Identification of HMG-box family establishes the significance of SOX6 in the malignant progression of glioblastoma

Jiang, Lan; Yang, Hui; Chen, Tianbing; Zhu, Xiaolong; Ye, Jingjing; Lv, Kun

doi:10.18632/aging.103127

Cited by 10 publications

(11 citation statements)

References 65 publications

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“…The miRNAs found altered in GBM have been widely reported, hsa‐miR‐21 was overexpressed in the development and progression of GBM 52 . Our previous study has established ceRNA network and identified miRNA, lncRNA and TF were glioma‐related molecules in GBM 6 . In current study, hsa‐miR‐21‐5p was involved in the regulation of CDK4 and MYC, which known to be detected in the GBM development.…”

Section: Discussionsupporting

confidence: 49%

“…The blood biomarkers (LRG1 (Leucine Rich Alpha‐2‐Glycoprotein 1), CRP (C‐Reactive Protein) and C9 (Complement C9)) revealed significant positive correlations with tumour size 14 . Our previous study also reported that HMG‐box family and related ceRNA (competing endogenous RNA) established the significance of SOX6 (SRY‐Box Transcription Factor 6) in the malignant progression of glioblastoma 6 …”

Section: Introductionmentioning

confidence: 68%

“…Biomarkers could combine with different diseases and display a high value which lead to the development of a robust, effective take on GBM therapy 5 . Numerous recent studies have discovered the biomarkers in GBM from molecular biology to proteomics, such as circulating tumour DNA (ctDNA), DNA, microRNA (miRNA), lncRNA (long non‐coding RNA) and protein 6‐8 . ctDNAs in cerebrospinal fluid better reflected the sequential change of those tumour drivers than in plasma, which served as biomarkers to improve patients’ outcomes 9 .…”

Section: Introductionmentioning

confidence: 99%

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Gene regulation network analysis reveals core genes associated with survival in glioblastoma multiforme

Jiang

Zhong

Chen

et al. 2020

J Cellular Molecular Medi

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Glioblastoma multiforme (GBM) is a very serious mortality of central nervous system cancer. The microarray data from http://GSE2223, http://GSE4058, http://GSE4290, http://GSE13276, http://GSE68848 and http://GSE70231 (389 GBM tumour and 67 normal tissues) and the RNA‐seq data from TCGA‐GBM dataset (169 GBM and five normal samples) were chosen to find differentially expressed genes (DEGs). RRA (Robust rank aggregation) method was used to integrate seven datasets and calculate 133 DEGs (82 up‐regulated and 51 down‐regulated genes). Subsequently, through the PPI (protein‐protein interaction) network and MCODE/ cytoHubba methods, we finally filtered out ten hub genes, including FOXM1, CDK4, TOP2A, RRM2, MYBL2, MCM2, CDC20, CCNB2, MYC and EZH2, from the whole network. Functional enrichment analyses of DEGs were conducted to show that these hub genes were enriched in various cancer‐related functions and pathways significantly. We also selected CCNB2, CDC20 and MYBL2 as core biomarkers, and further validated them in CGGA, HPA and CCLE database, suggesting that these three core hub genes may be involved in the origin of GBM. All these potential biomarkers for GBM might be helpful for illustrating the important role of molecular mechanisms of tumorigenesis in the diagnosis, prognosis and targeted therapy of GBM cancer.

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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Gene regulation network analysis reveals core genes associated with survival in glioblastoma multiforme

Jiang

Zhong

Chen

et al. 2020

J Cellular Molecular Medi

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“…The discovery of potential biomarkers is important to improve diagnosis, prognosis, and targeted therapy of GBM. Recently, we detected the HMG-box family establishing the significance of SOX6 in the malignant progression of GBM (Jiang et al, 2020a), and found three core genes associated with survival in GBM (Jiang et al, 2020b). Besides, another study revealed that expression of 77 known genes can serve as biomarker in pan-cancer (Ji and Cui, 2020).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma

et al. 2020

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Glioblastoma (GBM) has long been a major clinical research challenge to scientists. The pivotal role of the mitochondria related gene family in the promotion of GBM tumorigenesis is not clear. We detected that microtubular tubulin beta 6 class V (TUBB6) was one of 33 differentially expressed mitochondrial-focused genes (DEMFGs) in GBM, and considered that TUBB6 is a potential therapeutic target in GBM. TUBB6 was vital for GBM and marked as the key prognostic gene in primary GBM. Mutations of TUBB6 in GBM were rare. Only four TUBB6 co-expressed hub genes (ANXA2, S100A11, FLNA, and MSN) exhibited poorer overall survival rates in higher expression groups (p-value < 0.05). We have confirmed the up-regulation of TUBB6 and its partners, ANXA2 and S100A11 in GBM and validated their importance as prognostic factors in primary GBM. TUBB6 was significantly correlated with stromal score in GBM samples (p-value = 6.99E-04). This study aimed to assess the importance of novel hub genes by analyzing the expression, potential function and prognostic impact of TUBB6 in human primary GBM cancer.

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“…These contradictory data probably arose as a consequence of GBM heterogeneity. Furthermore, it was shown that low SOX6 expression in patients with GBM contributes to a better survival rate than that in patients who display high SOX6 expression[ 116 ]. Functional analyses have shown that SOX7 acts as a tumor suppressor.…”

Section: Role Of Sox Genes In Gbm and Correlations With Prognosis And Survival Of Patientsmentioning

confidence: 99%

SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation

Stevanović

Kovacevic-Grujicic

Mojsin

et al. 2021

WJSC

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Glioblastoma (GBM) is the most common, most aggressive and deadliest brain tumor. Recently, remarkable progress has been made towards understanding the cellular and molecular biology of gliomas. GBM tumor initiation, progression and relapse as well as resistance to treatments are associated with glioma stem cells (GSCs). GSCs exhibit a high proliferation rate and self-renewal capacity and the ability to differentiate into diverse cell types, generating a range of distinct cell types within the tumor, leading to cellular heterogeneity. GBM tumors may contain different subsets of GSCs, and some of them may adopt a quiescent state that protects them against chemotherapy and radiotherapy. GSCs enriched in recurrent gliomas acquire more aggressive and therapy-resistant properties, making them more malignant, able to rapidly spread. The impact of SOX transcription factors (TFs) on brain tumors has been extensively studied in the last decade. Almost all SOX genes are expressed in GBM, and their expression levels are associated with patient prognosis and survival. Numerous SOX TFs are involved in the maintenance of the stemness of GSCs or play a role in the initiation of GSC differentiation. The fine-tuning of SOX gene expression levels controls the balance between cell stemness and differentiation. Therefore, innovative therapies targeting SOX TFs are emerging as promising tools for combatting GBM. Combatting GBM has been a demanding and challenging goal for decades. The current therapeutic strategies have not yet provided a cure for GBM and have only resulted in a slight improvement in patient survival. Novel approaches will require the fine adjustment of multimodal therapeutic strategies that simultaneously target numerous hallmarks of cancer cells to win the battle against GBM.

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Identification of HMG-box family establishes the significance of SOX6 in the malignant progression of glioblastoma

Cited by 10 publications

References 65 publications

Gene regulation network analysis reveals core genes associated with survival in glioblastoma multiforme

Gene regulation network analysis reveals core genes associated with survival in glioblastoma multiforme

Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma

SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation

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