Identification of galangin as the bioactive compound from Alpinia calcarata (Haw.) Roscoe rhizomes to inhibit IRAK-1/ MAPK/ NF-κB p65 and JAK-1 signaling in LPS stimulated RAW 264.7 cells

Erusappan, Thamizharasi; Paramasivam, Sivasakthi; Ekambaram, Sanmuga Priya

doi:10.1016/j.jep.2022.114975

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…Besides, galangin reduced the RNA levels of COX‐2, IRAK‐1, and JAK‐1 M in a dose‐dependent manner. And galangin significantly down‐regulated the expression of JAK‐1, IRAK‐1, p38, ERK, and P65 (Erusappan et al, 2022). These results illustrated that galangin could exert anti‐RA effects by inhibiting IRAK‐1/p65/MAPK/JAK‐1, PI3K/AKT/mTOR, and JAK/STAT signaling pathways.…”

Section: Promising Role Of Galangin In Various Diseasesmentioning

confidence: 99%

Galangin: A food‐derived flavonoid with therapeutic potential against a wide spectrum of diseases

Wang,

Chen,

et al. 2023

Phytotherapy Research

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Galangin is an important flavonoid with natural activity, that is abundant in galangal and propolis. Currently, various biological activities of galangin have been disclosed, including anti‐inflammation, antibacterial effect, anti‐oxidative stress and aging, anti‐fibrosis, and antihypertensive effect. Based on the above bioactivities, more and more attention has been paid to the role of galangin in neurodegenerative diseases, rheumatoid arthritis, osteoarthritis, osteoporosis, skin diseases, and cancer. In this paper, the natural sources, pharmacokinetics, bioactivities, and therapeutic potential of galangin against various diseases were systematically reviewed by collecting and summarizing relevant literature. In addition, the molecular mechanism and new preparation of galangin in the treatment of related diseases are also discussed, to broaden the application prospect and provide reference for its clinical application. Furthermore, it should be noted that current toxicity and clinical studies of galangin are insufficient, and more evidence is needed to support its possibility as a functional food.

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Section: Promising Role Of Galangin In Various Diseasesmentioning

confidence: 99%

Galangin: A food‐derived flavonoid with therapeutic potential against a wide spectrum of diseases

Wang,

Chen,

et al. 2023

Phytotherapy Research

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“…4b-e and 5be). The p38 signaling pathway is involved in the regulation of CAM and proinflammatory cytokine expression during RA development (33,34). We, therefore, investigated whether Antcin K inhibits VCAM-1 expression and monocyte adhesion in RASFs via the p38 signaling pathway.…”

Section: Antcin K Inhibits Vcam-1 Synthesis By Suppressing Mek1/2-erk...mentioning

confidence: 99%

Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts

Achudhan¹,

Chang²,

Liu³

et al. 2022

Food & Nutrition Research

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Background: Antcin K, an extract of Antrodia cinnamomea (a medicinal mushroom endemic to Taiwan commonly used in Chinese medicine preparations), inhibits proinflammatory cytokine production and angiogenesis in human rheumatoid arthritis synovial fibroblasts (RASFs), major players in RA disease. Antcin K also inhibits disease activity in mice with collagen-induced arthritis (CIA). Up until now, the effects of Antcin K upon cell adhesion molecules (CAMs) were unknown. Methods: RA and healthy synovial tissue samples (n = 10 in each group) were retrieved from the Gene Expression Omnibus (GEO) database (accession code: GDS5401) to compare CAM and monocyte marker expressions. In addition, synovial tissue samples from six RA patients and six patients undergoing arthroscopy for trauma/joint derangement (healthy controls) were subjected to immunohistochemical (IHC) analysis. mRNA and protein expression levels were analyzed in RASFs using RT-qPCR (Reverse transcription-quantitative polymerase chain reaction) and Western blot. RASFs were incubated with Antcin K and examined for monocyte adherence by fluorescence microscopy. Ankle joint tissue specimens from a CIA mouse model and healthy controls were stained with hematoxylin and eosin (H&E) and Safranin-O/Fast Green to examine histological changes and evidence of bone loss. IHC analysis determined levels of vascular cell adhesion molecule 1 (VCAM-1) and CD11b in CIA ankle tissue and clinical synovial tissue. Results: Levels of VCAM-1 expression were higher in the GEO database specimens and the study’s clinical samples of RA synovial tissue compared with the healthy specimens. Antcin K dose-dependently inhibited VCAM-1 expression and monocyte adhesion in RASFs. Antcin K also significantly inhibited levels of VCAM-1 and monocyte CD11b expression in CIA tissue. These effects appeared to be mediated by MEK1/2-ERK, p38, and AP-1 signaling. Conclusions: Antcin K seems promising for the treatment of RA and deserves further investigations.

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“…f. Acanthaceae Roots Methanol NMR,TLC,CC [ 27 ] Galangin Alpinia officinarum Hance Zingiberaceae Rhizome Chloroform and methanol UV spectr,IR spectra,NMR [ 28 ] Helichrysum aureonitens Asteraceae Aerial part Acetone CC,HPLC,TLC, UV-VIS [ 29 ] Alpinia officinarum Hance Zingiberaceae Rhizome Methanol RP-HPLC,UV, IR spectra, MS, 1H-NMR, 13C-NMR [ 30 ] Alpinia calcarata (Haw.) Roscoe Zingiberaceae Rhizome Chloroform CC,TLC, NMR [ 31 ] Populus deltoides Bartram ex Marsh. Salicaceae Bud exudates GC-MS [ 32 ] Populus fremontii S. Watson Salicaceae Bud exudates GC-MS [ 32 ] Populus sargentii Salicaceae Bud exudates GC-MS [ 32 ] Populus wislizenii Salicaceae Bud exudates GC-MS [ …”

Section: Introductionmentioning

confidence: 99%

Flavonoids: A treasure house of prospective pharmacological potentials

Hasnat,

Shompa,

Islam

et al. 2024

Heliyon

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Identification of galangin as the bioactive compound from Alpinia calcarata (Haw.) Roscoe rhizomes to inhibit IRAK-1/ MAPK/ NF-κB p65 and JAK-1 signaling in LPS stimulated RAW 264.7 cells

Cited by 8 publications

References 36 publications

Galangin: A food‐derived flavonoid with therapeutic potential against a wide spectrum of diseases

Galangin: A food‐derived flavonoid with therapeutic potential against a wide spectrum of diseases

Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts

Flavonoids: A treasure house of prospective pharmacological potentials

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