With rapid urbanization, traffic growth has accelerated in some cities in China. Due to strict urban construction land utilization policies, many high-rise apartment buildings have been constructed adjacent to expressways. To better understand the impact of urban traffic noise on the residents of high residential buildings adjacent to expressways and the differences in noise impacts on different floors, on-site noise monitoring and questionnaires for building residents have been conducted. The characteristics of traffic noise were analyzed based on the measured data, and factors, including time periods and building floors, were considered. According to the results of the questionnaire survey, 56.06% of the male respondents and 54.55% of the female respondents think that the impact of traffic noise on high-rise buildings is “high” or “very high”; 50.53% of the respondents who were in “good” or “very good” condition thought that the traffic noise has a “significant impact” or “very significant impact” on their sleep and daily life. In addition, 25% of respondents living on floors 4–10 and 62.5% of respondents living on floors 11–20 considered the traffic noise to have a “significant impact” or “very significant impact” on their sleep and daily life. The on-site noise monitoring results show that the noise levels (LAeq) outside the windows of the studied buildings remain significantly elevated, with daytime noise on working days ranging from 56 to 70 dB(A), and on weekends ranging from 50 to 65 dB(A). During the four time periods on weekdays from 7 a.m. to 9 a.m., 11 a.m. to 1 p.m., 5 p.m. to 7 p.m., and 10 p.m. to 12 a.m., the average LAeq levels on floors 11–20 are higher than those on floors 4–10 by 4.04 dB(A), 4.92 dB(A), 4.06 dB(A), and 2.67 dB(A), respectively. Similarly, during these time periods on weekends, the levels on floors 11–20 are higher than those on floors 4–10 by 4.96 dB(A), 6.32 dB(A), 5.28 dB(A), and 5.24 dB(A), respectively. This indicates that floors 4–10 of the building experience relatively lower noise levels, while floors 11–20 are subjected to comparatively higher levels of noise disturbance.