Identification of DNA single-base mismatches by resistivity of poly(N-isopropylacrylamide)-block-ssDNA copolymer brush films at dual temperatures

Liu, Yi Zu; Manivannan, Karthikeyan; Lee, Ai Wei; Huang, Yan; Wei, Po Li; Chen, Jem-Kun

doi:10.1039/c6ra28270a

RSC Adv.

2017

DOI: 10.1039/c6ra28270a

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Identification of DNA single-base mismatches by resistivity of poly(N-isopropylacrylamide)-block-ssDNA copolymer brush films at dual temperatures

Yi Zu Liu

Karthikeyan Manivannan

Ai Wei Lee

et al.

Abstract: The resistivity of tethered PNIPAAm-b-ssDNA copolymer brushes can be exploited to detect a label-free target by homogeneous complexation and phase separation.

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Cited by 5 publications

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Poly(N‐isopropylacrylamide) and Its Copolymers: A Review on Recent Advances in the Areas of Sensing and Biosensing

Das,

Babu,

Chakraborty

et al. 2024

Adv Funct Materials

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Stimuli‐responsive polymers have received increasing attention for various applications due to their ability to adapt physical and chemical properties in response to external environmental stimuli. In this regard, poly(N‐isopropylacrylamide) (PNIPAM) is the most extensively studied stimuli‐responsive polymer and, consequently has been prominently featured in (bio)‐sensor development, adaptive coating technology, drug delivery, wound healing, tissue regeneration, artificial actuator design, sensor technology, responsive coatings, and soft robotics. This success can be mainly attributed to the accessible and versatile nature of the PNIPAM platform, thus allowing the synthesis of a wide variety of copolymer architectures, topologies and compositions. Within this review, the structural and compositional features of PNIPAM‐based materials in sensor and biosensor applications are discussed with a focus on the literature from 2016 until now. The reader is provided with the current state of the art regarding PNIPAM‐based sensor development and their molecular design. Finally, the challenges ahead in the successful implementation of PNIPAM‐based sensors are highlighted, as well as the opportunities in the rational design of improved PNIPAM‐based sensors. Altogether, this review provides comprehensive insights into the exciting and rapidly expanding field of PNIPAM‐based sensing systems, which will benefit the chemical, pharmaceutical, textile, and biotech industries is believed.

show abstract

Poly(N‐isopropylacrylamide) and Its Copolymers: A Review on Recent Advances in the Areas of Sensing and Biosensing

Das,

Babu,

Chakraborty

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

Protein valves prepared by click reaction grafting of poly(N-isopropylacrylamide) to electrospun poly(vinyl chloride) fibrous membranes

Guo

Lin

Chang

et al. 2018

Applied Surface Science

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Immobilization of antibody conjugated ZnS quantum dots onto poly(2,6-dimethyl-1,4-phenylene oxide) nanofibers with Poly(N-isopropylacrylamide) grafts as reversibly fluorescence immunoassay

Guo

Wei

et al. 2018

Dyes and Pigments

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Identification of DNA single-base mismatches by resistivity of poly(N-isopropylacrylamide)-block-ssDNA copolymer brush films at dual temperatures

Abstract: The resistivity of tethered PNIPAAm-b-ssDNA copolymer brushes can be exploited to detect a label-free target by homogeneous complexation and phase separation.

Cited by 5 publications

References 40 publications

Poly(N‐isopropylacrylamide) and Its Copolymers: A Review on Recent Advances in the Areas of Sensing and Biosensing

Poly(N‐isopropylacrylamide) and Its Copolymers: A Review on Recent Advances in the Areas of Sensing and Biosensing

Protein valves prepared by click reaction grafting of poly(N-isopropylacrylamide) to electrospun poly(vinyl chloride) fibrous membranes

Immobilization of antibody conjugated ZnS quantum dots onto poly(2,6-dimethyl-1,4-phenylene oxide) nanofibers with Poly(N-isopropylacrylamide) grafts as reversibly fluorescence immunoassay

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