2021
DOI: 10.1016/j.bbrep.2021.101053
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Identification of genes modulated by interferon gamma in breast cancer cells

Abstract: Interferon gamma (IFNγ) plays a context-dependent dual tumor-suppressor and pro-tumorigenic roles in cancer. IFNγ induces morphological changes in breast cancer (BC) cells with or without estrogen receptor alpha (ERα) expression. However, IFNγ-regulated genes in BC cells remain unexplored. Here, we performed a cDNA microarray analysis of MCF-7 (ERα+) and MDA-MB-231 (HER2-/PR-/ERα-) cells with and without IFNγ treatment. We identified specific IFNγ−modulated genes in each cell type, and a small group of genes r… Show more

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Cited by 12 publications
(7 citation statements)
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“…For example, interferon gamma response is only reported in the cross-regional analysis for the second subject but not the first, while angiogenesis and myogenesis are mostly observed in the first patient. Interferon gamma plays context-dependent dual tumor-suppressor and pro-tumorigenic roles in breast cancer ( Tecalco-Cruz et al 2021 ). The up- and down-regulation of interferon gamma response may be associated with intratumor heterogeneity in the first patient.…”
Section: Resultsmentioning
confidence: 99%
“…For example, interferon gamma response is only reported in the cross-regional analysis for the second subject but not the first, while angiogenesis and myogenesis are mostly observed in the first patient. Interferon gamma plays context-dependent dual tumor-suppressor and pro-tumorigenic roles in breast cancer ( Tecalco-Cruz et al 2021 ). The up- and down-regulation of interferon gamma response may be associated with intratumor heterogeneity in the first patient.…”
Section: Resultsmentioning
confidence: 99%
“…Even if IFN-α signaling pathway contributes to apoptosis and cellular senescence, in contrast, it also could play a role in increased migration and drug resistance, depending on the interferon-stimulated transcribed genes [ 157 ]. Interferon gamma also plays a dual tumor-suppressor and protumorigenic roles in cancer [ 158 ]. In inflammatory breast cancer (IBC) cells, the increased levels of IFN-α has been reported as protumorigenic factors involved in IBC progression [ 157 ].…”
Section: Resultsmentioning
confidence: 99%
“…The microarray service of the Microarray Unit of the Cellular Physiology Institute of UNAM was used. 15 …”
Section: Methodsmentioning
confidence: 99%