Identification of extracapsular invasion of the metastatic lymph nodes as a useful prognostic sign in patients with resectable colorectal cancer

Komuta, Ko; Okudaira, Sadayuki; Haraguchi, Masashi; Furui, Junichiro; Kanematsu, Takashi

doi:10.1007/bf02234464

Cited by 40 publications

(37 citation statements)

References 9 publications

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“…Many investigators have reported that, in patients with various malignancies, the pathological characteristics of metastatic nodes could be associated with survival [2][3][4][5][6]: however, some of the populations [3,6] might not be selected properly in the previous studies. In patients with localized gastric cancer, the number of metastatic nodes and the presence of serosal invasion were the strongest prognosticators, the latter being associated with peritoneal metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of extracapsular invasion and fibrotic focus in single lymph node metastasis of gastric cancer

Okamoto¹,

Tsuburaya

Konishi

et al. 2008

Gastric Cancer

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Section: Discussionmentioning

confidence: 99%

“…Numerous reports have assessed the correlation between the histology of lymph node metastasis and patients' prognoses in various types of tumors, including breast and colorectal tumors [4,5]. The presence of extracapsular invasion (ECI) has been reported to be a signifi cant prognostic factor in patients with gastric cancer [3,6].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of extracapsular invasion and fibrotic focus in single lymph node metastasis of gastric cancer

Okamoto¹,

Tsuburaya

Konishi

et al. 2008

Gastric Cancer

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“…4,12 ECE of lymph node metastasis has been shown to be prognostic in patients with malignancies of breast, gastrointestinal tract, prostate, and penis. [16][17][18][19] To our knowledge, the only published reports on the significance of ECE in bladder cancer are from the University of Bern, Switzerland. [4][5][6] They found that ECE was an independent prognostic factor for RFS in a retrospective analysis from 1985-2000 that included 101 patients with lymph node metastasis at time of radical cystectomy.…”

Section: Discussionmentioning

confidence: 99%

Relevance of extracapsular extension of pelvic lymph node metastasis in patients with bladder cancer treated in the contemporary era

Kassouf

Leibovici

Luongo

et al. 2006

Cancer

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Disease overview: Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis fungoides (MF) or Sézary syndrome (SS). Diagnosis: The diagnosis of MF or SS requires the integration of clinical and histopathologic data. Risk‐adapted therapy: Tumor, node, metastasis, and blood (TNMB) staging remains the most important prognostic factor in MF/SS and forms the basis for a “risk‐adapted,” multidisciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin‐directed therapies is preferred, as both disease‐specific and overall survival for these patients is favorable. In contrast, patients with advanced‐stage disease with significant nodal, visceral, or blood involvement are generally approached with biologic‐response modifiers, denileukin diftitox, and histone deacetylase inhibitors before escalating therapy to include systemic, single‐agent chemotherapy. Multiagent chemotherapy may be used for those patients with extensive visceral involvement requiring rapid disease control. In highly‐selected patients with disease refractory to standard treatments, allogeneic stem‐cell transplantation may be considered. Am. J. Hematol., 2011. © 2011 Wiley‐Liss, Inc.

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“…13 Several manuscripts have shown that delays of more than 12 weeks bewteen TURBT and RC significantly correlated with higher rates of nonorgan confined disease and with cancer-specific and overall mortality. [7][8][9][10][11] These findings cannot be generalized to patients with bladder cancer treated with PC because this constitutes a select category of patients with a favourable disease profile and presumably better prognostic potential. To date, no study has investigated the impact of delaying PC on disease outcome.…”

Section: Discussionmentioning

confidence: 99%

“…We and others have shown that delaying RC is significantly associated with worse outcome. [7][8][9][10][11] However, no studies have evaluated treatment delays among patients who underwent PC. The goal of the present study was to investigate variables associated with delays between transurethral resection of bladder tumours (TURBT) and PC and to examine the impact of such delays on disease outcome.…”

Section: Discussionmentioning

confidence: 99%

Impact of treatment delay in patients with bladder cancer managed with partial cystectomy in Quebec: a population-based study

Fahmy

Aprikian

Alotaibi

et al. 2013

CUAJ

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Objective: Treatment delays have been associated with adverse outcomes in patients with bladder cancer treated with radical cystectomy (RC). We sought to evaluate the impact of treatment delay on disease recurrence and survival in patients with bladder cancer treated with partial cystectomy (PC) in Quebec. Results: A total of 714 patients underwent PC. The median patient age was 70 years. Two-hundred nineteen (30.7%) patients experienced recurrence; of these, 52 (23.7%) required salvage RC. Five-year overall and recurrence-free survival for patients who underwent PC were 49.8% and 40.3%, respectively. Patients delayed more than 12 weeks from transurethral resection of bladder tumours (TURBT) to PC were at significantly increased risk of requiring salvage RC compared with those delayed 12 weeks or less (hazard ratio [HR] 3.0, p < 0.001). Patients who underwent salvage RC had worse survival than patients who had upfront RC (HR 1.5, p = 0.006). Variables including age, sex, presence of hematuria, intravesical therapy, surgeon age, hospital PC volume, surgeon PC volume, type of hospital (academic v. nonacademic) or year of surgery were not significantly associated with PC treatment delay. Methods Conclusion:Treatment delay in patients with bladder cancer managed with PC was associated with increased risk of salvage RC. Patients with bladder cancer who underwent salvage RC had worse outcomes than those who had upfront cystectomy. RésuméObjectif : Chez les patients atteints de cancer de la vessie traités par cystectomie radicale (CR), un délai avant l'instauration du traitement est associé à des résultats défavorables. Nous avons tenté d'évaluer l'impact d'un tel délai sur la récidive de la maladie et le taux de survie des patients atteints de cancer de la vessie traités par cystectomie partielle (CP) au Québec.

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Identification of extracapsular invasion of the metastatic lymph nodes as a useful prognostic sign in patients with resectable colorectal cancer

Abstract: It is the thesis of this article that the identification of extracapsular invasion of the metastatic lymph nodes can be taken as a useful prognostic sign in patients with resectable colorectal cancer.

Cited by 40 publications

References 9 publications

Prognostic value of extracapsular invasion and fibrotic focus in single lymph node metastasis of gastric cancer

Prognostic value of extracapsular invasion and fibrotic focus in single lymph node metastasis of gastric cancer

Relevance of extracapsular extension of pelvic lymph node metastasis in patients with bladder cancer treated in the contemporary era

Impact of treatment delay in patients with bladder cancer managed with partial cystectomy in Quebec: a population-based study

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