions. In vivo electrophysiology in the anesthetized rat was used to examine mPFC and BLA activity simultaneously in response to FG-7142, a benzodiazepine receptor partial inverse agonist that mimics various stress responses, in an attempt to model the effects of stressors on corticolimbic functional connectivity. Extracellular unit and local field potential (LFP) recordings, using multielectrode arrays positioned in mPFC and BLA, were conducted under basal conditions and in response to systemic FG-7142 administration. This drug increased mPFC and BLA unit firing at the lowest dose tested, whereas higher doses of FG-7142 decreased various burst firing parameters in both regions. Moreover, LFP power was attenuated at lower (<1 Hz) and potentiated at higher frequencies in mPFC (1-12 Hz) and BLA (4-8 Hz). Interestingly, FG-7142 diminished synchronized unit firing, both within and between mPFC and BLA. Finally, FG-7142 decreased LFP synchronization between these regions. In a separate group of animals, pretreatment with the selective benzodiazepine receptor antagonist flumazenil blocked the changes in burst firing, LFP power and synchronized activity induced by FG-7142, confirming direct benzodiazepine receptor-mediated effects. These results indicate that FG-7142 disrupts corticolimbic network interactions via benzodiazepine receptor partial inverse agonism. Perturbation of mPFC-BLA functional connectivity induced by FG-7142 may provide a useful model of corticolimbic dysfunction induced by stressors.

show abstract

Section: Burst Firing Parametersmentioning

confidence: 99%

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Stevenson

Halliday

Marsden

et al. 2007

Synapse

View full text Add to dashboard Cite

show abstract

“…the coefficient of variation of interspike intervals for the population of TGT neurons (Cocatre-Zilgien and Delcomyn, 1992;Soja et al, 1996a). The origin and nature of this activity are not presently known.…”

Section: State-dependent Changes In Ongoing Spike Dischargementioning

confidence: 99%

Spontaneous Discharge and Peripherally Evoked Orofacial Responses of Trigemino–Thalamic Tract Neurons during Wakefulness and Sleep

et al. 1996

View full text Add to dashboard Cite

In the present study, ongoing and evoked activity of antidromically identified trigemino-thalamic tract (TGT) neurons was examined over the sleep-wake cycle in cats. There was no difference in the mean spike discharge rate of TGT neurons when quiet sleep (QS) and active sleep (AS) were compared with wakefulness (W). However, tooth pulp-evoked responses of TGT neurons were decreased during AS when compared to W. Conversely, the responses of TGT neurons to air puff activation of facial hair mechanoreceptors reciprocally increased during AS when compared to W. The present data demonstrate that ascending sensory information emanating from distinct orofacial areas is differentially modified during the behavioral state of AS. Specifically, the results obtained suggest that during AS, sensory information arising from hair mechanoreceptors is enhanced, whereas information arising from tooth pulp afferents is suppressed. These data may provide functional evidence for an AS-related gate control mechanism of sensory outflow to higher brain centers. Key words: behavioral state; brainstem; hair mechanoreceptor; main sensory nucleus; nucleus oralis; sensory; sleep; tooth pulp; trigeminothalamicThe trigemino-thalamic tract (TGT) is a major somatosensory pathway that conveys sensory information from orofacial regions rostrally to the thalamus and on to the cerebral cortex. Both electrophysiological (Sessle and Greenwood, 1976;Sessle and Hu, 1981;Azerad et al., 1982;Sunada et al., 1990;Ro and Capra, 1994) and anatomical labeling (Mizuno, 1970;Woda et al., 1977;Burton and Craig, 1979;Matsushita et al., 1982;Shigenaga et al., 1986;Matthews et al., 1987Matthews et al., , 1989) studies performed in acute anesthetized cats have demonstrated that the rostral trigeminal sensory nuclear complex (TSNC) comprising, respectively, the nucleus oralis and the main sensory nucleus, contains a high density of TGT neurons. Recently, we have shown that the tooth pulp-evoked activity of rostral TSNC neurons is suppressed specifically during the behavioral state of active (AS) or REM sleep . However, the axonal projection of the recorded cells was not determined.Given the high density of TGT neurons located in the rostral TSNC in concert with our recent findings of AS-related suppression of these neurons, we hypothesize that synaptic transmission via the TGT is suppressed during the behavioral state of AS. To test this hypothesis, the present study was performed to identify TGT neurons and measure their ongoing and peripherally evoked activity recorded during sleep and wakefulness in chronically instrumented behaving cats. The results obtained via stimuli applied to tooth pulp afferents versus facial hair mechanoreceptors suggest that the source of the peripheral input used to activate the recorded neurons is critical in determining the active sleep-related changes that occur in synaptic transmission through the TGT.

show abstract

“…Pausers are expected to have higher skewness values than nonpausers (Schonewille et al, 2006); (2) the coefficient of dispersion (CD; the variance to the mean ratio of the ISI distribution), which is a measure of aggregation of spikes (Cocatre-Zilgien and Delcomyn, 1992). A CD equal to 0 indicates a uniform distribution, whereas a CD equal to 1 is found in a Poissonian distribution.…”

Section: Introductionmentioning

confidence: 99%

Statistical Properties of Pauses of the High-Frequency Discharge Neurons in the External Segment of the Globus Pallidus

Elias¹,

Joshua²,

Goldberg³

et al. 2007

J. Neurosci.

View full text Add to dashboard Cite

The neurons of many basal ganglia nuclei, including the external and internal globus pallidus (GPe and GPi, respectively) and the substantia nigra pars reticulata (SNr) are characterized by their high-frequency (50 -100 spikes/s) tonic discharge (HFD). However, the high firing rate of GPe neurons is interrupted by long pauses. We studied the extracellularly recorded spiking activity of 212 well-isolated HFD GPe and 52 GPi/SNr neurons from five monkeys during different states of behavioral activity. An algorithm that maximizes the surprise function was used to detect pauses and pauser cells ("pausers"). Only 6% of the GPi/SNr neurons versus as many as 56% of the GPe neurons were classified as pausers. The GPe average pause duration equals 0.62 s. The interpause intervals follow a Poissonian distribution with a frequency of 13 pauses/minute. No linear relationship was found between pause parameters (duration or frequency) and the firing rate of the cell. Pauses were preceded by various changes in firing rate but not dominantly by a decrease. The average amplitude and duration of the spike waveform was modulated only after the pause but not before it. Pauses of pairs of cells that were recorded simultaneously were not correlated. The probability of GPe cells to pause spontaneously was extremely variable among monkeys (30 -90%) and inversely related to the degree of the monkey's motor activity. These findings suggest that spontaneous GPe pauses are related to low-arousal periods and are generated by a process that is independent of the discharge properties of the cells.

show abstract

Identification of bursts in spike trains

Cited by 104 publications

References 17 publications

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Spontaneous Discharge and Peripherally Evoked Orofacial Responses of Trigemino–Thalamic Tract Neurons during Wakefulness and Sleep

Statistical Properties of Pauses of the High-Frequency Discharge Neurons in the External Segment of the Globus Pallidus

Contact Info

Product

Resources

About