Identification of Cytotoxic Constituent of Indonesian Sponge Kaliapsis sp. (Bowerbank)

Setyowati, Erna P.; Jenie, Umar Anggara; Sudarsono, Sudarsono; Kardono, L.B.S.; Rahmat, Rachmaniar

doi:10.3923/pjbs.2008.2560.2566

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Compound 2 was reported to be first isolated from fungi Aspergillus fumigatus, with antimicrobial activities (Furtado et al 2005). The pyrimidine derivative Compound 3 was originally isolated from sponge, with in vitro cytotoxicity (HeLa, Raji and myolema cells) bioactivities (Setyowati et al 2008). Compound 4 was originally developed as a synthetic analogue from spongouridine, a compound isolated from the Caribbean sponge Tethya crypta (Tethylidae) with good antiviral activity (Bergmann et al 1951).…”

Section: Resultsmentioning

confidence: 99%

“…This paper reports the isolation and elucidation of secondary metabolites from G. antarctica PI12 fermented at 12°C with complete nutrient (optimised growth conditions). A new dipeptide, (-)glaciantarcin (1) and three known compounds, cyclo(-Pro,Gly) (2) (Ishizu et al 1991), 1-(2-deoxypentofuranosyl)-5-methyl-2,4(1H,3H)pyrimidinedione (Setyowati et al 2008) and vidarabine (Ara-A) (4) (Lagoja 2005), were isolated from the ethyl acetate extract of G. antarctica PI12 and their structures were established by Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry techniques. The antioxidant properties and cytotoxicity activity of compounds 1-4 against two cancer cell lines, MCF-7 and PC-3 and the normal cell line HEK 293 are also included.…”

Section: Introductionmentioning

confidence: 99%

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(-)-Glaciantarcin, a New Dipeptide and Some Secondary Metabolites from the Psychrophilic Yeast Glaciozyma antarctica PI12

Rosandy

Ying

Kqueen

et al. 2018

JSM

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A new dipeptide, (-)-glaciantarcin (1) and three known compounds, cyclo(-Pro-Gly) (2), 1-(2-deoxypentofuranosyl)-5methyl-2,4(1H,3H)-pyrimidinedione (3) and vidarabine (Ara-A) (4), were isolated from Glaciozyma antarctica PI12, a cold-adapted yeast. The chemical structures were elucidated by FT-IR, NMR and mass spectrometry. The cytotoxicity and antioxidant activities of compounds 1-4 were evaluated by using the MTT bioassay on MCF-7 (human breast cancer cell line), PC-3 (human prostate cancer cell line) and HEK-293 (normal human embryonic kidney cell line) and DPPH free radical scavenging activity, respectively. At concentration of 400 µM, all compounds showed the highest activity on MCF-7, with compound 1 at 65%, compound 2 (70%), compound 3 (66%) and compound 4 (58%) cell viability. All compounds exhibited weak antioxidant properties. To the best of our knowledge, this is the first report of compounds 1-4 from Glaciozyma antactica.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

(-)-Glaciantarcin, a New Dipeptide and Some Secondary Metabolites from the Psychrophilic Yeast Glaciozyma antarctica PI12

Rosandy

Ying

Kqueen

et al. 2018

JSM

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“…Penemuan ini menuntun para peneliti untuk mensintesis analog-analognya yaitu Adenin arabinosa (Ara-A, Vidarabine ® , Vidarabin Thilo ® ) dan Sitosin arabinosa (Ara-C, Cytarabine, Alexan ® , Udicil ® ) telah terbukti meningkatkan aktivitas antivirus. (Garcia et al, 2007;Setyowati et al, 2008) Dilaporkan oleh Mebhub (2014) …”

Section: Traditional Medicine Journal 22(3) 2017unclassified

Penares sp sponge from Menjangan Island-water West Bali National Park: Isolation of Cytotoxic Compounds

2017

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Marine Natural Products from Indonesian Waters

et al. 2019

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Natural products are primal and have been a driver in the evolution of organic chemistry and ultimately in science. The chemical structures obtained from marine organisms are diverse, reflecting biodiversity of genes, species and ecosystems. Biodiversity is an extraordinary feature of life and provides benefits to humanity while promoting the importance of environment conservation. This review covers the literature on marine natural products (MNPs) discovered in Indonesian waters published from January 1970 to December 2017, and includes 732 original MNPs, 4 structures isolated for the first time but known to be synthetic entities, 34 structural revisions, 9 artifacts, and 4 proposed MNPs. Indonesian MNPs were found in 270 papers from 94 species, 106 genera, 64 families, 32 orders, 14 classes, 10 phyla, and 5 kingdoms. The emphasis is placed on the structures of organic molecules (original and revised), relevant biological activities, structure elucidation, chemical ecology aspects, biosynthesis, and bioorganic studies. Through the synthesis of past and future data, huge and partly undescribed biodiversity of marine tropical invertebrates and their importance for crucial societal benefits should greatly be appreciated.

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Identification of Cytotoxic Constituent of Indonesian Sponge Kaliapsis sp. (Bowerbank)

Cited by 5 publications

References 7 publications

(-)-Glaciantarcin, a New Dipeptide and Some Secondary Metabolites from the Psychrophilic Yeast Glaciozyma antarctica PI12

(-)-Glaciantarcin, a New Dipeptide and Some Secondary Metabolites from the Psychrophilic Yeast Glaciozyma antarctica PI12

Penares sp sponge from Menjangan Island-water West Bali National Park: Isolation of Cytotoxic Compounds

Marine Natural Products from Indonesian Waters

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