2003
DOI: 10.4049/jimmunol.171.1.380
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Identification of Circulating Fibrocytes as Precursors of Bronchial Myofibroblasts in Asthma

Abstract: The mechanisms contributing to airway wall remodeling in asthma are under investigation to identify appropriate therapeutic targets. Bronchial myofibroblasts would represent an important target because they play a crucial role in the genesis of subepithelial fibrosis, a characteristic feature of the remodeling process, but their origin is poorly understood. We hypothesized that they originate from fibrocytes, circulating cells with the unique characteristic of expressing the hemopoietic stem cell Ag CD34 and c… Show more

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Cited by 579 publications
(670 citation statements)
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“…Fibrocytes also release proteases, growth factors, and pro-inflammatory chemokines [66] including interleukin-8 (IL-8) [67,68] and VEGF [69]. Asthmatic individuals have been found to have increased levels of circulating fibrocytes [70,71], as well as more fibrocytes in the airway submucosa following an allergen challenge [72]. Fibrocytes could be playing a significant role in multiple features of the remodelled asthmatic airway.…”
Section: Fibrocytesmentioning
confidence: 99%
“…Fibrocytes also release proteases, growth factors, and pro-inflammatory chemokines [66] including interleukin-8 (IL-8) [67,68] and VEGF [69]. Asthmatic individuals have been found to have increased levels of circulating fibrocytes [70,71], as well as more fibrocytes in the airway submucosa following an allergen challenge [72]. Fibrocytes could be playing a significant role in multiple features of the remodelled asthmatic airway.…”
Section: Fibrocytesmentioning
confidence: 99%
“…Fibrocytes were identified by dual immunohistochemical techniques on formalin-fixed, paraffin-embedded tissue specimens using specific antibodies against CD45 and type I pro-collagen α 1 as described previously [13]. Briefly, CD45 was detected by the indirect avidin-biotinylated alkaline phosphatase method using a murine anti-human CD45 monoclonal antibody (DAKO, Glostrup, Denmark).…”
Section: Immunohistochemical Studiesmentioning
confidence: 99%
“…However, the recruitment and proliferation of circulating stem and progenitor cell populations, for example mesenchymal stem cells, endothelial progenitor cells and fibrocytes, have been reported (Schmidt et al, 2003;Zernecke et al, 2005;Jin et al, 2006;Massberg et al, 2006). While it is equally feasible that resident structural cells partake in tissue remodelling, there is an increasing body of evidence from studies of diseases with remodelling phenomena which suggest these processes may be greatly enhanced by the participation of progenitor cells, as they become recruited and undergo in situ proliferation and differentiation according to the micro-environment (Schmidt et al, 2003;Zernecke et al, 2005;Jin et al, 2006;Massberg et al, 2006). Interestingly, platelet-derived SDF-1a has been shown to be necessary for 'hermangioblast' mobilization from the bone marrow (Jin et al, 2006), while platelet P-selectin has been shown to be required for their recruitment to inflamed endothelium in models of atherosclerosis (Massberg et al, 2006).…”
Section: Platelets and Tissue Remodelling Eventsmentioning
confidence: 99%