Identification of coronavirus sequences in carp cDNA from Wuhan, China

Conway, Michael J.

doi:10.1002/jmv.25751

Cited by 14 publications

(10 citation statements)

References 7 publications

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“…The epidemiology and pathophysiology of COVID-19 remains totally unelucidated at this moment. Although several reports claimed the sequencing of SARS-CoV-2 RNA has been determined [5,20], how and where this RNA virus metamorphoses have not yet been fully understood. Clinical phenotypes also widely vary depending upon the regions as shown in hundreds of case reports: from asymptomatic to severe acute respiratory failure, multiple organ failure, and systemic thrombosis [1,21].…”

Section: Discussionmentioning

confidence: 99%

Characteristics, laboratories, and prognosis of severe COVID-19 in the Tokyo metropolitan area: A retrospective case series

Mori

Otomo

2020

PLoS ONE

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The impact of the COVID-19 pandemic has been immense, while the epidemiology and pathophysiology remain unclear. Despite many casualties in many countries, there have been less than 1,000 deaths in Japan as of end of June, 2020. In this study, we analyzed the cases of COVID-19 patients admitted to our institution located in the Tokyo metropolitan area where the survival rate is higher than those in other cities in the world. Medical records of COVID-19 patients that were admitted to a single Japanese tertiary university hospital in the Tokyo metropolitan area between March 10th and June 2nd, 2020 were retrospectively reviewed. The identified COVID-19 cases were subdivided into two groups (severe and mild) depending on the need for mechanical ventilation. Those in the severe group required mechanical ventilation as opposed to those in the mild group. The data were analyzed using nonparametric tests expressed by median [interquartile range (IQR)]. A total of 45 COVID-19 patients were included, consisting of 22 severe cases (Group S) and 23 mild cases (Group M). Male sex (Group S, 95.5% vs. Group M, 56.5%, p<0.01), high body mass index (Group S, 24.89 [22.44-27.15] vs. Group M, 21.43 [19.05-23.75], p<0.01), and hyperlipidemia (Group S, 36.4% vs. Group M, 0%, p<0.01) were more seen in Group S. Five (22.7%) cases in Group S underwent extracorporeal membranous oxygenation (ECMO). On admission, lymphopenia, decreased albumin, and elevated fibrinogen, lactate dehydrogenase, transaminases, creatine kinase, C-reactive protein, and procalcitonin were observed in Group S. The median ICU and hospital stay were 13.5 [10.3-22.3] days and 23.0 [16.3-30.5] days, respectively, in Group S. As of June 28th, 2020, in Group S, 19 (86.4%) patients have survived, of which 17 (77.3%) were discharged, and 2 are still in treatments. Three died of multiple organ failure. All 23 patients in Group M have recovered. Male sex, high body mass index, and hyperlipidemia can be risk factors for severe COVID-19 pneumonia, and its overall short-term survival rate was between 77.3% and 86.4% in this study.

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Section: Discussionmentioning

confidence: 99%

Characteristics, laboratories, and prognosis of severe COVID-19 in the Tokyo metropolitan area: A retrospective case series

Mori

Otomo

2020

PLoS ONE

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“…However, there may be one or more unkonwn intemediate hosts between bats and humans, just as the intermediate host of SARS-CoV is civet cat and the intermediate host of MERS is dromedary camel [49,50]. Most of the original SARS-CoV-2 infections came from a local seafood market in Wuhan [51]. The internal environment of the market was similar to the place where SARS-CoV was discovered in 2003 [52].…”

Section: Source Of Infectionmentioning

confidence: 99%

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review

et al. 2020

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In recent years, the prevalence and spread of coronavirus has had a huge impact on global public health. Due to the incomplete understanding of the pathogenic mechanism of the virus, it is difficult for humans to fight against the virus quickly and effectively once the outbreak occurs. In early 2020, a novel coronavirus was discovered in Wuhan, China. Soon after, similar cases were found in other countries around the world, and the number of infected people increased rapidly. So far, the global cumulative number of infected people has exceeded 3 million, and more than 200,000 people have died, which has had a huge impact on global human health and economic development. Every outbreak of disease makes a deep impression on mankind. Herein, we summarize the virology, epidemiology, clinical manifestations, diagnosis, treatment and prevention of SARS-CoV-2, and hope that countries can control the outbreak as soon as possible to minimize the loss.

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“…SARS-CoV-2 have the largest genomes found in any RNA virus. The genome of SARS-CoV-2, ranging from 26 to 29 kilobases in length, containing 14 open reading frames (ORFs) [8] encoding 27 proteins [9]. Moreover, the spike which is divided into the S1 domain (responsible for receptor binding) and S2 domain (responsible for cell membrane fusion ) surface glycoprotein plays an essential role in binding to receptors on the host cell and is crucial for determining host tropism and transmission capacity, mediating receptor binding and membrane fusion [10].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 constitution: The second and most contagious pandemic of the 21st century

Saha

Rahaman

Sultana

2020

Preprint

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SARS-CoV-2, appeared in winter 2019, in Wuhan State of Hubei Province in China, which has already marched more than 210 countries with 5,418,496 cases and 344,206 fatalities. Through an ongoing unprecedented global public health effort, the pandemic is now slowing down slightly after 6 months of its original occurrence. Until now, the media coverage is incredibly accurate and has been providing worldwide pictures to enrich scientific data. As of May 25, 2019, there are more than 21000 citations related to SARS-CoV-2 in the medical literature according to the WHO on global research on coronavirus disease 2019 (COVID-19). However, among these citations, only 5-10% are related to laboratory experimental data. This review is aimed to analyze the unique laboratory experiment aspects of SARS-CoV-2, to describe the epidemiology, threat to pediatric and women health, mutational intimidation, diagnostics and treatment of the SARS-CoV-2 in regard to future epidemics, and to use the SARS-CoV-2 experience as a model for future pandemics.

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Identification of coronavirus sequences in carp cDNA from Wuhan, China

Cited by 14 publications

References 7 publications

Characteristics, laboratories, and prognosis of severe COVID-19 in the Tokyo metropolitan area: A retrospective case series

Characteristics, laboratories, and prognosis of severe COVID-19 in the Tokyo metropolitan area: A retrospective case series

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review

SARS-CoV-2 constitution: The second and most contagious pandemic of the 21st century

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