Identification of human immunodeficiency virus hybridizing sequences in the peripheral blood of a patient with systemic lupus erythematosus

Blick, Mark; Bresser, Joel; Lepe-Zuniga, Jose L.; Goodacre, Angela; Luethke, David; Holder, William Robert; Duvic, Madeleine

doi:10.1016/0190-9622(90)70266-k

Cited by 10 publications

(2 citation statements)

References 27 publications

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“…Tala1 and coworkers (19) recently showed that anti-Sm RNP antibodies may cross-react with retroviral (HIV-1) p24 Gag protein. Evidence of retroviral genomic material in individual patients with autoimmune diseases has also been described, for example, the demonstration of HIV-1-related messenger RNA sequences, by in situ hybridization, in peripheral blood cells of a patient with systemic lupus erythematosus (SLE) (20), and the development of A-type retroviral particles in lymphoid cell cocultures of salivary gland homogenate derived from a patient with Sjogren's syndrome (21). Attempts to isolate a replicating retrovirus from the peripheral blood cells of SLE patients, however, have been unsuccessful (22).…”

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confidence: 99%

Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Ranki

Kurki

Riepponen

et al. 1992

Arthritis & Rheumatism

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Objective. To study the relationship between antibodies that recognize human retroviral proteins and the presence of clinical features and ribonucleoprotein antibodies in patients with autoimmune connective tissue diseases (CTDs).Methods. Antibodies against native human immunodeficiency virus type 1 (HIV-1) and human T cell leukemiahymphoma virus type I, recombinant HIV-1 Nef protein, and ribonucleoprotein antigens were determined by immunoblot of sera from 65 prospectively studied patients with definite ur suspected CTDs of autoimmune type.Results. Antibodies to retroviral proteins (ARP), most frequently to HIV Gag proteins p55 and p24, were found in 64% of 22 patients with systemic lupus erythematosus (SLE), in 63% of 8 patients with discoid LE From the

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confidence: 99%

Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Ranki

Kurki

Riepponen

et al. 1992

Arthritis & Rheumatism

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“…Some investigators reported antibodies to HIV-1 gag protein p24, or cross-reactive with HTLV-1 in patients with SLE. HIV-1-related mRNA was also detected in SLE peripheral blood by in situ hybridization [14]. However, direct evidence of viral infection in SLE has rarely been reported [15].…”

Section: Introductionmentioning

confidence: 97%

Syncytial cell formation in vivo by type C retroviral particles in the systemic lupus erythematosus (SLE) lung

Tamura

Sekigawa

Hashimoto

et al. 1997

Clinical and Experimental Immunology

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SUMMARYSignificant numbers of syncytial cells were observed in the bronchoalveolar lavage fluid (BALF) of a 42-year-old patient who had SLE with interstitial pneumonia. Electron microscopic study of the BALF cells and positive reverse transcriptase activity in the supernatant of the cultured cells revealed unknown retroviral particles in the BALF cells. No antibodies to known human retroviruses or proviral sequences were detected. Type C retroviral particles and positive reverse transcriptase activity were also observed in co-cultured U937 cells. To evaluate the pathogenic role of unknown type C retroviral particles, screening for antibodies to this retroviral particle was performed by immunofluorescence in 26 patients with idiopathic pulmonary fibrosis, 17 patients with SLE, 22 patients with lung cancer, and 58 healthy volunteers. Serum antibody to this putative type C retrovirus was detected in 24% of SLE patients, 27% of idiopathic pulmonary fibrosis patients, none of the lung cancer patients and 2% of healthy volunteers. Although no direct evidence of this virus as the pathogen for SLE could be demonstrated, a possible role in the development of SLE and interstitial pneumonia might be suggested.

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New evidence for involvement of retroviruses in sjögren's syndrome and other autoimmune diseases

Garry¹

1994

Arthritis & Rheumatism

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Identification of human immunodeficiency virus hybridizing sequences in the peripheral blood of a patient with systemic lupus erythematosus

Cited by 10 publications

References 27 publications

Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Syncytial cell formation in vivo by type C retroviral particles in the systemic lupus erythematosus (SLE) lung

New evidence for involvement of retroviruses in sjögren's syndrome and other autoimmune diseases

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