Identification of human papillomavirus in pterygium

Hamed-Azzam, Shirin; Edison, Natalia; Briscoe, Daniel; Mukari, Abed; Elmalah, Irit

doi:10.1111/aos.12729

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…HPV has been extensively studied as a possible pathogenetic co-factor; however controversy exists between different studies (Table I). In their studies, McDonnell et al (20), Dushku et al (22), Chen et al (26), Schellini et al (28), Kuo et al (29), Otlu et al (32), Guthoff et al (34) and Hamed-Azzam et al (38) did not detect HPV in pterygia, while Sjo et al (13), Takamura et al (30) and Hsaio et al (36) noted a very low prevalence of the virus ranging from 3-4,8%.…”

Section: Hpv Detection In Ophthalmic Pterygiummentioning

confidence: 99%

Human papillomavirus infection and ocular surface disease (Review)

et al. 2019

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Human papillomavirus (HPV) infection has been implicated as a primary cause of lesions in the anogenital region, skin, oropharynx and respiratory tract. Additionally, the role of HPV in the pathogenesis of ocular surface disease has also been extensively studied. Conjunctival papilloma development has been strongly associated with the HPV infection of certain subtypes. On the other hand, the role of HPV in conjunctival pterygium, conjunctival intraepithelial neoplasia (CIN) and ocular surface squamous neoplasia (OSSN) remains controversial. Genetic predisposition and environmental factor is important in HPV hosts as regards the pathogenesis of ocular surface disease. Several studies have indicate a synergic role of HPV with ultraviolet radiation in pterygium establishment. A higher recurrence risk rate and more aggressive disease of ophthalmic pterygium is observed in cases of HPV infection. The purpose of this review was to provide a systematic review of the literature and to assist in a better understanding of the role of HPV in ocular surface disease.

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Section: Hpv Detection In Ophthalmic Pterygiummentioning

confidence: 99%

Human papillomavirus infection and ocular surface disease (Review)

et al. 2019

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“…A pterygium is a fibrovascular and wing-shaped neoplasm that can invade the cornea and cover the pupil area [1]. Pterygia are common causes of induced astigmatism, ocular movement restriction, and visual impairment [2]. There are many treatments for pterygium.…”

Section: Introductionmentioning

confidence: 99%

Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors

Guo

Xiao

Cui

et al. 2019

Journal of Ophthalmology

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A pterygium is generally believed to be a chronic inflammatory lesion caused by external stimuli that develops from the conjunctiva and grows onto the cornea. Simple bare sclera excision is the most commonly used method to treat pterygium. However, the high postoperative recurrence rate of pterygium remains a persistent challenge. Mitomycin C (MMC) is an antineoplastic antibiotic that inhibits DNA, RNA, and protein synthesis. In recent years, although MMC has proven useful for the treatment of pterygium, its application has been controversial because of its clear toxicity and the possibility of ocular complications. In the current study, we prospectively recruited patients to receive or not receive a local injection of MMC (0.4 mg/ml). Follow-up was conducted with the patients to determine the postoperative recurrence rate of pterygium and/or to observe any ocular complications. The remarkable results demonstrated that MMC can decrease the postoperative recurrence rate of pterygium without leading to serious eye complications. Further results indicated that MMC can inhibit the activation of the NLRP3 inflammatory signalling pathway and thus downregulate the expression of downstream molecules, including IL-18 and IL-1β. MMC also reduced the expression of inflammatory factors TGF-β1, VEGF, and IL-6. In addition to influencing these factors, MMC suppressed neovascularization and the proliferation of corneal fibroblasts to effectively reduce the recurrence rate of pterygium. Taken together, our results provide a theoretical basis for the development of prevention and treatment strategies for pterygium and suggest that MMC is highly effective as an adjunctive treatment after excision of primary pterygia.

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“…A meta-analysis reported an overall prevalence rate of 18.6% for HPV infection in pterygium. 38 Such differences in these statistics can be due to diverse study tools detection of viruses, various lifestyles, and diverse geographic area. Types 16, 18 HPV, as high-risk viruses for the development of cancer, have been frequently isolated from pterygium-associated genotypes.…”

Section: Diagnosis Of Hpv and Other Viral Etiologies In Pterygiummentioning

confidence: 99%

The Role of Viruses in the Development of Ocular Surface Squamous Neoplasia and Pterygium

2023

JPTCP

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High prevalence of infections with human papillomavirus (HPV) and human immunodeficiency virus (HIV) is reportedly associated with an increased frequency of ocular surface squamous neoplasia (OSSN).The present review article aimed to evaluate the relationship between viruses such as HIV/HPV with OSSN and HPV with other possible related viruses with a pterygium. HIV infection increases the frequency and severity of OSSN, although the documented report on the involvement of HPV is inconclusive.The research findings evaluating both mucosal and cutaneous subtypes of HPV infection suggested an association only between the cutaneous subtype and the increased risk of OSSN. Despite uncertainties on the function of oncogenic viruses in pterygium development, the present literature found a clear disparity.The available data elucidate the potential of these viruses in the pathogenesis of pterygium, at least in a certain group of patients.

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Identification of human papillomavirus in pterygium

Cited by 7 publications

References 28 publications

Human papillomavirus infection and ocular surface disease (Review)

Human papillomavirus infection and ocular surface disease (Review)

Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors

The Role of Viruses in the Development of Ocular Surface Squamous Neoplasia and Pterygium

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