2014
DOI: 10.1371/journal.pone.0098552
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Identification of Glyceraldehyde 3-Phosphate Dehydrogenase Sequence and Expression Profiles in Tree Shrew (Tupaia belangeri)

Abstract: The tree shrews (Tupaia belangeri) diverged from the primate order (Primates) and are classified as Scandentia, a separate taxonomic group of mammals. The tree shrew has been suggested to use an animal model to study human disease but the genomic sequences of tree shrew is largely unidentified. Here we identified the full-length cDNA sequence of a housekeeping gene, Glyceraldehyde 3-phosphate Dehydrogenase (GAPDH), in tree shrew. We further constructed a phylogenetic family tree base on GAPDH molecules of vari… Show more

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Cited by 6 publications
(3 citation statements)
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“…PspA binds to both huGAPDH and mouse GAPDH; these have 94% aa sequence identity ( Zheng et al, 2014 ). GAPDH consists of two highly conserved domains: an NAD + binding domain (aa 1–150) and the catalytic glyceraldehyde-3-phosphate domain (aa 151–335).…”
Section: Discussionmentioning
confidence: 99%
“…PspA binds to both huGAPDH and mouse GAPDH; these have 94% aa sequence identity ( Zheng et al, 2014 ). GAPDH consists of two highly conserved domains: an NAD + binding domain (aa 1–150) and the catalytic glyceraldehyde-3-phosphate domain (aa 151–335).…”
Section: Discussionmentioning
confidence: 99%
“…It was found that the amino acid composition of GAPDH protein found similar in all species of domestic animal (Zheng et al, 2014). The result of physiochemical properties of GAPDH enzyme of Cattle, W. buffalo sheep, goat, pig and dog did not show much variation in amino acid composition, extinction coefficient, half life time.…”
Section: Physiochemical Analysismentioning
confidence: 83%
“…As a new animal model, the genome of the tree shrew has just been revealed [ 18 ]; thus, related immunology research tools are urgently needed. Recently, the literature has described some tree shrew cytokines and molecules, such as CXCR4, IL-7, IL-2 and GAPDH [ 23 26 ]; however, the cross-reactivity phenomenon was not clearly revealed until now. Here, our study on the homology and cross-reactivity of tsIL-21 will be an important supplement to immunology research on the tree shrew.…”
Section: Discussionmentioning
confidence: 99%