Identification of Enterohepatic
            <i>Helicobacter</i>
            Species in Patients Suffering from Inflammatory Bowel Disease

Bohr, Ulrich R. M.; Glasbrenner, Bernhard; Primus, Anett; Zagoura, Alexandra; Wex, Thomas; Malfertheiner, Peter

doi:10.1128/jcm.42.6.2766-2768.2004

Cited by 79 publications

(77 citation statements)

References 23 publications

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“…Thus, in the earliest studies on the subject, it was not possible to detect DNA of any EHH in colonic mucosa samples (80). However, more recent studies have found a statistically significant relation between EHH and IBD (83,84). Laharie et al (81) analyzed the presence of DNA of these bacteria by PCR in a total of 44 samples obtained by colonoscopy in patients with Crohn´s disease and healthy controls.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

“…Thus, H. pullorum, H cinaedi, H. canis, H. bilis and H. muridarum have been described as responsible for this type of condition in poultry and domestic animals (4). In humans, these microorganisms have been detected by PCR in stools of patients with acute gastroenteritis (8,(71)(72)(73)(74)(75) and have been related with cases of Meckel´s diverticulum (76)(77)(78), acute appendicitis (79) and with inflammatory bowel disease (80)(81)(82)(83)(84)(85).…”

Section: Ehh and Intestinal Diseasementioning

confidence: 99%

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Enterohepatic Helicobacter other than Helicobacter pylori

Mateos-Muñoz

Pérez-de-la-Serna

Ruiz-de-León

et al. 2013

Rev. esp. enferm. dig.

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The Helicobacter genus includes Gram negative bacteria which were originally considered to belong to the Campylobacter genus. They have been classified in a separate genus since 1989 because they have different biochemical characteristics, with more than 24 species having been identified and more still being studied.H. pylori is the best known. It has an important etiopathogenic role in peptic ulcer disease and gastric cancer. Enterohepatic Helicobacters (EHH) other than H. pylori colonize the bowel, biliary tree and liver of animals and human beings with pathogenic potential. The difficulties existing to correctly isolate these microorganisms limit the description of their true prevalence and of the diseases they cause. Many studies have tried to discover the different clinical implications of EHH. Diseases like chronic liver disease, autoimmune hepatitis, hepatocarcinoma, autoimmune hepatobiliary disease, biliary lithiasis, cholangiocarcinoma and gallbladder cancer, Meckel´s diverticulum, acute appendicitis and inflammatory bowel disease have been related with different EHH species with different results, although their prevalence is greater than in healthy subjects. However, these data are currently not sufficient to draw definitive conclusions. Finally, the best known role of EHH in bowel disease is production of acute and chronic diarrhea pictures initially referred to as Campylobacter. H. pullorum has been identified in patients with acute gastroenteritis. The correct identification of EHH as producers of infectious gastroenteritis is found in its antibiotic susceptibility. It is generally macrolidesusceptible and quinolone-resistant.

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Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Section: Ehh and Intestinal Diseasementioning

confidence: 99%

Enterohepatic Helicobacter other than Helicobacter pylori

Mateos-Muñoz

Pérez-de-la-Serna

Ruiz-de-León

et al. 2013

Rev. esp. enferm. dig.

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“…Currently, the data on whether the presence of Helicobacter species is increased in patients with IBD are inconclusive. While some studies have found an increased prevalence rate (3,10,12,14,18,21), other studies have found otherwise (1, 2, 5, 7, 13). Discrepancies among studies may be explained by geographical and genetic differences among countries and populations and/or differences in disease stage, the length of time since initial diagnosis, and previous antibiotic or other treatments received.…”

mentioning

confidence: 90%

Role of Helicobacter Species in Chinese Patients with Inflammatory Bowel Disease

et al. 2011

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Based on 16S rRNA gene PCR, no significant difference was observed in rates of detection of Helicobacter species in intestinal biopsy specimens from 160 Chinese inflammatory bowel disease (IBD) patients (10%) and 80 controls (6.3%). By using a [ 13 C]urea breath test, the H. pylori infection rate in 208 Chinese IBD patients (19.7%) was found to be significantly lower than that in 416 controls (48.8%).

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“…In our study of 72 patients (35 with IBD), Helicobacter species were detected in only 6 subjects (3 IBD, 3 controls) 82 . In another study, Helicobacter species were not detected in any of the 50 patients or 25 controls 83 , yet in a third study, 6 Helicobacter species were detected in 43 patients and only once in 23 controls 84 . A study using culture, detected only H. pylori on the colonic mucosa but there was no correlation with disease 85 .…”

Section: Non-pylori Helicobacter Speciesmentioning

confidence: 99%

Helicobacter Pylori: Current Status and Future Prospects

O’Mahony¹,

Vaira

Holton³

et al. 2004

Science Progress

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Helicobacter pylori is a global pathogen that causes severe gastrointestinal diseases leading to a significant morbidity and mortality. There is an effective treatment for peptic ulcer disease, however, this is being compromised by an increase in the prevalence of antibiotic resistance. Although alternative rescue regimens have been advocated, the best strategy would be to prevent disease, especially in the case of gastric cancer for which there is still no treatment. One approach is to inhibit the first step in the pathogenic process-adhesion of the organism to the host tissue. Another and probably a better approach is vaccination, but clinical trials have so far been unsuccessful. There is still a large uncertainty in relation to how H. pylori causes disease. Knowledge from genomics, proteomics, and the relationship between polymorphism of the bacterium and the host, as well as the continuing investigation of the role played by important virulence factors in the outcome of the disease, will help both in understanding pathogenesis of disease and in the design of the best vaccine.

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Identification of Enterohepatic Helicobacter Species in Patients Suffering from Inflammatory Bowel Disease

Cited by 79 publications

References 23 publications

Enterohepatic Helicobacter other than Helicobacter pylori

Enterohepatic Helicobacter other than Helicobacter pylori

Role of Helicobacter Species in Chinese Patients with Inflammatory Bowel Disease

Helicobacter Pylori: Current Status and Future Prospects

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