Identification of genes associated with human-canine communication in canine evolution

Tonoike, Akiko; Otaki, Ken-ichi; Terauchi, Go; Ogawa, Misato; Maki, Kazuhiro; Sakata, Hikari; Miyasako, Fumina; Mogi, Kazutaka; Kikusui, Takefumi; Nagasawa, Miho

doi:10.1038/s41598-022-11130-x

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…Both loci contain at least one prominent neurodevelopmental gene ( SMAD4 and EPHA5 , respectively) and one neuropeptide receptor central to the Hypothalamic–Pituitary–Adrenal/-Gonadal axes (melanocortin/adrenocorticotropic hormone receptor MC2R , adrenal/HPA; and gonadotropin-releasing hormone receptor GNRHR , pituitary/HPG). A coding variant of MC2R common in ancient and herding dog breeds (~ 25% and ~ 8% allele frequencies, respectively), but absent or rare in other breeds including Labrador Retrievers, was shown to be associated with reduced gazing at experimenters in the “unsolvable test” 42 . Of our three mapped SNPs in the interval containing MC2R , the nearest to that variant position is 538,389 bp away (the others ~ 1 Mb or more).…”

Section: Discussionmentioning

confidence: 99%

Genome scanning of behavioral selection in a canine olfactory detection breeding cohort

Eyre

Zapata

Hare

et al. 2022

Sci Rep

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Research on working dogs is growing rapidly due to increasing global demand. Here we report genome scanning of the risk of puppies being eliminated for behavioral reasons prior to entering the training phase of the US Transportation Security Administration’s (TSA) canine olfactory detection breeding and training program through 2013. Elimination of dogs for behavioral rather than medical reasons was based on evaluations at three, six, nine and twelve months after birth. Throughout that period, the fostered dogs underwent standardized behavioral tests at TSA facilities, and, for a subset of tests, dogs were tested in four different environments. Using methods developed for family studies, we performed a case-control genome wide association study (GWAS) of elimination due to behavioral observation and testing results in a cohort of 528 Labrador Retrievers (2002–2013). We accounted for relatedness by including the pedigree as a covariate and maximized power by including individuals with phenotype, but not genotype, data (approximately half of this cohort). We determined genome wide significance based on Bonferroni adjustment of two quasi-likelihood score tests optimized for either small or nearly-fully penetrant effect sizes. Six loci were significant and five suggestive, with approximately equal numbers of loci for the two tests and frequencies of loci with single versus multiple mapped markers. Several loci implicate a single gene, including CHD2, NRG3 and PDE1A which have strong relevance to behavior in humans and other species. We briefly discuss how expanded studies of canine breeding programs could advance understanding of learning and performance in the mammalian life course. Although human interactions and other environmental conditions will remain critical, our findings suggest genomic breeding selection could help improve working dog populations.

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Section: Discussionmentioning

confidence: 99%

Genome scanning of behavioral selection in a canine olfactory detection breeding cohort

Eyre

Zapata

Hare

et al. 2022

Sci Rep

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“…During domestication, dogs were primarily selected for temperament, behaviour and cognitive abilities. However, the genetic basis of these abilities is not fully understood (Tonoike et al, 2022). Like many other mammals, they have a complex nervous system that allows them to perceive, process, and respond to a variety of stimuli.…”

Section: Introductionmentioning

confidence: 99%

Indicators of protein exchange in dogs with different types of higher nervous activity

Levchenko,

Korynevska,

Grigoriev

et al. 2023

Ukrainian journal of veterinary sciences

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The relevance of the study is due to the current lack of data on cortical mechanisms of protein metabolism regulation in dogs, which is important to consider when developing methods of corrective action on metabolism. The aim of the study was to determine the peculiarities of protein metabolism in dogs with different types of higher nervous activity, and to establish the relationship between the main characteristics of nervous processes and indicators of protein metabolism in the blood. The leading method in the study of this issue was a new method for determining the typological features of the nervous system in dogs, and the obtained scores of strength, balance, and mobility of nervous processes helped to identify the degree of their influence on protein metabolism. A significant effect of short-term nutritional deprivation on the content of certain indicators of protein metabolism in the blood of dogs, depending on their temperament, was established. Under the action of the stimulus during the day, a decrease in the level of albumin and changes in the ratio of globulins were observed in the blood of dogs, in particular, an increase in the relative content of α- and β-globulins and a decrease in γ-globulins. It was determined that the type of higher nervous activity has a significant effect on the content of total protein, albumin, globulins, β-globulins, γ-globulins and the value of the albumin-globulin ratio (F=3.02-14.6>FU=2.90; P<0.05-0.001) in the blood plasma of dogs. A direct relationship between the strength of nervous processes and the content of total protein and albumin, γ-globulins (r=0.62-0.73; P<0.01) and an inverse relationship between the content of αand β-globulins (r=-0.51-0.56; P<0.01) was found three days after the onset of short-term nutritional deprivation. The balance of nervous processes was inversely related to the content of β-globulins (r=-0.44; P<0.05). The fundamental knowledge gained is of practical value for the development of new, modern methods of metabolic correction taking into account the temperament of animals

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Human-directed sociability in the domestic dog: A Tinbergian approach

Boada,

Wirobski

2025

Neuroscience & Biobehavioral Reviews

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Identification of genes associated with human-canine communication in canine evolution

Cited by 5 publications

References 40 publications

Genome scanning of behavioral selection in a canine olfactory detection breeding cohort

Genome scanning of behavioral selection in a canine olfactory detection breeding cohort

Indicators of protein exchange in dogs with different types of higher nervous activity

Human-directed sociability in the domestic dog: A Tinbergian approach

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